KLF10

KLF10
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2EPA
식별자
에일리어스	KLF10, EGR-alpha, EGRA, TIEG, TIEG1, 크루펠 유사 인자 10, 크루펠 유사 인자 10
외부 ID	OMIM: 601878 MGI: 1101353 HomoloGene: 4135 GeneCard: KLF10
유전자 위치(인간)
크르.	8번 염색체(인간)
끝.	102,655,725 bp
유전자 위치(마우스)
크르.	15번 염색체(쥐)
끝.	38,300,138 bp
RNA발현패턴
	상단 표시 위치:
	생식 상피; ; 위점막; ; 활액관절; ; 두정 흉막; ; 복정맥; ; 유즙관; ; 인간의 음경; ; 단구; ; 정강이뼈전근; ; 내장 흉막;
	상단 표시 위치:
	정자 세포; ; 요관; ; 방광; ; 좌폐엽; ; 신장 소체; ; 선조 혈관; ; 족저근; ; 흉선; ; 반잠금 밸브; ; 대동맥 판막;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; DNA결합전사인자활성; 금속 이온 결합; 단백질 결합; 핵산 결합; 코어프로모터배열특이DNA결합; RNA중합효소II 시스조절영역배열특이적 DNA결합; DNA결합전사활성화제, RNA중합효소II 특이적; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵;
생물학적 과정	골격계 발달; 골미네랄화; 펩타이드에 대한 세포 반응; 전사조절, DNA템플릿화; 체세포집단유지; 율동 과정; 세포신호; 골세포 분화의 양성 조절; RNA중합효소II에 의한 전사 음성 조절; 전사, DNA 템플릿; 일주 리듬; 세포군 증식; 형질전환성장인자β수용체신호경로; 세포군 증식의 음성 조절; 기아에 대한 세포 반응; 일주기 리듬 조절; 전사 음성 조절, DNA 템플릿; RNA중합효소II에 의한 전사; RNA중합효소II에 의한 전사의 양성 조절; RNA중합효소II에 의한 전사조절;
	출처:아미고 / QuickGO
맞춤법
	7071
	21847
	ENSG00000155090
	ENSMUSG000037465
	문제 13118
	O89091
	NM_001032282; NM_005655
	NM_001289471; NM_013692; NM_00135767
	NP_001027453; NP_005646
	NP_001276400; NP_038720; NP_001344606
	위키데이터
인간 보기/편집	마우스 표시/편집

크루펠 유사인자 10은 KLF10 ^[5]^[6]^[7]유전자에 의해 인체 내에서 코드되는 단백질이다.

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크루펠 유사 인자

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000155090 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000037465 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Blok LJ, Grossmann ME, Perry JE, Tindall DJ (Mar 1996). "Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation". Mol Endocrinol. 9 (11): 1610–20. doi:10.1210/mend.9.11.8584037. PMID 8584037.
^ Fautsch MP, Vrabel A, Subramaniam M, Hefferen TE, Spelsberg TC, Wieben ED (Oct 1998). "TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters". Genomics. 51 (3): 408–16. doi:10.1006/geno.1998.5388. PMID 9721211.
^ "Entrez Gene: KLF10 Kruppel-like factor 10".

추가 정보

Subramaniam M, Harris SA, Oursler MJ, et al. (1996). "Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts". Nucleic Acids Res. 23 (23): 4907–12. doi:10.1093/nar/23.23.4907. PMC 307482. PMID 8532536.
Tachibana I, Imoto M, Adjei PN, et al. (1997). "Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells". J. Clin. Invest. 99 (10): 2365–74. doi:10.1172/JCI119418. PMC 508075. PMID 9153278.
Subramaniam M, Hefferan TE, Tau K, et al. (1998). "Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene". J. Cell. Biochem. 68 (2): 226–36. doi:10.1002/(SICI)1097-4644(19980201)68:2<226::AID-JCB9>3.0.CO;2-X. PMID 9443078.
Cook T, Gebelein B, Mesa K, et al. (1998). "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth". J. Biol. Chem. 273 (40): 25929–36. doi:10.1074/jbc.273.40.25929. PMID 9748269.
Hefferan TE, Reinholz GG, Rickard DJ, et al. (2000). "Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells". J. Biol. Chem. 275 (27): 20255–9. doi:10.1074/jbc.C000135200. PMID 10816551.
Gunther M, Laithier M, Brison O (2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
Antonello D, Moore PS, Zamboni G, et al. (2002). "Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer". Cancer Lett. 183 (2): 179–83. doi:10.1016/S0304-3835(01)00802-3. PMID 12065093.
Johnsen SA, Subramaniam M, Monroe DG, et al. (2002). "Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue". J. Biol. Chem. 277 (34): 30754–9. doi:10.1074/jbc.M204812200. PMID 12072443.
Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC (2002). "TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses". Oncogene. 21 (37): 5783–90. doi:10.1038/sj.onc.1205681. PMID 12173049.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chrisman HR, Tindall DJ (2003). "Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha". DNA Cell Biol. 22 (3): 187–99. doi:10.1089/104454903321655819. PMID 12804117.
Noti JD, Johnson AK, Dillon JD (2004). "The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter". J. Biol. Chem. 279 (26): 26948–58. doi:10.1074/jbc.M310634200. PMID 15087465.
Reinholz MM, An MW, Johnsen SA, et al. (2004). "Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue". Breast Cancer Res. Treat. 86 (1): 75–88. doi:10.1023/B:BREA.0000032926.74216.7d. PMID 15218362. S2CID 25869980.
Johnsen SA, Subramaniam M, Effenberger KE, Spelsberg TC (2004). "The TGFβ Inducible Early Gene Plays a Central Role in the Anti-Proliferative Response to TGFβ". Signal Transduction. 4: 29–35. doi:10.1002/sita.200400032.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JM, Turner RT, Oursler MJ, Spelsberg TC (2005). "TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro". Mol. Cell. Biol. 25 (3): 1191–1199. doi:10.1128/MCB.25.3.1191-1199.2005. PMC 543998. PMID 15657444.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Fueki N, Sagara H, Akimoto K, et al. (2007). "Interleukin-10 regulates transforming growth factor-beta signaling in cultured human bronchial epithelial cells". Respiration; International Review of Thoracic Diseases. 74 (4): 454–9. doi:10.1159/000101057. PMID 17377371. S2CID 20399180.
Jin W, Di G, Li J, et al. (2007). "TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade". FEBS Lett. 581 (20): 3826–32. doi:10.1016/j.febslet.2007.07.008. PMID 17659279. S2CID 20445009.
Subramaniam M, Hawse JR, Johnsen SA, Spelsberg TC (2007). "TIEG1: An Important Regulator of Multiple Biological Processes and Disease States". J. Cell. Biochem. 102 (3): 539–548. doi:10.1002/jcb.21492. PMID 17729309. S2CID 42592049.

외부 링크

KLF10+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

인간 염색체 8번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000155090 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000037465 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8584037-5] Blok LJ, Grossmann ME, Perry JE, Tindall DJ (Mar 1996). "Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation". Mol Endocrinol. 9 (11): 1610–20. doi:10.1210/mend.9.11.8584037. PMID 8584037.

[pmid9721211-6] Fautsch MP, Vrabel A, Subramaniam M, Hefferen TE, Spelsberg TC, Wieben ED (Oct 1998). "TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters". Genomics. 51 (3): 408–16. doi:10.1006/geno.1998.5388. PMID 9721211.

[entrez-7] "Entrez Gene: KLF10 Kruppel-like factor 10".

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