호모 사피엔스 종의 단백질 코드 유전자
암 1 단백질의 과메틸화 단백질은 [5] HIC1 유전자에 의해 인체에서 암호화되는 단백질 이다.
레퍼런스 추가 정보 Chopin V, Leprince D (2006). "[Chromosome arm 17p13.3: could HIC1 be the one ?]" . Med Sci (Paris) . 22 (1): 54–61. doi :10.1051/medsci/200622154 . PMID 16386221 . Wales MM, Biel MA, el Deiry W, et al. (1995). "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3". Nat. Med . 1 (6): 570–7. doi :10.1038/nm0695-570 . PMID 7585125 . S2CID 21993943 . Fujii H, Biel MA, Zhou W, et al. (1998). "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer" . Oncogene . 16 (16): 2159–64. doi :10.1038/sj.onc.1201976 . PMID 9572497 . Deltour S, Guerardel C, Stehelin D, Leprince D (1999). "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved". Biochim. Biophys. Acta . 1443 (1–2): 230–2. doi :10.1016/s0167-4781(98)00219-x . PMID 9838134 . Deltour S, Guerardel C, Leprince D (2000). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B" . Proc. Natl. Acad. Sci. U.S.A . 96 (26): 14831–6. doi :10.1073/pnas.96.26.14831 . PMC 24733 . PMID 10611298 . Guerardel C, Deltour S, Pinte S, et al. (2001). "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53" . J. Biol. Chem . 276 (5): 3078–89. doi :10.1074/jbc.M008690200 . PMID 11073960 . Deltour S, Pinte S, Guérardel C, Leprince D (2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem. Biophys. Res. Commun . 287 (2): 427–34. doi :10.1006/bbrc.2001.5624 . PMID 11554746 . Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif" . Mol. Cell. Biol . 22 (13): 4890–901. doi :10.1128/MCB.22.13.4890-4901.2002 . PMC 133903 . PMID 12052894 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 . Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3" . Am. J. Hum. Genet . 72 (4): 918–30. doi :10.1086/374320 . PMC 1180354 . PMID 12621583 . Rathi A, Virmani AK, Harada K, et al. (2004). "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms". Clin. Cancer Res . 9 (10 Pt 1): 3674–8. PMID 14506157 . Waha A, Waha A, Koch A, et al. (2004). "Epigenetic silencing of the HIC-1 gene in human medulloblastomas" . J. Neuropathol. Exp. Neurol . 62 (11): 1192–201. doi :10.1093/jnen/62.11.1192 . PMID 14656076 . Lindsey JC, Lusher ME, Anderton JA, et al. (2004). "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling" . Carcinogenesis . 25 (5): 661–8. doi :10.1093/carcin/bgh055 . PMID 14688019 . Pinte S, Guérardel C, Deltour-Balerdi S, et al. (2004). "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1" . Oncogene . 23 (22): 4023–31. doi :10.1038/sj.onc.1207504 . PMID 15007385 . Pinte S, Stankovic-Valentin N, Deltour S, et al. (2004). "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties" . J. Biol. Chem . 279 (37): 38313–24. doi :10.1074/jbc.M401610200 . PMID 15231840 . Chen W, Cooper TK, Zahnow CA, et al. (2004). "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis" . Cancer Cell . 6 (4): 387–98. doi :10.1016/j.ccr.2004.08.030 . PMID 15488761 . Britschgi C, Rizzi M, Grob TJ, et al. (2006). "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1" . Oncogene . 25 (14): 2030–9. doi :10.1038/sj.onc.1209240 . PMID 16301995 . Valenta T, Lukas J, Doubravska L, et al. (2006). "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies" . EMBO J . 25 (11): 2326–37. doi :10.1038/sj.emboj.7601147 . PMC 1478201 . PMID 16724116 . Stankovic-Valentin N, Verger A, Deltour-Balerdi S, et al. (2006). "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP" . FEBS J . 273 (13): 2879–90. doi :10.1111/j.1742-4658.2006.05301.x . PMID 16762039 . S2CID 34249691 .
외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY