ING1

ING1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2분기
식별자
에일리어스	ING1, p24ING1c, p33, p33p33ING1b, p47, p47ING1a, 성장 패밀리 멤버 1의 억제제
외부 ID	OMIM: 601566 MGI: 1349481 HomoloGene: 40119 GeneCard: ING1
유전자 위치(인간)
크르.	13번 염색체(인간)
끝.	110,723,339 bp
유전자 위치(마우스)
크르.	8번 염색체(쥐)
끝.	11,613,251 bp
RNA발현패턴
	상단 표시 위치:
	자궁내막간질세포; ; 신경절 융기; ; 단구; ; 내피 세포; ; 피; ; 기관지 상피 세포; ; 이하선; ; 후생 사구체; ; 이차 난모세포; ; 상부 신경;
	상단 표시 위치:
	원시적 특징; ; 이차 난모세포; ; 요관; ; 혈관 형성; ; 수채관; ; 복벽; ; 결막공; ; 흉선; ; 섬모체; ; 밧세루;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	메틸화히스톤결합; 단백질 결합; 금속 이온 결합;
셀룰러 컴포넌트	핵;
생물학적 과정	세포사 조절; 세포 주기; 세포 증식의 음성 조절; 세포군 증식의 음성 조절; 전사의 양성 조절, DNA 템플릿화;
	출처:아미고 / QuickGO
맞춤법
	3621
	26356
	ENSG00000153487
	ENSMUSG000045969
	Q9UK53
	Q9QXV3
	NM_198219; NM_001267728; NM_005537; NM_198217; NM_198218
NM_011919; NM_001302451; NM_001302457; NM_001302458; NM_001302459;
	NM_001302460
	NP_001254657; NP_005528; NP_937860; NP_937861; NP_937862
NP_001289380; NP_001289386; NP_001289387; NP_001289388; NP_001289389;
	NP_036049
	위키데이터
인간 보기/편집	마우스 표시/편집

성장단백질1억제제는 ING1유전자에 ^[5]^[6]^[7]의해 인체 내에서 암호화되는 단백질이다.

기능.

이 유전자는 세포 성장 억제와 세포 자멸을 유도할 수 있는 종양 억제 단백질을 암호화한다.암호화된 단백질은 종양 억제 단백질 TP53과 물리적으로 상호작용하는 핵 단백질이며 p53 신호 경로의 구성요소이다.다양한 암에서 이 유전자의 발현과 재배열 감소가 발견되어 왔다.서로 다른 Isoforms를 코드하는 여러 개의 대체 스플라이스된 전사 변종이 ^[7]보고되었다.

13번 염색체 위치

ING1은 13번 염색체의 다음 유전자 근처에 있습니다.

CARKD탄수화물인산화효소 도메인함유단백질(기능불명)
COL4A2: A2 타입 IV 콜라겐 서브유닛
RAB20: 코넥신43 밀매의 잠재적 규제자.
CARS2: 미토콘드리아 시스티에닐-tRNA 합성효소 2

상호 작용

ING1은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000153487 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000045969 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Dec 1996). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nature Genetics. 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021. S2CID 10173092.
^ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenetics and Cell Genetics. 76 (3–4): 176–8. doi:10.1159/000134539. PMID 9186514.
^ ^a ^b "Entrez Gene: ING1 inhibitor of growth family, member 1".
^ ^a ^b Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". The Journal of Biological Chemistry. 277 (33): 29832–9. doi:10.1074/jbc.M200197200. PMID 12015309.
^ Xin H, Yoon HG, Singh PB, Wong J, Qin J (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". The Journal of Biological Chemistry. 279 (10): 9539–46. doi:10.1074/jbc.M311587200. PMID 14665632.
^ ^a ^b ^c ^d ^e Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/mcb.22.3.835-848.2002. PMC 133546. PMID 11784859.
^ Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY (Sep 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Research. 62 (17): 4890–3. PMID 12208736.
^ Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature. 391 (6664): 295–8. Bibcode:1998Natur.391..295G. doi:10.1038/34675. PMID 9440695. S2CID 4429461.
^ Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science. 114 (Pt 19): 3455–62. doi:10.1242/jcs.114.19.3455. PMID 11682605.

추가 정보

Campos EI, Chin MY, Kuo WH, Li G (Oct 2004). "Biological functions of the ING family tumor suppressors". Cellular and Molecular Life Sciences. 61 (19–20): 2597–613. doi:10.1007/s00018-004-4199-4. PMID 15526165. S2CID 28889915.
Helbing CC, Veillette C, Riabowol K, Johnston RN, Garkavtsev I (Apr 1997). "A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis". Cancer Research. 57 (7): 1255–8. PMID 9102209.
Garkavtsev I, Riabowol K (Apr 1997). "Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor". Molecular and Cellular Biology. 17 (4): 2014–9. doi:10.1128/mcb.17.4.2014. PMC 232048. PMID 9121449.
Zeremski M, Horrigan SK, Grigorian IA, Westbrook CA, Gudkov AV (May 1997). "Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34". Somatic Cell and Molecular Genetics. 23 (3): 233–6. doi:10.1007/BF02721376. PMID 9330636. S2CID 24132112.
Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature. 391 (6664): 295–8. Bibcode:1998Natur.391..295G. doi:10.1038/34675. PMID 9440695. S2CID 4429461.
Shinoura N, Muramatsu Y, Nishimura M, Yoshida Y, Saito A, Yokoyama T, Furukawa T, Horii A, Hashimoto M, Asai A, Kirino T, Hamada H (Nov 1999). "Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas". Cancer Research. 59 (21): 5521–8. PMID 10554029.
Jäger D, Stockert E, Scanlan MJ, Güre AO, Jäger E, Knuth A, Old LJ, Chen YT (Dec 1999). "Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene". Cancer Research. 59 (24): 6197–204. PMID 10626813.
Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D (Mar 2000). "Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions". Genes, Chromosomes & Cancer. 27 (3): 319–22. doi:10.1002/(SICI)1098-2264(200003)27:3<319::AID-GCC13>3.0.CO;2-P. PMID 10679922.
Tokunaga E, Maehara Y, Oki E, Kitamura K, Kakeji Y, Ohno S, Sugimachi K (Apr 2000). "Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers". Cancer Letters. 152 (1): 15–22. doi:10.1016/S0304-3835(99)00434-6. PMID 10754201.
Baranova AV, Ivanov DV, Makeeva NV, Corcoran M, Nikitin EA, Borodina TA, Poltaraus AB, Glinshchikova OA, Sudarikov AB, Oscier D, Iankovskiĭ NK (2000). "[Genomic organization of the suppressor gene for tumor growth ING1]". Molekuliarnaia Biologiia. 34 (2): 263–9. PMID 10779953.
Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A (2000). "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1". Journal of Human Genetics. 45 (3): 177–81. doi:10.1007/s100380050206. PMID 10807544.
Gunduz M, Ouchida M, Fukushima K, Hanafusa H, Etani T, Nishioka S, Nishizaki K, Shimizu K (Jun 2000). "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas". Cancer Research. 60 (12): 3143–6. PMID 10866301.
Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J (Mar 2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex". The Journal of Biological Chemistry. 276 (12): 8734–9. doi:10.1074/jbc.M007664200. PMID 11118440.
Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC (Aug 2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53". Proceedings of the National Academy of Sciences of the United States of America. 98 (17): 9671–6. Bibcode:2001PNAS...98.9671N. doi:10.1073/pnas.161151798. PMC 55510. PMID 11481424.
Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science. 114 (Pt 19): 3455–62. doi:10.1242/jcs.114.19.3455. PMID 11682605.
Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. PMC 133546. PMID 11784859.
Nouman GS, Angus B, Lunec J, Crosier S, Lodge A, Anderson JJ (Feb 2002). "Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues". Hybridoma and Hybridomics. 21 (1): 1–10. doi:10.1089/15368590252917584. PMID 11991811.
Bromidge T, Lynas C (Jul 2002). "Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies". Leukemia Research. 26 (7): 631–5. doi:10.1016/S0145-2126(01)00185-0. PMID 12008079.

외부 링크

ING1+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000153487 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000045969 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8944021-5] Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Dec 1996). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nature Genetics. 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021. S2CID 10173092.

[pmid9186514-6] Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenetics and Cell Genetics. 76 (3–4): 176–8. doi:10.1159/000134539. PMID 9186514.

[entrez-7] "Entrez Gene: ING1 inhibitor of growth family, member 1".

[pmid12015309-8] Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". The Journal of Biological Chemistry. 277 (33): 29832–9. doi:10.1074/jbc.M200197200. PMID 12015309.

[pmid14665632-9] Xin H, Yoon HG, Singh PB, Wong J, Qin J (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". The Journal of Biological Chemistry. 279 (10): 9539–46. doi:10.1074/jbc.M311587200. PMID 14665632.

[pmid11784859-10] Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/mcb.22.3.835-848.2002. PMC 133546. PMID 11784859.

[pmid12208736-11] Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY (Sep 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Research. 62 (17): 4890–3. PMID 12208736.

[pmid9440695-12] Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control". Nature. 391 (6664): 295–8. Bibcode:1998Natur.391..295G. doi:10.1038/34675. PMID 9440695. S2CID 4429461.

[pmid11682605-13] Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". Journal of Cell Science. 114 (Pt 19): 3455–62. doi:10.1242/jcs.114.19.3455. PMID 11682605.

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