호모 사피엔스 종의 단백질 코드 유전자
T세포 백혈병 호메오박스 단백질 3은 TLX3 [5] [6] [7] 단백질 이다.
RNX(HOX11L2, TLX3)는 DNA 결합 핵전사인자를 코드하는 고아 호메오박스 유전자군에 속합니다. HOX11 유전자 패밀리 구성원은 고도로 보존된 호메오도메인 에서 시토신을 대체 하는 트레오닌-47로 특징지어진다(Dear et al., 1993) [OMIM [7]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000164438 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000040610 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M (Jul 2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping" . Cytogenet Cell Genet . 92 (3–4): 358. doi :10.1159/000056933 . PMID 11435718 . S2CID 85323468 . ^ Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I (Jul 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet Cell Genet . 92 (3–4): 354–5. doi :10.1159/000056931 . PMID 11435716 . S2CID 35224759 . ^ a b "Entrez Gene: TLX3 T-cell leukemia homeobox 3" . 추가 정보 Dear TN, Sanchez-Garcia I, Rabbitts TH (1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes" . Proc. Natl. Acad. Sci. U.S.A . 90 (10): 4431–5. doi :10.1073/pnas.90.10.4431 PMC 46525 PMID 8099440 . Bernard OA, Busson-LeConiat M, Ballerini P, et al. (2002). "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia" . Leukemia . 15 (10): 1495–504. doi :10.1038/sj.leu.2402249 PMID 11587205 . Ballerini P, Blaise A, Busson-Le Coniat M, et al. (2002). "HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis". Blood . 100 (3): 991–7. doi :10.1182/blood-2001-11-0093 . PMID 12130513 . Matera I, Bachetti T, Cinti R, et al. (2003). "Mutational analysis of the RNX gene in congenital central hypoventilation syndrome". Am. J. Med. Genet . 113 (2): 178–82. doi :10.1002/ajmg.10746 . PMID 12407709 . Mauvieux L, Leymarie V, Helias C, et al. (2003). "High incidence of Hox11L2 expression in children with T-ALL" . Leukemia . 16 (12): 2417–22. doi :10.1038/sj.leu.2402709 PMID 12454747 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Berger R, Dastugue N, Busson M, et al. (2003). "t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)" . Leukemia . 17 (9): 1851–7. doi :10.1038/sj.leu.2403061 PMID 12970786 . Cavé H, Suciu S, Preudhomme C, et al. (2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951" . Blood . 103 (2): 442–50. doi :10.1182/blood-2003-05-1495 PMID 14504110 . Su XY, Busson M, Della Valle V, et al. (2004). "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia". Genes Chromosomes Cancer . 41 (3): 243–9. doi :10.1002/gcc.20088 . PMID 15334547 . S2CID 19782389 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ballerini P, Busson M, Fasola S, et al. (2005). "NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance" . Leukemia . 19 (3): 468–70. doi :10.1038/sj.leu.2403654 PMID 15674415 . Gottardo NG, Jacoby PA, Sather HN, et al. (2005). "Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols" . Leukemia . 19 (9): 1705–8. doi :10.1038/sj.leu.2403834 PMID 15990867 . Borghini S, Vargiolu M, Di Duca M, et al. (2006). "Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia" . Mol. Cancer Res . 4 (9): 635–43. doi :10.1158/1541-7786.MCR-05-0250 PMID 16966433 . Nagel S, Scherr M, Kel A, et al. (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1" . Cancer Res . 67 (4): 1461–71. doi :10.1158/0008-5472.CAN-06-2615 PMID 17308084 .
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY
