PBX2
PBX2| PBX2 | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 에일리어스 | PBX2, G17, HOX12, PBX2MHC, PBX 홈박스2 | ||||||||||||||||||||||||
| 외부 ID | OMIM: 176311 MGI: 1341793 HomoloGene: 48115 GeneCard: PBX2 | ||||||||||||||||||||||||
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| 맞춤법 | |||||||||||||||||||||||||
| 종. | 인간 | 마우스 | |||||||||||||||||||||||
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| 앙상블 |
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| 유니프로트 | |||||||||||||||||||||||||
| RefSeq(mRNA) | |||||||||||||||||||||||||
| RefSeq(단백질) | |||||||||||||||||||||||||
| 장소(UCSC) | Chr 6: 32.18 ~32.19 Mb | Chr 17: 34.81 ~34.82 Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키데이터 | |||||||||||||||||||||||||
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B세포 백혈병 전사인자 2는 PBX2 [5][6]유전자에 의해 인체 내에서 암호화되는 단백질이다.
기능.
이 유전자는 TALE/PBX 호메오박스 패밀리의 보편적으로 발현되는 구성원을 암호화합니다.급성 B세포 백혈병에서 t(1;19) 전위에 관여하는 호메오박스 유전자와의 유사성으로 확인되었다.이 단백질은 TLX1 프로모터에 결합하는 전사 활성제입니다.이 유전자는 [6]6번 염색체의 주요 조직적합성 복합체(MHC) 안에 있다.
상호 작용
PBX2는 HOXA9와 [7]상호 작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c ENSG00000237344, ENSG00000236353, ENSG00000232005, ENSG00000225987, ENSG00000206315, ENSG00000204304 GRCh38: Ensembl 릴리즈 89: ENSG00000224952, ENSG343400004
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000034673 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Sep 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.
- ^ a b "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2".
- ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/mcb.19.4.3051. PMC 84099. PMID 10082572.
추가 정보
- Monica K, Galili N, Nourse J, Saltman D, Cleary ML (Dec 1991). "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Molecular and Cellular Biology. 11 (12): 6149–57. doi:10.1128/mcb.11.12.6149. PMC 361792. PMID 1682799.
- Aguado B, Campbell RD (Feb 1995). "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein". Genomics. 25 (3): 650–9. doi:10.1016/0888-7543(95)80007-9. PMID 7759099.
- Lu Q, Wright DD, Kamps MP (Jun 1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Molecular and Cellular Biology. 14 (6): 3938–48. doi:10.1128/mcb.14.6.3938. PMC 358760. PMID 7910944.
- Katsanis N, Fitzgibbon J, Fisher EM (Jul 1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci". Genomics. 35 (1): 101–8. doi:10.1006/geno.1996.0328. PMID 8661110.
- Berthelsen J, Zappavigna V, Mavilio F, Blasi F (Mar 1998). "Prep1, a novel functional partner of Pbx proteins". The EMBO Journal. 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMC 1170490. PMID 9482739.
- Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/MCB.19.4.3051. PMC 84099. PMID 10082572.
- Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T (Jul 2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Experimental Hematology. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
- Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
- Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T (Jun 2003). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood. 101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID 12609849.
- Longobardi E, Blasi F (Oct 2003). "Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation". The Journal of Biological Chemistry. 278 (40): 39235–41. doi:10.1074/jbc.M304704200. PMID 12871956.
- Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (Dec 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
외부 링크
- PBX2+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)
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