LYL1

LYL1
식별자
에일리어스	LYL1, bHLHa18, 림프아구성 백혈병 관련 조혈조절제1, 염기성 헬릭스 패밀리, LYL1 염기성 헬릭스 패밀리
외부 ID	OMIM: 151440 MGI: 96891 HomoloGene: 4078 GeneCard: LYL1
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	13,170,180 bp
유전자 위치(마우스)
크르.	8번 염색체(쥐)
끝.	85,431,569 bp
RNA발현패턴
	상단 표시 위치:
	피; ; 단구; ; 결석골; ; 골수; ; 비장; ; 골수 세포; ; 대정맥; ; 천측두동맥; ; 림프절; ; 부록;
	상단 표시 위치:
	비장; ; 골수; ; 피; ; 심실중격; ; 심내막 쿠션; ; 노른자낭; ; 내경동맥; ; 암요도; ; 피하 지방 조직; ; 발목;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; RNA중합효소II전사조절영역배열특이적DNA결합; 단백질 결합; 단백질 이량화 활성; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵;
생물학적 과정	전사의 양성 조절, DNA 템플릿화; B세포분화; 결정적 조혈; 전사조절, DNA템플릿화; 전사, DNA 템플릿; 혈관 성숙; RNA중합효소II에 의한 전사조절;
	출처:아미고 / QuickGO
맞춤법
	4066
	17095
	ENSG00000104903
	ENSMUSG000034041
	P12980
	P27792
	NM_005583
	NM_008535
	NP_005574
	NP_032561
	위키데이터
인간 보기/편집	마우스 표시/편집

단백질 라일-1은 LYL1 ^[5]^[6]유전자에 의해 인간에게 암호화되는 단백질이다.

상호 작용

LYL1은 TCF3^[7] 및 NFKB1과 ^[8]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000104903 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000034041 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424. S2CID 24737263.
^ "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".
^ Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
^ Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.

추가 정보

Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proceedings of the National Academy of Sciences of the United States of America. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
Kuo SS, Mellentin JD, Copeland NG, Gilbert DJ, Jenkins NA, Cleary ML (June 1991). "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene". Oncogene. 6 (6): 961–8. PMID 2067848.
Saltman DL, Mellentin JD, Smith SD, Cleary ML (November 1990). "Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization". Genes, Chromosomes & Cancer. 2 (4): 259–65. doi:10.1002/gcc.2870020402. PMID 2268576. S2CID 103922.
Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". The EMBO Journal. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (January 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
Mahajan MA, Park ST, Sun XH (June 1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID 8649774.
Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.
Meng YS, Khoury H, Dick JE, Minden MD (November 2005). "Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia". Leukemia. 19 (11): 1941–7. doi:10.1038/sj.leu.2403836. PMID 16094422.

외부 링크

LYL1+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)

인간 염색체 19번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000104903 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000034041 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2752424-5] Mellentin JD, Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424. S2CID 24737263.

[entrez-6] "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".

[pmid8628307-7] Miyamoto A, Cui X, Naumovski L, Cleary ML (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Molecular and Cellular Biology. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.

[pmid10023675-8] Ferrier R, Nougarede R, Doucet S, Kahn-Perles B, Imbert J, Mathieu-Mahul D (January 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

Search

LYL1

네임스페이스

더

목차

상호 작용

레퍼런스

추가 정보

외부 링크