호모 사피엔스 종의 단백질 코드 유전자
미엘린 전사인자 1은 인간의 MYT1 [5] [6] [7] 유전자에 의해 암호화되는 단백질 이다.
기능. 이 유전자에 의해 암호화된 단백질은 신경 특이적이고 아연 손가락을 포함하는 DNA 결합 단백질의 일원입니다. 단백질은 중추신경계의 단백질 프로모터 영역에 결합하고 신경계를 [7] 발달시키는 역할을 합니다.
인터랙티브 패스 맵 관련 기사를 방문하려면 아래의 유전자, 단백질, 대사물을 클릭하세요. [§ 1]
^ 대화형 경로 맵은 WikiPathways에서 편집할 수 있습니다. "WP3584" .
상호 작용 MYT1은 PIN1 과 [8] 상호 작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000196132 - 앙상블 , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000010505 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Kim JG, Hudson LD (December 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene" . Molecular and Cellular Biology . 12 (12): 5632–9. doi :10.1128/mcb.12.12.5632 . PMC 360502 . PMID 1280325 . ^ Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity" . The Journal of Biological Chemistry . 272 (35): 22300–6. doi :10.1074/jbc.272.35.22300 . PMID 9268380 . ^ a b "Entrez Gene: MYT1 myelin transcription factor 1" . ^ Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (October 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science . 112 (19): 3361–71. doi :10.1242/jcs.112.19.3361 . PMID 10504341 .
추가 정보 Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M (August 1994). "Plasticity in the adult human oligodendrocyte lineage" . The Journal of Neuroscience . 14 (8): 4571–87. doi :10.1523/JNEUROSCI.14-08-04571.1994 . PMC 6577192 . PMID 7519254 . Armstrong RC, Kim JG, Hudson LD (August 1995). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia . 14 (4): 303–21. doi :10.1002/glia.440140407 . PMID 8530187 . S2CID 38779689 . Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (February 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex" . Molecular and Cellular Biology . 17 (2): 571–83. doi :10.1128/mcb.17.2.571 . PMC 231782 . PMID 9001210 . Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD (October 1997). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system" . Journal of Neuroscience Research . 50 (2): 272–90. doi :10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A . PMID 9373037 . Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 5 (6): 355–64. doi :10.1093/dnares/5.6.355 . PMID 10048485 . Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 6 (3): 197–205. doi :10.1093/dnares/6.3.197 . PMID 10470851 . Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S (January 2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Research. Developmental Brain Research . 140 (1): 85–92. doi :10.1016/S0165-3806(02)00585-0 . PMID 12524179 . Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (January 2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Molecular and Cellular Neurosciences . 25 (1): 111–23. doi :10.1016/j.mcn.2003.10.001 . PMID 14962745 . S2CID 28151272 . Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (May 2007). "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS" . Glia . 55 (7): 687–97. doi :10.1002/glia.20492 . PMC 2789289 . PMID 17330875 . 외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY