CEBPB

CEBPB
여기서 "CRP2"가 리다이렉트 됩니다.공항에 대해서는 Reston/R을 참조하십시오.핍스톤 공항의 M.
CEBPB
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사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스CEBPB, C/EBP-β, IL6DBP, NF-IL6, TCF5, CCAAT/증강제 결합단백질 베타, CCAAT 결합단백질 베타
외부 IDOMIM: 189965 MGI: 88373 HomoloGene: 3807 GenCard: CEBPB
맞춤법
종.인간마우스
엔트레즈

1051

12608

앙상블

ENSG00000172216

ENSMUSG000056501

유니프로트

P17676

P28033

RefSeq(mRNA)

NM_005194
NM_001285878
NM_001285879

NM_00128738
NM_00128739
NM_009883

RefSeq(단백질)

NP_001272807
NP_001272808
NP_005185

NP_001274667
NP_001274668
NP_034013

장소(UCSC)Chr 20: 50.19 ~50.19 MbChr 2: 167.53 ~167.53 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

CCAAT/인핸서 결합 단백질 베타는 CEBPB [5][6]유전자에 의해 사람에게서 코드되는 단백질이다.

기능.

이 인트론리스 유전자에 의해 암호화된 단백질은 특정 DNA 조절 영역에 호모디머로 결합할 수 있는 bZIP 전사 인자입니다.또한 CEBP-alpha, CEBP-delta 및 CEBP-gamma와 관련된 단백질과 헤테로디미터를 형성할 수 있다.암호화 단백질은 면역 및 염증 반응에 관여하는 유전자의 조절에 중요하며 IL-6 유전자의 IL-1 반응 요소뿐만 아니라 여러 급성 상 및 사이토카인 유전자의 조절 영역에도 결합하는 것으로 나타났다.또한 상기 부호화 단백질은 프로모터와 상류 요소를 결합시켜 콜라겐형 I [7]유전자의 발현을 자극할 수 있다.

CEBP-beta는 중요한 면역 세포 하위 유형인 정상적인 대식세포 기능에 중요하다. CEBP-beta를 발현할 수 없는 생쥐는 분화할 수 없는(전문화) 대식세포를 가지고 있으며, 따라서 대식세포 매개 근육 [8]수복을 포함한 모든 생물학적 기능을 수행할 수 없다.관찰 연구는 혈액 백혈구에서 CEBP-베타의 발현이 근육 기능 유지에서 면역 시스템, 특히 대식세포의 중요성을 강조하면서 인간의 근육 [9]강도와 긍정적으로 연관되어 있음을 보여주었다.

CEBPB 유전자의 기능은 독립적 [10]검증에 기초한 siRNA 녹다운에 의해 효과적으로 검사할 수 있다.

표적 유전자

CEBPB는 여러 표적 유전자의 발현을 증가시킬 수 있다.이들 중 일부는 프레프로타키닌-1 유전자와 같은 신경계에서 특이적 역할을 하며, 물질 P와 신경키닌[11] A 및 중요한 신경전달물질인 아세틸콜린의 [12]생합성을 담당하는 콜린아세틸전달효소를 발생시킨다.다른 표적에는 [13]IL-6,[14] IL-4,[15] IL-5, [16]TNF-alpha와 같은 사이토카인을 코드하는 유전자가 포함된다.세포에 다제내성을 부여하는 운반단백질을 코드하는 유전자도 CEBPB에 의해 활성화되는 것으로 밝혀졌다.이러한 유전자는 ABCC2와 ABCB1을 [18]포함한다[17].

상호 작용

CEBPB는 다음과 상호작용하는 것으로 나타났습니다.

「 」를 참조해 주세요.

레퍼런스

  1. ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000172216 - 앙상블, 2017년 5월
  2. ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000056501 - 앙상블, 2017년 5월
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (Jul 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.
  6. ^ Cao Z, Umek RM, McKnight SL (Oct 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev. 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554.
  7. ^ "Entrez Gene: CEBPB CCAAT/enhancer binding protein (C/EBP), beta".
  8. ^ Ruffell D, Mourkioti F, Gambardella A, Kirstetter P, Lopez RG, Rosenthal N, Nerlov C (2009). "A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair". Proc. Natl. Acad. Sci. U.S.A. 106 (41): 17475–80. Bibcode:2009PNAS..10617475R. doi:10.1073/pnas.0908641106. PMC 2762675. PMID 19805133.
  9. ^ Harries LW, Pilling LC, Hernandez LD, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D (2012). "CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength". Aging Cell. 11 (2): 262–8. doi:10.1111/j.1474-9726.2011.00782.x. PMC 3486692. PMID 22152057.
  10. ^ Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs (2016-01-01). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy: Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. ISSN 2162-2531. PMC 5056990. PMID 27673562.
  11. ^ Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR (September 2006). "C/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones". J. Neurochem. 98 (5): 1390–9. doi:10.1111/j.1471-4159.2006.03957.x. PMID 16771829. S2CID 36225447.
  12. ^ Robert I, Sutter A, Quirin-Stricker C (October 2002). "Synergistic activation of the human choline acetyltransferase gene by c-Myb and C/EBPbeta". Brain Res. Mol. Brain Res. 106 (1–2): 124–35. doi:10.1016/S0169-328X(02)00419-9. PMID 12393272.
  13. ^ Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, Kishimoto T (January 1992). "Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6". Blood. 79 (2): 460–6. doi:10.1182/blood.V79.2.460.460. PMID 1730090.
  14. ^ Davydov IV, Krammer PH, Li-Weber M (December 1995). "Nuclear factor-IL6 activates the human IL-4 promoter in T cells". J. Immunol. 155 (11): 5273–9. PMID 7594540.
  15. ^ van Dijk TB, Baltus B, Raaijmakers JA, Lammers JW, Koenderman L, de Groot RP (September 1999). "A composite C/EBP binding site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor beta c gene". J. Immunol. 163 (5): 2674–80. PMID 10453008.
  16. ^ Greenwel P, Tanaka S, Penkov D, Zhang W, Olive M, Moll J, Vinson C, Di Liberto M, Ramirez F (February 2000). "Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins". Mol. Cell. Biol. 20 (3): 912–8. doi:10.1128/MCB.20.3.912-918.2000. PMC 85208. PMID 10629048.
  17. ^ Tanaka T, Uchiumi T, Hinoshita E, Inokuchi A, Toh S, Wada M, Takano H, Kohno K, Kuwano M (December 1999). "The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells". Hepatology. 30 (6): 1507–12. doi:10.1002/hep.510300617. PMID 10573531. S2CID 22514353.
  18. ^ Chen GK, Sale S, Tan T, Ermoian RP, Sikic BI (April 2004). "CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells". Mol. Pharmacol. 65 (4): 906–16. doi:10.1124/mol.65.4.906. PMID 15044620.
  19. ^ Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB (2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Mol. Cell. Biol. 23 (12): 4066–82. doi:10.1128/mcb.23.12.4066-4082.2003. PMC 156132. PMID 12773552.
  20. ^ Mo X, Kowenz-Leutz E, Xu H, Leutz A (January 2004). "Ras induces mediator complex exchange on C/EBP beta". Mol. Cell. 13 (2): 241–50. doi:10.1016/s1097-2765(03)00521-5. PMID 14759369.
  21. ^ Hattori T, Ohoka N, Hayashi H, Onozaki K (April 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. 541 (1–3): 33–9. doi:10.1016/s0014-5793(03)00283-7. PMID 12706815. S2CID 43792576.
  22. ^ Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ (June 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. 271 (24): 14285–9. doi:10.1074/jbc.271.24.14285. PMID 8662954.
  23. ^ Mink S, Haenig B, Klempnauer KH (November 1997). "Interaction and functional collaboration of p300 and C/EBPbeta". Mol. Cell. Biol. 17 (11): 6609–17. doi:10.1128/mcb.17.11.6609. PMC 232514. PMID 9343424.
  24. ^ a b Boruk M, Savory JG, Haché RJ (November 1998). "AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor". Mol. Endocrinol. 12 (11): 1749–63. doi:10.1210/mend.12.11.0191. PMID 9817600.
  25. ^ Stein B, Yang MX (September 1995). "Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta". Mol. Cell. Biol. 15 (9): 4971–9. doi:10.1128/mcb.15.9.4971. PMC 230744. PMID 7651415.
  26. ^ a b Foti D, Iuliano R, Chiefari E, Brunetti A (2003). "A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription". Mol. Cell. Biol. 23 (8): 2720–32. doi:10.1128/mcb.23.8.2720-2732.2003. PMC 152545. PMID 12665574.
  27. ^ Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK (April 2002). "Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6". J. Biol. Chem. 277 (14): 11802–10. doi:10.1074/jbc.M109296200. PMID 11801594.
  28. ^ Miau LH, Chang CJ, Shen BJ, Tsai WH, Lee SC (April 1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. 273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. PMID 9553145.
  29. ^ Weber M, Sydlik C, Quirling M, Nothdurfter C, Zwergal A, Heiss P, Bell S, Neumeier D, Ziegler-Heitbrock HW, Brand K (June 2003). "Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta". J. Biol. Chem. 278 (26): 23586–93. doi:10.1074/jbc.M211646200. PMID 12707271.
  30. ^ Xia C, Cheshire JK, Patel H, Woo P (December 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". Int. J. Biochem. Cell Biol. 29 (12): 1525–39. doi:10.1016/s1357-2725(97)00083-6. PMID 9570146.
  31. ^ Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta". J. Biol. Chem. 274 (20): 14224–8. doi:10.1074/jbc.274.20.14224. PMID 10318842.
  32. ^ Sealy L, Malone D, Pawlak M (March 1997). "Regulation of the cfos serum response element by C/EBPbeta". Mol. Cell. Biol. 17 (3): 1744–55. doi:10.1128/mcb.17.3.1744. PMC 231899. PMID 9032301.
  33. ^ Kowenz-Leutz E, Leutz A (November 1999). "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes". Mol. Cell. 4 (5): 735–43. doi:10.1016/s1097-2765(00)80384-6. PMID 10619021.
  34. ^ Liu YW, Tseng HP, Chen LC, Chen BK, Chang WC (July 2003). "Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages". J. Immunol. 171 (2): 821–8. doi:10.4049/jimmunol.171.2.821. PMID 12847250.
  35. ^ Rooney JW, Calame KL (2001). "TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937". Genes Dev. 15 (22): 3023–38. doi:10.1101/gad.937201. PMC 312827. PMID 11711437.
  36. ^ Chang CJ, Chen YL, Lee SC (October 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression". Mol. Cell. Biol. 18 (10): 5880–7. doi:10.1128/mcb.18.10.5880. PMC 109174. PMID 9742105.
  37. ^ Zhang F, Lin M, Abidi P, Thiel G, Liu J (November 2003). "Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene". J. Biol. Chem. 278 (45): 44246–54. doi:10.1074/jbc.M305564200. PMID 12947119.

외부 링크

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.