호모 사피엔스 종의 단백질 코드 유전자
전사인자 E2F3 는 인간 에서 E2F3 유전자에 [5] 단백질 이다.
기능. 이 유전자에 의해 암호화된 단백질은 전사 인자의 E2F 계열의 구성원이다. E2F 패밀리는 세포주기와 종양억제단백질의 작용 제어에 중요한 역할을 하며 작은 DNA 종양 바이러스의 변형단백질의 표적이 되기도 한다. E2F 단백질은 대부분의 가족 구성원에게서 발견되는 몇 가지 진화적으로 보존된 도메인을 포함합니다. 이들 도메인은 DNA결합 도메인, 분화조절전사인자단백질(DP)과의 상호작용을 결정하는 이합체 도메인, 산성아미노산으로 농축된 트랜스액티베이션 도메인 및 트랜스액티베이션 도메인 내에 내장된 종양억제단백질 어소시에이션 도메인을 포함한다. 이 단백질과 다른 두 구성원인 E2F1과 E2F2는 추가적인 사이클린 결합 도메인을 가지고 있다. 이 단백질은 세포 주기 의존적인 방식으로 망막아종 단백질 pRB에 특이적으로 결합합니다. 대체 유전자 스플라이싱은 마우스 호몰로그에서 발견되지만 [6]
상호 작용 E2F3는 TFE3 [7] 및 [8] 것 으로 나타났습니다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000112242 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000016477 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Dec 1993). "The retinoblastoma protein binds to a family of E2F transcription factors" . Molecular and Cellular Biology . 13 (12): 7813–25. doi :10.1128/mcb.13.12.7813 . PMC 364853 PMID 8246996 . ^ "Entrez Gene: E2F3 E2F transcription factor 3" .^ Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR (Jun 2003). "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor" . Molecular and Cellular Biology . 23 (11): 3707–20. doi :10.1128/MCB.23.11.3707-3720.2003 . PMC 155231 PMID 12748276 . ^ Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function" . The EMBO Journal . 21 (21): 5775–86. doi :10.1093/emboj/cdf577 . PMC 131074 PMID 12411495 .
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(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY
