ZEB1

ZEB1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2E19
식별자
에일리어스	ZEB1, 아연핑거E박스결합호메오박스1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
외부 ID	OMIM : 189909 MGI : 1344313 HomoloGene : 31779 GenCard : ZEB1
유전자 위치(인간)
크르.	10번 염색체(인간)
끝.	31,529,814 bp
유전자 위치(마우스)
크르.	18번 염색체(쥐)
끝.	5,775,467 bp
RNA발현패턴
	상단 표시 위치:
	아킬레스건; ; 시신경; ; 내피 세포; ; 상완 이두근; ; 자궁내막간질세포; ; 상완 삼두근; ; 신경절 융기; ; 우심실; ; 심막; ; 활액관절;
	상단 표시 위치:
	내경동맥; ; 흑색 실체; ; 운동 뉴런; ; 외경동맥; ; 반잠금 밸브; ; 경동맥체; ; 상행 대동맥; ; 쇄골상핵; ; 발목; ; 중앙 융기;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; 전사 코어프레서 활성; 전사공활성화제활성; 아연 이온 결합; 전사 인자 결합; 크로마틴 결합; 금속 이온 결합; 단백질 결합; 핵산 결합; DNA결합전사억제제활성, RNA중합효소II 특이적; DNA결합전사인자활성; E-box 바인딩; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	전사조절복합체; 핵; 핵소체; 세포;
생물학적 과정	패턴 특정 프로세스; 배아 골격계 형태 형성; 평활근 세포 분화 조절; 동물 기관의 발달; 세포 분화; 반고리관 형태 형성; 전사조절, DNA템플릿화; RNA중합효소II에 의한 전사조절; 전사, DNA 템플릿; 신경계의 발달; 형질전환인자β수용체신호경로조절; 흉선의 T세포 분화 조절; 중추 신경계의 발달; 연골 발달; 간엽세포증식조절; 배아 카메라형 안구 형태 형성; 달팽이관 형태 형성; 면역 반응; 배아 형태 형성; 아미노산 자극에 대한 세포 반응; 세포군 증식; 상피세포분화음성조절; RNA중합효소II에 의한 전사의 양성 조절; 세포군 증식의 음성 조절; 전사 음성 조절, DNA 템플릿; 뉴런 분화의 양성 조절; RNA중합효소II에 의한 전사 음성 조절; 내피세포분화음성조절; 사이토카인결합신호경로;
	출처:아미고 / QuickGO
맞춤법
	6935
	21417
	ENSG00000148516
	ENSMUSG000024238
	P37275
	Q64318
NM_001128128; NM_001174093; NM_001174094; NM_001174095; NM_001174096;
	NM_030751; NM_001323638; NM_001323641; NM_001323642; NM_001323643; NM_001323644; NM_001323645; NM_001323646; NM_001323647; NM_001323648; NM_001323649; NM_001323650; NM_001323651; NM_001323652; NM_001323653; NM_001323654; NM_001323655; NM_001323656; NM_001323657; NM_001323658; NM_001323659; NM_001323660; NM_001323661; NM_001323662; NM_001323663; NM_001323664; NM_001323665; NM_001323666; NM_001323671; NM_001323672; NM_001323673; NM_001323674; NM_001323675; NM_001323676; NM_001323677; NM_001323678
	NM_011546; NM_001360981; NM_001360982
NP_001121600; NP_001167564; NP_001167565; NP_001167566; NP_001167567;
	NP_001310567; NP_001310570; NP_001310571; NP_001310572; NP_001310573; NP_001310574; NP_001310575; NP_001310576; NP_001310577; NP_001310578; NP_001310579; NP_001310580; NP_001310581; NP_001310582; NP_001310583; NP_001310584; NP_001310585; NP_001310586; NP_001310587; NP_001310588; NP_001310589; NP_001310590; NP_001310591; NP_001310592; NP_001310593; NP_001310594; NP_001310595; NP_001310600; NP_001310601; NP_001310602; NP_001310603; NP_001310604; NP_001310605; NP_001310606; NP_001310607; NP_110378
	NP_035676; NP_001347910; NP_001347911
	위키데이터
인간 보기/편집	마우스 표시/편집

아연 핑거 E박스 결합 호메오박스 1은 ZEB1 ^[5]^[6]^[7]유전자에 의해 인체 내에서 부호화되는 단백질이다.

ZEB1(이전의 TCF8)은, IL2 전사 개시 ^[7]^[6]부위의 음의 조절 영역 100 뉴클레오티드 5-프라임에 결합하는 것으로, T림프구 고유의 IL2 유전자 발현을 억제하는 아연 핑거 및 호메오도메인 전사 인자를 부호화한다.ZEB1 및 그 포유동물 패럴로그 ZEB2는 호메오도메인 전사인자의 ZF(아연 핑거) 클래스 내 Zeb 패밀리에 속한다.ZEB1 단백질은 7개의 아연 손가락과 1개의 호메오도메인을 ^[8]가지고 있습니다.호메오도메인의 구조는 오른쪽에 표시되어 있습니다.

임상적 의의

유전자의 돌연변이는 후다형 각막디스트로피 3. ZEB1은 E-캐드헤린을 하향 조절하고 유방 및 기타 ^[9]암종에서 간엽성 전이를 유도한다.최근 연구는 폐암의 침윤성과 전이 ^[10]발달에 기여하는 역할을 제시했다.ZEB1은 BMP 억제제의 ^{[citation needed]}발현 유도를 통해 BMP 시그널링을 비활성화함으로써 유방암의 뼈 특이적 전이에 기여한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000148516 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000024238 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
^ ^a ^b Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. Bibcode:1991Sci...254.1791W. doi:10.1126/science.1840704. PMID 1840704.
^ ^a ^b "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
^ Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.
^ Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R. (March 2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene. 31, 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.{{cite journal}}: CS1 maint: 여러 이름: 작성자 목록(링크)
^ Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

추가 정보

Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (October 1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription". Molecular and Cellular Biology. 14 (10): 6773–88. doi:10.1128/MCB.14.10.6773. PMC 359208. PMID 7935395.
Watanabe Y, Kawakami K, Hirayama Y, Nagano K (December 1993). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene". Journal of Biochemistry. 114 (6): 849–55. doi:10.1093/oxfordjournals.jbchem.a124267. PMID 8138542.
Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (January 1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Molecular and Cellular Biology. 18 (1): 10–8. doi:10.1128/mcb.18.1.10. PMC 121442. PMID 9418848.
Turner J, Crossley M (September 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". The EMBO Journal. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
Postigo AA, Dean DC (June 1999). "ZEB represses transcription through interaction with the corepressor CtBP". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6683–8. Bibcode:1999PNAS...96.6683P. doi:10.1073/pnas.96.12.6683. PMC 21975. PMID 10359772.
Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T (April 2001). "Tip60 is a cell-type-specific transcriptional regulator". Journal of Biochemistry. 129 (4): 635–41. doi:10.1093/oxfordjournals.jbchem.a002901. PMID 11275565.
Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S (December 2001). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology". Journal of Bone and Mineral Research. 16 (12): 2192–204. doi:10.1359/jbmr.2001.16.12.2192. PMID 11760832. S2CID 25397480.
Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". Journal of Biomedical Science. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028.
Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J (October 2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression". The Journal of Biological Chemistry. 277 (42): 39209–16. doi:10.1074/jbc.M206400200. PMID 12161443.
Costantino ME, Stearman RP, Smith GE, Darling DS (August 2002). "Cell-specific phosphorylation of Zfhep transcription factor". Biochemical and Biophysical Research Communications. 296 (2): 368–73. doi:10.1016/S0006-291X(02)00880-X. PMC 3682420. PMID 12163027.
Postigo AA (May 2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway". The EMBO Journal. 22 (10): 2443–52. doi:10.1093/emboj/cdg225. PMC 155983. PMID 12743038.
Postigo AA, Depp JL, Taylor JJ, Kroll KL (May 2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins". The EMBO Journal. 22 (10): 2453–62. doi:10.1093/emboj/cdg226. PMC 155984. PMID 12743039.
Dillner NB, Sanders MM (January 2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades". DNA and Cell Biology. 23 (1): 25–34. doi:10.1089/104454904322745907. PMID 14965470.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Shimizu S, Krafchak C, Fuse N, Epstein MP, Schteingart MT, Sugar A, Eibschitz-Tsimhoni M, Downs CA, Rozsa F, Trager EH, Reed DM, Boehnke M, Moroi SE, Richards JE (November 2004). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10". American Journal of Medical Genetics. Part A. 130A (4): 372–7. doi:10.1002/ajmg.a.30267. PMC 1249494. PMID 15384081.
Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R (March 2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene. 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.

외부 링크

팩터북 ZEB1

인간 10번 염색체의 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000148516 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000024238 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427828-5] Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.

[pmid1840704-6] Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. Bibcode:1991Sci...254.1791W. doi:10.1126/science.1840704. PMID 1840704.

[entrez-7] "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".

[pmid26464018-8] Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.

[9] Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R. (March 2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene. 31, 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.{{cite journal}}: CS1 maint: 여러 이름: 작성자 목록(링크)

[pmid24468793-10] Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

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ZEB1

네임스페이스

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목차

임상적 의의

레퍼런스

추가 정보

외부 링크