YY1

YY1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1UBD, 1ZNM, 4C5나
식별자
에일리어스	YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 전사인자, GADEVS
외부 ID	OMIM: 600013 MGI: 99150 HomoloGene: 2556 GeneCard: YY1
유전자 위치(인간)
크르.	14번 염색체(인간)
끝.	100,282,788 bp
유전자 위치(마우스)
크르.	12번 염색체(쥐)
끝.	108,786,074 bp
RNA발현패턴
	상단 표시 위치:
	신경절 융기; ; 내피 세포; ; 중측두회; ; 브로드만 23구역; ; 직장; ; 단구; ; 흉선; ; 상부 신경; ; 랑게르한스 섬; ; 자궁내막간질세포;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; GO:0001106 전사 코어프레서 액티비티; GO:0001105 트랜스크립션코액티베이터 액티비티; 아연 이온 결합; 금속 이온 결합; GO:0001948 단백질 결합; 사방접합DNA결합; GO:0001158 cis-조절영역 배열 특이 DNA 결합; RNA결합; 핵산 결합; SMAD 바인딩; GO:0000980 RNA중합효소II 시스조절영역배열특이적 DNA결합; GO:0001078, GO:0001214, GO:0001206 DNA결합전사억제제활성, RNA중합효소II 특이적; GO:0001131, GO:000115, GO:0001130, GO:0001204 DNA결합전사인자액티비티; 배열특이적 DNA결합; GO:0001200, GO:0001133, GO:0001201 DNA결합전사인자활성, RNA중합효소II 특이적; 히스톤탈아세틸화효소결합;
셀룰러 컴포넌트	Ino80 콤플렉스; 핵매트릭스; 핵; 핵소체; 전사조절복합체; 세포질; PcG단백질복합체;
생물학적 과정	세포 분화; DNA재조합; 전사조절, DNA템플릿화; RNA중합효소II에 의한 전사조절; 자외선에 대한 세포 반응; 유전자 발현 음성 조절; 전사, DNA 템플릿; DNA 손상 자극에 대한 세포 반응; 상동 재조합에 의한 이중 파단 수리; 정자 형성; DNA복구; 단백질탈유비퀴티네이션; 간섭체 생성의 마이너스 조절; RNA중합효소II에 의한 전사 음성 조절; RNA 국재; 전방/전방 패턴 사양; UV-C에 대한 반응; 유전자 발현 양성 조절; 프로스타글란딘F에 대한 반응; RNA중합효소II에 의한 전사의 양성 조절; 카메라형 눈의 형태 형성; 염색체 구성; 인터류킨-1에 대한 세포반응; RNA중합효소II에 의한 pri-miRNA 전사의 음성조절; 심근 세포 발달에 관여하는 세포 증식의 음성 조절;
	출처:아미고 / QuickGO
맞춤법
	7528
	22632
	ENSG00000100811
	ENSMUSG000021264
	P25490
	Q00899
	NM_003403
	NM_009537
	NP_003394
	NP_033563
	위키데이터
인간 보기/편집	마우스 표시/편집

YY1(Yin Yang ^[5]1)은 YY1 ^[6]^[7]유전자에 의해 암호화되는 인간의 전사 억제 단백질이다.

기능.

YY1은 아연 핑거 단백질의 GLI-Kruppel급에 속하는 보편적으로 분포하는 전사인자이다.단백질은 다양한 프로모터를 억제하고 활성화하는 데 관여한다.그래서 YY는 Yin-yang의 약자입니다.YY1은 프로모터를 활성화 또는 억제하기 위해 히스톤탈아세틸화효소 및 히스톤아세틸전달효소를 프로모터에 지시할 수 있으며, 따라서 YY1의 ^[8]기능상 히스톤수식을 수반한다.Y1은 이합체를 형성하고 DNA 상호작용을 촉진함으로써 인핸서-프로모터 크로마틴 루프를 촉진한다.그것의 규제 장애는 강화제-촉진제 루프와 유전자 ^[9]^[10]발현을 방해한다.

임상적 의의

YY1 이질 접합체의 삭제, missense고, 터무니 없는 돌연변이 Gabriele-DeVries 증후군, 자궁 내 성장 제한, 변수 인지 장애가 행동적 문제와 다른 congeni에게 먹이를 주고는 상염색체성 우성 archpediatrics지적 장애 특징이 있는 추형 공포증의 얼굴 특징(GADEVS)[11][12]을 일으킨다.탈놀이 malf오미션^[10]웹사이트는 임상의와 해당 개인의 ^[13]가족 간에 임상 정보를 수집 및 공유하기 위해 사용할 수 있다.

상호 작용

YY1은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000100811 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000021264 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.
^ Shi Y, Seto E, Chang LS, Shenk T (October 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. S2CID 19399858.
^ Zhu W, Lossie AC, Camper SA, Gumucio DL (April 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122. S2CID 27296553.
^ "Entrez Gene: YY1 YY1 transcription factor".
^ Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, et al. (December 2017). "YY1 Is a Structural Regulator of Enhancer-Promoter Loops". Cell. 171 (7): 1573–1588.e28. doi:10.1016/j.cell.2017.11.008. PMC 5785279. PMID 29224777.
^ ^a ^b Gabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, et al. (June 2017). "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction". American Journal of Human Genetics. 100 (6): 907–925. doi:10.1016/j.ajhg.2017.05.006. PMC 5473733. PMID 28575647.
^ "OMIM:GABRIELE-DE VRIES SYNDROME".
^ Nabais Sá, M. J.; Gabriele, M.; Testa, G.; de Vries BBA; Adam, M. P.; Ardinger, H. H.; Pagon, R. A.; Wallace, S. E.; Bean LJH; Stephens, K.; Amemiya, A. (1993). "Gabriele-de Vries Syndrome". PMID 31145572. {{cite journal}}:Cite 저널 요구 사항 journal=(도움말)
^ "YY1 – Collect information about clinic management and research projects". YY1.
^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (July 2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Molecular and Cellular Biology. 20 (14): 5096–106. doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959. PMID 10866666.
^ ^a ^b ^c Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Molecular and Cellular Biology. 21 (17): 5979–91. doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.
^ Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
^ Yang WM, Yao YL, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
^ ^a ^b Yang WM, Yao YL, Sun JM, Davie JR, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
^ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
^ Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (December 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. Bibcode:1993Sci...262.1889S. doi:10.1126/science.8266081. PMID 8266081.
^ Yeh TS, Lin YM, Hsieh RH, Tseng MJ (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". The Journal of Biological Chemistry. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000.
^ García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
^ Huang NE, Lin CH, Lin YS, Yu WC (June 2003). "Modulation of YY1 activity by SAP30". Biochemical and Biophysical Research Communications. 306 (1): 267–75. doi:10.1016/s0006-291x(03)00966-5. PMID 12788099.
^ Fu CY, Wang P, Tsai HJ (November 2017). "Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis". Nucleic Acids Research. 45 (5): 2423–2437. doi:10.1093/nar/gkw1187. PMC 5389716. PMID 27913726.

추가 정보

Thomas MJ, Seto E (August 1999). "Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?". Gene. 236 (2): 197–208. doi:10.1016/S0378-1119(99)00261-9. PMID 10452940.
Park K, Atchison ML (November 1991). "Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9804–8. Bibcode:1991PNAS...88.9804P. doi:10.1073/pnas.88.21.9804. PMC 52809. PMID 1946405.
Yang WM, Inouye CJ, Seto E (June 1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". The Journal of Biological Chemistry. 270 (25): 15187–93. doi:10.1074/jbc.270.25.15187. PMID 7541038.
Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
Zhou Q, Gedrich RW, Engel DA (July 1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". Journal of Virology. 69 (7): 4323–30. doi:10.1128/JVI.69.7.4323-4330.1995. PMC 189172. PMID 7769693.
Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (December 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. Bibcode:1993Sci...262.1889S. doi:10.1126/science.8266081. PMID 8266081.
Becker KG, Swergold GD, Ozato K, Thayer RE (October 1993). "Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element". Human Molecular Genetics. 2 (10): 1697–702. doi:10.1093/hmg/2.10.1697. PMID 8268924.
Margolis DM, Somasundaran M, Green MR (February 1994). "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology. 68 (2): 905–10. doi:10.1128/JVI.68.2.905-910.1994. PMC 236527. PMID 8289393.
Lee JS, Galvin KM, Shi Y (July 1993). "Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1". Proceedings of the National Academy of Sciences of the United States of America. 90 (13): 6145–9. Bibcode:1993PNAS...90.6145L. doi:10.1073/pnas.90.13.6145. PMC 46884. PMID 8327494.
Yang WM, Inouye C, Zeng Y, Bearss D, Seto E (November 1996). "Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12845–50. Bibcode:1996PNAS...9312845Y. doi:10.1073/pnas.93.23.12845. PMC 24008. PMID 8917507.
Houbaviy HB, Usheva A, Shenk T, Burley SK (November 1996). "Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator". Proceedings of the National Academy of Sciences of the United States of America. 93 (24): 13577–82. Bibcode:1996PNAS...9313577H. doi:10.1073/pnas.93.24.13577. PMC 19349. PMID 8942976.
Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
Cole EG, Gaston K (September 1997). "A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors". Nucleic Acids Research. 25 (18): 3705–11. doi:10.1093/nar/25.18.3705. PMC 146936. PMID 9278494.
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
Romerio F, Gabriel MN, Margolis DM (December 1997). "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology. 71 (12): 9375–82. doi:10.1128/JVI.71.12.9375-9382.1997. PMC 230241. PMID 9371597.
McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein GS (March 1998). "Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking". Journal of Cellular Biochemistry. 68 (4): 500–10. doi:10.1002/(SICI)1097-4644(19980315)68:4<500::AID-JCB9>3.0.CO;2-U. PMID 9493912. S2CID 34077497.
Viles JH, Patel SU, Mitchell JB, Moody CM, Justice DE, Uppenbrink J, Doyle PM, Harris CJ, Sadler PJ, Thornton JM (June 1998). "Design, synthesis and structure of a zinc finger with an artificial beta-turn". Journal of Molecular Biology. 279 (4): 973–86. doi:10.1006/jmbi.1998.1764. PMID 9642075.
Yao YL, Dupont BR, Ghosh S, Fang Y, Leach RJ, Seto E (August 1998). "Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1". Nucleic Acids Research. 26 (16): 3776–83. doi:10.1093/nar/26.16.3776. PMC 147783. PMID 9685495.

외부 링크

팩터북 YY1
PDB for UniProt: P25490(전사억제단백질 YY1)에서 PDBe-KB에 제공되는 모든 구조 정보의 개요.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000100811 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000021264 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.

[pmid1655281-6] Shi Y, Seto E, Chang LS, Shenk T (October 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. S2CID 19399858.

[pmid7912122-7] Zhu W, Lossie AC, Camper SA, Gumucio DL (April 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122. S2CID 27296553.

[8] "Entrez Gene: YY1 YY1 transcription factor".

[9] Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, et al. (December 2017). "YY1 Is a Structural Regulator of Enhancer-Promoter Loops". Cell. 171 (7): 1573–1588.e28. doi:10.1016/j.cell.2017.11.008. PMC 5785279. PMID 29224777.

[YY1_Haploinsufficiency_Causes_an_Intellectual_Disability_Syndrome_Featuring_Transcriptional_and_Chromatin_Dysfunction.-10] Gabriele M, Vulto-van Silfhout AT, Germain PL, Vitriolo A, Kumar R, Douglas E, et al. (June 2017). "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction". American Journal of Human Genetics. 100 (6): 907–925. doi:10.1016/j.ajhg.2017.05.006. PMC 5473733. PMID 28575647.

[11] "OMIM:GABRIELE-DE VRIES SYNDROME".

[12] Nabais Sá, M. J.; Gabriele, M.; Testa, G.; de Vries BBA; Adam, M. P.; Ardinger, H. H.; Pagon, R. A.; Wallace, S. E.; Bean LJH; Stephens, K.; Amemiya, A. (1993). "Gabriele-de Vries Syndrome". PMID 31145572. {{cite journal}}:Cite 저널 요구 사항 journal=(도움말)

[13] "YY1 – Collect information about clinic management and research projects". YY1.

[pmid10866666-14] Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (July 2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Molecular and Cellular Biology. 20 (14): 5096–106. doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959. PMID 10866666.

[pmid11486036-15] Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Molecular and Cellular Biology. 21 (17): 5979–91. doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.

[pmid7758944-16] Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.

[pmid11532945-17] Yang WM, Yao YL, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.

[pmid9346952-18] Yang WM, Yao YL, Sun JM, Davie JR, Seto E (October 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.

[pmid9016636-19] Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (February 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.

[pmid8266081-20] Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (December 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. Bibcode:1993Sci...262.1889S. doi:10.1126/science.8266081. PMID 8266081.

[pmid12913000-21] Yeh TS, Lin YM, Hsieh RH, Tseng MJ (October 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". The Journal of Biological Chemistry. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000.

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