ILF2

ILF2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	4AT7, 4AT8, 4AT9, 4ATB
식별자
에일리어스	ILF2, NF45, PRO3063, 인터류킨증강제결합인자2
외부 ID	OMIM: 603181 MGI: 1915031 HomoloGene: 26894 GenCard: ILF2
유전자 위치(마우스)
크르.	3번 염색체(마우스)
끝.	90,395,686 bp
RNA발현패턴
	상단 표시 위치:
	신경절 융기; ; 랑게르한스 섬; ; 뇌하수체 전엽; ; 직장; ; 췌장체; ; 복부 피부; ; 갑상선 좌엽; ; 좌측 자궁관; ; 갑상선 우엽; ; 우부신;
	상단 표시 위치:
	신경절 융기; ; 신경관; ; 복벽; ; 내측 신경절 융기; ; 노른자낭; ; 손; ; 상악 융기; ; 상경부신경절; ; 소마이트; ; 진피;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	트랜스페라아제 활성; DNA결합; 이중가닥 RNA결합; 단백질 결합; ATP 결합; RNA결합;
셀룰러 컴포넌트	세포질; 핵소체; 막; 핵; 비과립내강; 제3과립내강; 피콜린1이 풍부한 과립 루멘; 세포외 영역; 리보핵단백질복합체;
생물학적 과정	전사의 양성 조절, DNA 템플릿화; 전사조절, DNA템플릿화; 면역 반응; 전사, DNA 템플릿; 호중구 탈과립;
	출처:아미고 / QuickGO
맞춤법
	3608
	67781
	없음
	ENSMUSG00000001016
	문제 12905
	Q9CXY6
	NM_004515; NM_001267809
	NM_026374
	NP_001254738; NP_004506
	NP_080650
	위키데이터
인간 보기/편집	마우스 표시/편집

인터류킨 인핸서 결합인자 2는 ILF2 ^[4]^[5]유전자에 의해 인체 내에서 부호화되는 단백질이다.

기능.

활성화된 T세포의 핵인자(NFAT)는 인터류킨2 유전자의 T세포 발현에 필요한 전사인자이다.NFAT는 항원 수용체 반응 요소 2로 알려진 인터류킨 2 유전자 증강제 중 배열에 결합한다.또한 NFAT는 RNA를 결합할 수 있으며 B형 간염 바이러스 중합효소의 캡슐화 및 단백질 프라이밍에 필수적인 성분이다.NFAT는 45kDa와 90kDa 단백질의 헤테로다이머이며, 그 중 작은 것이 이 유전자의 산물이다.암호화된 단백질은 90kDa 단백질에 강하게 결합하고 유전자 ^[5]발현을 강화하는 능력을 자극한다.

상호 작용

ILF2는 CDC5L^[6] 및 DNA-PKS와 ^[7]상호작용하는 것으로 나타났다.

ILF2와 ILF3는 루푸스 ^[8]^[9]유도 생쥐, 개 전신 류머티즘 자가면역질환 ^[10]^[11]및 자가면역질환을 ^[12]가진 인간에게서 드문 발견으로 확인되었다.

레퍼런스

^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001016 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (August 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry. 269 (32): 20691–9. doi:10.1016/S0021-9258(17)32048-3. PMID 7519613.
^ ^a ^b "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".
^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
^ Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
^ Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.
^ Kuroda Y, Ono N, Akaogi J, Nacionales DC, Yamasaki Y, Barker TT, Reeves WH, Satoh M (February 2006). "Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice". Toxicology. 218 (2–3): 186–96. doi:10.1016/j.tox.2005.10.011. PMID 16309812.
^ Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H (March 2018). "ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease". Scientific Reports. 8 (1): 4852. Bibcode:2018NatSR...8.4852B. doi:10.1038/s41598-018-23034-w. PMC 5859008. PMID 29556082.
^ Hanna, Bremer (2018). Canine immune-mediated disease. Acta Universitatis agriculturae Sueciae. ISBN 978-91-7760-166-1.
^ Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.

추가 정보

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Marcoulatos P, Koussidis G, Mamuris Z, Velissariou V, Vamvakopoulos NC (December 1996). "Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates". Journal of Interferon & Cytokine Research. 16 (12): 1035–8. doi:10.1089/jir.1996.16.1035. PMID 8974006.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR". Biochemistry. 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367.
Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Parker LM, Fierro-Monti I, Mathews MB (August 2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase". The Journal of Biological Chemistry. 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540.
Reichman TW, Muñiz LC, Mathews MB (January 2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Molecular and Cellular Biology. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Shin HJ, Kim SS, Cho YH, Lee SG, Rho HM (March 2002). "Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA". Archives of Virology. 147 (3): 471–91. doi:10.1007/s007050200001. PMID 11958450. S2CID 23653290.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Zhao G, Shi L, Qiu D, Hu H, Kao PN (May 2005). "NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function". Experimental Cell Research. 305 (2): 312–23. doi:10.1016/j.yexcr.2004.12.030. PMID 15817156.
Nie Y, Ding L, Kao PN, Braun R, Yang JH (August 2005). "ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing". Molecular and Cellular Biology. 25 (16): 6956–63. doi:10.1128/MCB.25.16.6956-6963.2005. PMC 1190226. PMID 16055709.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

외부 링크

ILF2+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)
PDBe-KB는 PDB for Mouse Interleukin Enhancer-binding factor 2(ILF2)에서 사용 가능한 모든 구조 정보의 개요를 제공합니다.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

인간 염색체 1번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCm38Ensembl-1] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001016 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7519613-4] Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (August 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry. 269 (32): 20691–9. doi:10.1016/S0021-9258(17)32048-3. PMID 7519613.

[entrez-5] "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".

[pmid11101529-6] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

[pmid9442054-7] Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.

[8] Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.

[9] Kuroda Y, Ono N, Akaogi J, Nacionales DC, Yamasaki Y, Barker TT, Reeves WH, Satoh M (February 2006). "Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice". Toxicology. 218 (2–3): 186–96. doi:10.1016/j.tox.2005.10.011. PMID 16309812.

[10] Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H (March 2018). "ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease". Scientific Reports. 8 (1): 4852. Bibcode:2018NatSR...8.4852B. doi:10.1038/s41598-018-23034-w. PMC 5859008. PMID 29556082.

[11] Hanna, Bremer (2018). Canine immune-mediated disease. Acta Universitatis agriculturae Sueciae. ISBN 978-91-7760-166-1.

[12] Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.

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Search

ILF2

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보

외부 링크