SOX11
SOX11
전사인자 SOX-11은 SOX11 [5][6][7]유전자에 의해 인간에게 부호화되는 단백질이다.
기능.
이 인트론리스 유전자는 배아발달 조절 및 세포운명의 결정에 관여하는 그룹 CSOX(SRY 관련 HMG박스) 전사인자 패밀리의 멤버를 코드한다.암호화된 단백질은 다른 단백질과 단백질 복합체를 형성한 후 전사 조절기 역할을 할 수 있다.그 단백질은 발달하는 신경계에서 기능할 수 있고 종양 발생과 성인 신경 [7][8]발생에 역할을 할 수 있다.Sox11의 직접 타깃으로 Tuj1과 Tead2를 제안합니다.[9][10][11]
임상적 측면
SOX11 면역조직화학을 위한 림프구 염색은 다른 성숙한 림프종이나 정상 [12]림프구가 아닌 맨틀 세포 림프종(사이클린 D1 양성 및 음성)을 나타낸다.
SOX11의 돌연변이는 관-시리스[13] 증후군과 맨틀 세포 림프종과 [14]관련이 있다.
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레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000176887 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000063632 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Jay P, Gozé C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P (Sep 1995). "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics. 29 (2): 541–5. doi:10.1006/geno.1995.9970. PMID 8666406.
- ^ Wiebe MS, Nowling TK, Rizzino A (May 2003). "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". The Journal of Biological Chemistry. 278 (20): 17901–11. doi:10.1074/jbc.M212211200. PMID 12637543.
- ^ a b "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11".
- ^ Haslinger A, Schwarz TJ, Covic M, Lie DC (Jun 2009). "Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis". The European Journal of Neuroscience. 29 (11): 2103–14. doi:10.1111/j.1460-9568.2009.06768.x. PMID 19490090. S2CID 42742018.
- ^ Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J (Dec 2006). "The establishment of neuronal properties is controlled by Sox4 and Sox11". Genes & Development. 20 (24): 3475–86. doi:10.1101/gad.403406. PMC 1698453. PMID 17182872.
- ^ Bhattaram P, Penzo-Méndez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V (Apr 2010). "Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors". Nature Communications. 1 (1): 9. Bibcode:2010NatCo...1....9B. doi:10.1038/ncomms1008. PMC 2892298. PMID 20596238.
- ^ Larson BL, Ylostalo J, Lee RH, Gregory C, Prockop DJ (Nov 2010). "Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells". Tissue Engineering. Part A. 16 (11): 3385–94. doi:10.1089/ten.tea.2010.0085. PMC 2965191. PMID 20626275.
- ^ Anna Dusenbery, M.D., Mark R. Wick, M.D. "Stains & CD markers - SOX11". Pathology Outlines.
{{cite web}}: CS1 유지: 여러 이름: 작성자 목록(링크) 토픽 완료: 2018년 1월 1일.경미한 변경: 2021년 8월 12일 - ^ Tsurusaki Y, Koshimizu E, Ohashi H, Phadke S, Kou I, Shiina M, Suzuki T, Okamoto N, Imamura S, Yamashita M, Watanabe S, Yoshiura K, Kodera H, Miyatake S, Nakashima M, Saitsu H, Ogata K, Ikegawa S, Miyake N, Matsumoto N (2014). "De novo SOX11 mutations cause Coffin-Siris syndrome". Nature Communications. 5: 4011. Bibcode:2014NatCo...5.4011T. doi:10.1038/ncomms5011. PMID 24886874.
- ^ Vose, Julie M. (August 2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American Journal of Hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. ISSN 1096-8652. PMID 28699667.
추가 정보
- Wilson M, Koopman P (Aug 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
- Schepers GE, Teasdale RD, Koopman P (Aug 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
- Gozé C, Poulat F, Berta P (Jun 1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Research. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.
- Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M (Jun 1998). "Cooperative function of POU proteins and SOX proteins in glial cells". The Journal of Biological Chemistry. 273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID 9632656.
- Azuma T, Ao S, Saito Y, Yano K, Seki N, Wakao H, Masuho Y, Muramatsu M (Oct 1999). "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region". DNA Research. 6 (5): 357–60. doi:10.1093/dnares/6.5.357. PMID 10574465.
- Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ (May 2002). "Differential expression of SOX4 and SOX11 in medulloblastoma". Journal of Neuro-Oncology. 57 (3): 201–14. doi:10.1023/A:1015773818302. PMID 12125983. S2CID 20719302.
- Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM (Jul 2005). "Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells". Development. 132 (13): 3045–54. doi:10.1242/dev.01890. PMID 15944188.
- Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F (Nov 2005). "NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY". The Journal of Biological Chemistry. 280 (46): 38625–30. doi:10.1074/jbc.M504127200. PMID 16166090.
- DesGroseilliers M, Fortin F, Lemyre E, Lemieux N (2006). "Complex mosaicism in sex reversed SRY+ male twins". Cytogenetic and Genome Research. 112 (1–2): 176–9. doi:10.1159/000087532. PMID 16276109. S2CID 43826181.
외부 링크
