PRRX1

PRRX1
식별자
에일리어스	PRRX1, AGOTC, PHOX1, PMX1, PRX-1, PRX1, 쌍으로 연결된 호메오박스1
외부 ID	OMIM: 167420 MGI: 97712 HomoloGene: 7896 GeneCard: PRRX1
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	170,739,421 bp
유전자 위치(마우스)
크르.	1번 염색체(마우스)
끝.	163,162,279 bp
RNA발현패턴
	상단 표시 위치:
	아킬레스건; ; 요도; ; 복정맥; ; 두정 흉막; ; 활액관절; ; 대정맥; ; 심막; ; 정낭포; ; 자궁내막간질세포; ; 외음부;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	배열특이적 DNA결합; GO:0001105 트랜스크립션코액티베이터 액티비티; DNA결합; HMG 박스 도메인 바인딩; GO:0000980 RNA중합효소II 시스조절영역배열특이적 DNA결합; GO:0001078, GO:0001214, GO:0001206 DNA결합전사억제제활성, RNA중합효소II 특이적; GO:0001200, GO:0001133, GO:0001201 DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵; 핵소체; 세포;
생물학적 과정	배아 골격계 형태 형성; 입천장 발달; 전사조절, DNA템플릿화; 뉴런 운명 결정; 평활화된 신호 경로의 양성 조절; 뉴런투영재생조절; RNA중합효소II에 의한 전사 음성 조절; 신경줄기세포집단유지; 다세포 생물 발달; 연골 발달; 간엽세포증식의 양성조절; 태아 사지 형태 형성; 내이 형태 형성; 동맥 형태 형성; 중이 형태 형성; 배아 두개 골격 형태 형성; RNA중합효소II에 의한 전사의 양성 조절; RNA중합효소II에 의한 전사;
	출처:아미고 / QuickGO
맞춤법
	5396
	18933
	ENSG00000116132
	ENSMUSG000026586
	P54821
	P63013
	NM_006902; NM_022716
	NM_001025570; NM_011127; NM_175686
	NP_008833; NP_073207
	NP_001020741; NP_035257; NP_783617
	위키데이터
인간 보기/편집	마우스 표시/편집

짝지어진 관련 호메오박스 1은 PRRX1 ^[5]^[6]유전자에 의해 인체 내에서 코드되는 단백질이다.

기능.

이 유전자에 의해 코드된 DNA 관련 단백질은 핵에 국소화된 호메오박스 단백질의 쌍체 계열의 구성원이다.단백질은 성장 및 분화 인자에 의한 유전자 유도에 필요한 단백질인 혈청 반응 인자의 DNA 결합 활성을 강화하면서 전사 공활성제 역할을 한다.단백질은 근육 크레아틴 키나제를 조절하여 다양한 중배엽 근육 유형을 확립하는 역할을 나타냅니다.대체 스플라이싱은 풍부함 및 ^[6]발현 패턴이 다른 두 개의 아이소폼을 생성합니다.

간엽 줄기세포 분화에 대한 역할

Prrx1 발현은 배아발달 중 중배엽에 제한되며 Prrx1과 Prrx2는 모두 성체 ^[7]^[8]^[9]^[10]^[11]생쥐의 간엽조직에서 발현된다.Prrx1과 Prrx2가 모두 부족한 생쥐는 두개 안면 영역의 ^[9]^[12]간엽 세포 분화에 심각한 결함이 있다.몇몇 최근의 연구는 PRRX1이 간엽 전구체의 분화를 조절할 수 있다는 것을 보여준다.예를 들어 PRRX1은 형질전환성장인자-베타(TGF-베타)^[13] 시그널링을 활성화함으로써 지방형성을 억제하고 종양괴사인자-알파 하류에 작용하여 골아세포 ^[14]분화를 억제한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000116132 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026586 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grueneberg DA, Natesan S, Alexandre C, Gilman MZ (Sep 1992). "Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor". Science. 257 (5073): 1089–95. Bibcode:1992Sci...257.1089G. doi:10.1126/science.257.5073.1089. PMID 1509260. S2CID 1206059.
^ ^a ^b "Entrez Gene: PRRX1 paired related homeobox 1".
^ Kern MJ, Witte DP, Valerius MT, Aronow BJ, Potter SS (October 1992). "A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy". Nucleic Acids Res. 20 (19): 5189–95. doi:10.1093/nar/20.19.5189. PMC 334304. PMID 1383943.
^ Nohno T, Koyama E, Myokai F, Taniguchi S, Ohuchi H, Saito T, Noji S (July 1993). "A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb". Dev. Biol. 158 (1): 254–64. doi:10.1006/dbio.1993.1184. PMID 8101172.
^ ^a ^b Lu MF, Cheng HT, Kern MJ, Potter SS, Tran B, Diekwisch TG, Martin JF (February 1999). "prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme" (PDF). Development. 126 (3): 495–504. doi:10.1242/dev.126.3.495. hdl:1969.1/184860. PMID 9876178.
^ Hu YS, Zhou H, Kartsogiannis V, Eisman JA, Martin TJ, Ng KW (November 1998). "Expression of rat homeobox gene, rHOX, in developing and adult tissues in mice and regulation of its mRNA expression in osteoblasts by bone morphogenetic protein 2 and parathyroid hormone-related protein". Mol. Endocrinol. 12 (11): 1721–32. doi:10.1210/mend.12.11.0195. PMID 9817598.
^ Cserjesi P, Lilly B, Bryson L, Wang Y, Sassoon DA, Olson EN (August 1992). "MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer". Development. 115 (4): 1087–101. doi:10.1242/dev.115.4.1087. PMID 1360403.
^ ten Berge D, Brouwer A, Korving J, Martin JF, Meijlink F (October 1998). "Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs". Development. 125 (19): 3831–42. doi:10.1242/dev.125.19.3831. hdl:1969.1/184321. PMID 9729491.
^ Du B, Cawthorn WP, Su A, Doucette CR, Yao Y, Hemati N, Kampert S, McCoin C, Broome DT, Rosen CJ, Yang G, MacDougald OA (February 2013). "The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling". J. Biol. Chem. 288 (5): 3036–47. doi:10.1074/jbc.M112.440370. PMC 3561528. PMID 23250756.
^ Lu X, Beck GR, Gilbert LC, Camalier CE, Bateman NW, Hood BL, Conrads TP, Kern MJ, You S, Chen H, Nanes MS (January 2011). "Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation". J. Bone Miner. Res. 26 (1): 209–19. doi:10.1002/jbmr.203. PMC 3179318. PMID 20683885.

추가 정보

Grueneberg DA, Simon KJ, Brennan K, Gilman M (1995). "Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins". Mol. Cell. Biol. 15 (6): 3318–26. doi:10.1128/MCB.15.6.3318. PMC 230565. PMID 7760827.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Grueneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M (October 1997). "A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes Dev. 11 (19): 2482–93. doi:10.1101/gad.11.19.2482. PMC 316568. PMID 9334314.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nakamura T, Yamazaki Y, Hatano Y, Miura I (1999). "NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)". Blood. 94 (2): 741–7. doi:10.1182/blood.V94.2.741. PMID 10397741.
Kataoka K, Yoshitomo-Nakagawa K, Shioda S, Nishizawa M (2001). "A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities". J. Biol. Chem. 276 (1): 819–26. doi:10.1074/jbc.M007643200. PMID 11036080.
Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (November 2000). "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome". Mamm. Genome. 11 (11): 1000–5. doi:10.1007/s003350010193. PMID 11063257. S2CID 9937434.
Jones FS, Meech R, Edelman DB, Oakey RJ, Jones PL (July 2001). "Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease". Circ. Res. 89 (2): 131–8. doi:10.1161/hh1401.093582. PMID 11463719.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, et al. (May 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Kim YJ, Ahn JY, Liang P, Ip C, Zhang Y, Park YM (January 2007). "Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology". Cancer Res. 67 (2): 546–54. doi:10.1158/0008-5472.CAN-06-2401. PMID 17234762.

외부 링크

PRRX1+단백질+미국국립의학도서관 의학 과목 제목(MeSH)

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000116132 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000026586 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1509260-5] Grueneberg DA, Natesan S, Alexandre C, Gilman MZ (Sep 1992). "Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor". Science. 257 (5073): 1089–95. Bibcode:1992Sci...257.1089G. doi:10.1126/science.257.5073.1089. PMID 1509260. S2CID 1206059.

[entrez-6] "Entrez Gene: PRRX1 paired related homeobox 1".

[pmid1383943-7] Kern MJ, Witte DP, Valerius MT, Aronow BJ, Potter SS (October 1992). "A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy". Nucleic Acids Res. 20 (19): 5189–95. doi:10.1093/nar/20.19.5189. PMC 334304. PMID 1383943.

[pmid8101172-8] Nohno T, Koyama E, Myokai F, Taniguchi S, Ohuchi H, Saito T, Noji S (July 1993). "A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb". Dev. Biol. 158 (1): 254–64. doi:10.1006/dbio.1993.1184. PMID 8101172.

[pmid9876178-9] Lu MF, Cheng HT, Kern MJ, Potter SS, Tran B, Diekwisch TG, Martin JF (February 1999). "prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme" (PDF). Development. 126 (3): 495–504. doi:10.1242/dev.126.3.495. hdl:1969.1/184860. PMID 9876178.

[pmid9817598-10] Hu YS, Zhou H, Kartsogiannis V, Eisman JA, Martin TJ, Ng KW (November 1998). "Expression of rat homeobox gene, rHOX, in developing and adult tissues in mice and regulation of its mRNA expression in osteoblasts by bone morphogenetic protein 2 and parathyroid hormone-related protein". Mol. Endocrinol. 12 (11): 1721–32. doi:10.1210/mend.12.11.0195. PMID 9817598.

[pmid1360403-11] Cserjesi P, Lilly B, Bryson L, Wang Y, Sassoon DA, Olson EN (August 1992). "MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer". Development. 115 (4): 1087–101. doi:10.1242/dev.115.4.1087. PMID 1360403.

[pmid9729491-12] ten Berge D, Brouwer A, Korving J, Martin JF, Meijlink F (October 1998). "Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs". Development. 125 (19): 3831–42. doi:10.1242/dev.125.19.3831. hdl:1969.1/184321. PMID 9729491.

[pmid23250756-13] Du B, Cawthorn WP, Su A, Doucette CR, Yao Y, Hemati N, Kampert S, McCoin C, Broome DT, Rosen CJ, Yang G, MacDougald OA (February 2013). "The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling". J. Biol. Chem. 288 (5): 3036–47. doi:10.1074/jbc.M112.440370. PMC 3561528. PMID 23250756.

[pmid20683885-14] Lu X, Beck GR, Gilbert LC, Camalier CE, Bateman NW, Hood BL, Conrads TP, Kern MJ, You S, Chen H, Nanes MS (January 2011). "Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation". J. Bone Miner. Res. 26 (1): 209–19. doi:10.1002/jbmr.203. PMC 3179318. PMID 20683885.

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PRRX1

네임스페이스

더

목차

기능.

간엽 줄기세포 분화에 대한 역할

레퍼런스

추가 정보

외부 링크