ETV4

ETV4
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	CO8×4, UUV×4
식별자
에일리어스	ETV4, E1A-F, E1AF, PEA3, PEAS3, ETS 바리안트4, ETS 바리안트 전사 팩터4
외부 ID	OMIM : 600711 MGI : 99423 HomoloGene : 1504 GenCard : ETV4
유전자 위치(인간)
크르.	17번 염색체(인간)
끝.	43,579,620 bp
유전자 위치(마우스)
크르.	11번 염색체(쥐)
끝.	101,676,196 bp
RNA발현패턴
	상단 표시 위치:
	뇌하수체; ; 뇌하수체 전엽; ; 심막; ; 니플; ; 상부 신경; ; 담낭; ; 사지 피부; ; 유즙관; ; 췌장체; ; 복부 피부;
	상단 표시 위치:
	미각; ; 입천장; ; 입술; ; 구개근; ; 장척근신장; ; 요도; ; 혀; ; 각막 간질; ; 남성 요도; ; 요도 상피;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; 배열특이적 DNA결합; DNA결합전사인자활성; DNA결합전사활성화제, RNA중합효소II 특이적; RNA중합효소II 시스조절영역배열특이적 DNA결합; 단백질 결합; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵소체; 핵소체; 핵;
생물학적 과정	세포 분화; 전사조절, DNA템플릿화; 전사, DNA 템플릿; RNA중합효소II에 의한 전사; RNA중합효소II에 의한 전사의 양성 조절; RNA중합효소II에 의한 전사조절;
	출처:아미고 / QuickGO
맞춤법
	2118
	18612
	ENSG00000175832
	ENSMUSG000017724
	P43268
	P28322
NM_001079675; NM_001261437; NM_001261438; NM_001261439; NM_001986;
	NM_001369366; NM_001369367; NM_001369368
	NM_008815; NM_001316365; NM_001316366
NP_001073143; NP_001248366; NP_001248367; NP_001248368; NP_001977;
	NP_001356295; NP_001356296; NP_0013567
	NP_001303294; NP_001303295; NP_032841
	위키데이터
인간 보기/편집	마우스 표시/편집

폴리오마 증강제 3(PEA3)이라고도 하는 ETS 전위 변형제 4(ETV4)는 ETS 전사 ^[5]^[6]^[7]인자의 PEA3 서브패밀리의 구성원이다.

질병 마커

ETV4와 관련된 두 가지 종류의 질병은 유잉 육종과 엑스트라 골수 육종이다.둘 다 암 종양이지만, 전자는 팔, 다리, 엉덩이, 척추에 가장 일반적으로 영향을 미치는 뼈에서 자라는 반면, 후자는 가슴, 발, 골반, 척추의 연조직에 영향을 미친다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000175832 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000017724 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Jul 1995). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics. 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID 8530053.
^ "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)".
^ "ETV4 Gene - GeneCards ETV4 Protein ETV4 Antibody". www.genecards.org. Retrieved 2019-10-20.

추가 정보

Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE (Jan 1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors". Genomics. 25 (1): 256–63. doi:10.1016/0888-7543(95)80133-7. PMID 7774926.
Liu SH, Peng BH, Ma JT, Liu YC, Ng SY (1995). "Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor". Developmental Genetics. 16 (3): 229–40. doi:10.1002/dvg.1020160303. PMID 7796532.
Friedman LS, Ostermeyer EA, Lynch ED, Szabo CI, Anderson LA, Dowd P, Lee MK, Rowell SE, Boyd J, King MC (Dec 1994). "The search for BRCA1". Cancer Research. 54 (24): 6374–82. PMID 7987831.
Higashino F, Yoshida K, Fujinaga Y, Kamio K, Fujinaga K (Feb 1993). "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family". Nucleic Acids Research. 21 (3): 547–53. doi:10.1093/nar/21.3.547. PMC 309151. PMID 8441666.
Urano F, Umezawa A, Hong W, Kikuchi H, Hata J (Feb 1996). "A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma". Biochemical and Biophysical Research Communications. 219 (2): 608–12. doi:10.1006/bbrc.1996.0281. PMID 8605035.
Coutte L, Monté D, Baert J, de Launoit Y (Nov 1999). "Genomic organization of the human e1af gene,a member of Ets transcription factors". Gene. 240 (1): 201–7. doi:10.1016/S0378-1119(99)00400-X. PMID 10564827.
Mastrangelo T, Modena P, Tornielli S, Bullrich F, Testi MA, Mezzelani A, Radice P, Azzarelli A, Pilotti S, Croce CM, Pierotti MA, Sozzi G (Aug 2000). "A novel zinc finger gene is fused to EWS in small round cell tumor". Oncogene. 19 (33): 3799–804. doi:10.1038/sj.onc.1203762. PMID 10949935.
Davidson B, Goldberg I, Gotlieb WH, Kopolovic J, Ben-Baruch G, Reich R (Apr 2003). "PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma". Clinical Cancer Research. 9 (4): 1412–9. PMID 12684413.
Span PN, Manders P, Heuvel JJ, Beex LV, Sweep CG (May 2003). "E1AF expression levels are not associated with prognosis in human breast cancer". Breast Cancer Research and Treatment. 79 (1): 129–31. doi:10.1023/A:1023338424677. PMID 12779089. S2CID 6629346.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Liu Y, Borchert GL, Phang JM (Apr 2004). "Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells". The Journal of Biological Chemistry. 279 (18): 18694–700. doi:10.1074/jbc.M308136200. PMID 14976201.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Davidson B, Goldberg I, Tell L, Vigdorchik S, Baekelandt M, Berner A, Kristensen GB, Reich R, Kopolovic J (2004). "The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions". Clinical & Experimental Metastasis. 21 (3): 191–9. doi:10.1023/B:CLIN.0000037703.37275.35. PMID 15387369. S2CID 22579184.
Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P, Van Seuningen I (Feb 2005). "The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells". The Biochemical Journal. 386 (Pt 1): 35–45. doi:10.1042/BJ20040706. PMC 1134764. PMID 15461591.
Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z, Yang Y, Niu Z, Liu W, Chen X, Hu Y, Gu J (Apr 2005). "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator". The Journal of Biological Chemistry. 280 (13): 12503–16. doi:10.1074/jbc.M413631200. PMID 15611127.
Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M (Feb 2005). "E1AF degradation by a ubiquitin-proteasome pathway". Biochemical and Biophysical Research Communications. 327 (2): 575–80. doi:10.1016/j.bbrc.2004.12.045. PMID 15629152.
Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K (May 2005). "Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis". Carcinogenesis. 26 (5): 892–9. CiteSeerX 10.1.1.567.1603. doi:10.1093/carcin/bgi029. PMID 15695237.

외부 링크

미국 국립 의학 도서관 의학 주제 제목(MeSH)의 ETV4+단백질, 인간
PDB for UniProt: P43268(ETS translocation variant 4)에서 PDBe-KB에 있는 모든 구조 정보의 개요.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

인간 염색체 17번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000175832 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000017724 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530053-5] Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Jul 1995). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics. 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID 8530053.

[6] "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)".

[7] "ETV4 Gene - GeneCards ETV4 Protein ETV4 Antibody". www.genecards.org. Retrieved 2019-10-20.

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ETV4

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질병 마커

레퍼런스

추가 정보

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