전사 팩터 2 활성화
Activating transcription factor 2
ATF2라고도 알려진 활성화 전사인자 2는 인간에서 ATF2 [5]유전자에 의해 암호화되는 단백질이다.
기능.
이 유전자는 DNA 결합 단백질의 류신 지퍼 계열의 구성원인 전사 인자를 암호화합니다.이 단백질은 팔중미 회문인 cAMP-responsive element(CRE; cAMP-responsive element)에 결합합니다.단백질은 c-Jun과 호모디머 또는 헤테로디머를 형성한다.단백질은 또한 히스톤 H2B와 H4를 시험관내에서 특이적으로 아세틸화하는 히스톤 아세틸전달효소(HAT)이다. 따라서 염색질 성분에 대한 직접적인 영향에 의해 전사를 활성화하는 배열 특이적 인자의 클래스를 나타낼 수 있다.추가적인 전사 변형이 확인되었지만 생물학적 타당성은 [5]확인되지 않았다.
atf2 유전자는 인간 염색체 2q32에 [6]위치한다.ATF-2 단백질은 505개의 아미노산을 가지고 있습니다.쥐를 대상으로 한 연구는 신경계와 [7]골격 발달에서 ATF-2의 역할을 나타낸다.ATF-2는 일반적으로 스트레스 활성화 단백질 키나아제 p38 및 JNK에 [8]수렴하는 신호에 반응하여 활성화된다. ATF-2 인산화 반응은 종양 프로모터 포르볼 에스테르에 의한 세포 치료에 대한 반응으로 [9]입증되었다.
포유류의 피부종양의 [10][11]성장과 진행에 ATF-2의 비정상적인 활성화가 수반되는 여러 연구들이 있다.ATF-2는 돌연변이 Ras[12] 단백질에 의한 발암을 매개하여 상피세포의 공격적인 암 표현형의 유지를 규제할 수 있다.
ATF2는 또한 이중 가닥 [13]절단 시 ATM에 의해 C 말단(마우스에서는 세린 472 및 480, 인간에서는 세린 490 및 498)에서 인산화되는 것으로 나타났다.이 두 가지 세린의 돌연변이를 가진 생쥐는 방사선에 민감하고 p53 녹아웃 배경에서 종양 발생이 더 쉽다.
상호 작용
전사인자 2를 활성화하는 것은
- 씨준 [14][15][16]씨
- 카제인 키나아제2,[17] 알파1,
- CREB 결합 [18]단백질
- CSNK2A2,[17]
- JDP2,[19]
- MAPK14,[20][21][22]
- MAPK8,[20][21][22][23]
- 반신불수 호몰로그 3에 반대하는 엄마들[24]
- NCOA6,[25]
- RUVBL2,[26]
- UBE2I[27]
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레퍼런스
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- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027104 - 앙상블, 2017년 5월
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외부 링크
- UCSC Genome Browser의 인간 ATF2 게놈 위치 및 ATF2 유전자 세부 정보 페이지.
추가 정보
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외부 링크
- PDBe-KB는 인간 순환 AMP 의존 전사인자 ATF-2에 대한 PDB에서 사용 가능한 모든 구조 정보의 개요를 제공합니다.
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