E2F1

E2F1
E2F1
Protein E2F1 PDB 2aze.png
사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스E2F1, E2F-1, RBAP1, RBP3, RBP3, E2F 전사율 1
외부 IDOMIM: 18971 MGI: 101941 HomoloGene: 3828 GeneCard: E2F1
맞춤법
종.인간마우스
엔트레즈

1869

13555

앙상블

ENSG00000101412

ENSMUSG000027490

유니프로트

Q01094

Q61501

RefSeq(mRNA)

NM_005225

NM_007891
NM_001291105

RefSeq(단백질)

NP_005216

NP_001278034
NP_031917

장소(UCSC)Chr 20: 33.68 ~33.69 MbChr 2: 154.4 ~154.41 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

전사인자 E2F1은 인간에서 E2F1 유전자에 [5]의해 암호화되는 단백질이다.

기능.

이 유전자에 의해 암호화된 단백질은 전사 인자의 E2F 계열의 구성원이다.E2F 패밀리는 세포주기와 종양억제단백질의 작용 제어에 중요한 역할을 하며 작은 DNA 종양 바이러스의 변형단백질의 표적이 되기도 한다.E2F 단백질은 대부분의 가족 구성원에게서 발견되는 몇 가지 진화적으로 보존된 도메인을 포함합니다.이들 도메인은 DNA결합 도메인, 분화조절전사인자단백질(DP)과의 상호작용을 결정하는 이합체 도메인, 산성아미노산으로 농축된 트랜스액티베이션 도메인 및 트랜스액티베이션 도메인 내에 내장된 종양억제단백질 어소시에이션 도메인을 포함한다.이 단백질과 E2F2 및 E2F3의 다른 두 구성원은 추가적인 사이클린 결합 도메인을 가지고 있습니다.이 단백질은 세포 주기 의존적인 방식으로 망막아종 단백질 pRB에 우선적으로 결합한다.세포 증식과 p53 의존성/비의존성 아포토시스 [6]모두를 매개할 수 있다.

문자 변환

E2F1 프로모터[PAX8] => E2F1[7]

상호 작용

E2F1은 다음과 상호작용하는 것으로 나타났습니다.

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레퍼런스

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  2. ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027490 - 앙상블, 2017년 5월
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추가 정보

외부 링크

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.