NFE2

NFE2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2KZ5
식별자
에일리어스	NFE2, NF-E2, p45, 핵인자, 적혈구 2
외부 ID	OMIM: 601490 MGI: 97308 HomoloGene: 4491 GeneCard: NFE2
유전자 위치(인간)
크르.	12번 염색체(인간)
끝.	54,104,015 bp
유전자 위치(마우스)
크르.	15번 염색체(쥐)
끝.	103,440,830 bp
RNA발현패턴
	상단 표시 위치:
	피; ; 단구; ; 결석골; ; 골수; ; 골수 세포; ; 비장; ; 오른쪽 폐; ; 좌폐 상엽; ; 치주 섬유; ; 부록;
	상단 표시 위치:
	피; ; 비장; ; 노른자낭; ; 골수; ; 대퇴골체; ; 요도; ; 남성 요도; ; 작은 구멍; ; 모룰라; ; 복벽;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 N말단결합; 전사공활성화제활성; 전사 시스 조절 영역 결합; 단백질 결합; WW 도메인 바인딩; DNA결합전사인자활성; 배열특이적 DNA결합; DNA결합; 시스조절영역배열특이DNA결합; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	세포질; PML 본체; 핵; 핵소체; 단백질-DNA복합체;
생물학적 과정	지혈; 전사조절, DNA템플릿화; 혈액 응고; 혈액 순환; 전사, DNA 템플릿; 다세포 생물 발달; 전사의 양성 조절, DNA 템플릿화; 뉴클레오솜 분해; RNA중합효소II에 의한 전사조절; 거핵구 분화 조절;
	출처:아미고 / QuickGO
맞춤법
	4778
	18022
	ENSG00000123405
	ENSMUSG000058794
	문제 16621
	Q07279
NM_001136023; NM_001261461; NM_006163; NM_001400365; NM_001400372;
	NM_001400373
NM_008685; NM_001302338; NM_001302339; NM_001302340; NM_001302341;
	NM_001302343; NM_001400376
	NP_001129495; NP_001248390; NP_006154
NP_001289267; NP_001289268; NP_001289269; NP_001289270; NP_001289272;
	NP_032711; NP_001387305
	위키데이터
인간 보기/편집	마우스 표시/편집

전사인자 NF-E2 45kDa 서브유닛은 NFE2 ^[5]^[6]유전자에 의해 인간에서 암호화되는 단백질이다.

그것은 거핵구 ^[7]생성에 관여한다.

상호 작용

NFE2는 CREB 결합 ^[8]단백질과 상호작용하는 것으로 나타났다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000123405 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000058794 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol. 13 (9): 5604–12. doi:10.1128/mcb.13.9.5604. PMC 360284. PMID 8355703.
^ "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".
^ Gasiorek JJ, Blank V (2015). "Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells". Cellular and Molecular Life Sciences. 72 (12): 2323–2335. doi:10.1007/s00018-015-1866-6. PMID 25721735. S2CID 18020988.
^ Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.

추가 정보

Strauss EC, Andrews NC, Higgs DR, Orkin SH (1992). "In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction". Mol. Cell. Biol. 12 (5): 2135–42. doi:10.1128/MCB.12.5.2135. PMC 364385. PMID 1569944.
Pischedda C, Cocco S, Melis A, Marini MG, Kan YW, Cao A, Moi P (1995). "Isolation of a differentially regulated splicing isoform of human NF-E2". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3511–5. Bibcode:1995PNAS...92.3511P. doi:10.1073/pnas.92.8.3511. PMC 42197. PMID 7724591.
Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (1995). "Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development". Cell. 81 (5): 695–704. doi:10.1016/0092-8674(95)90531-6. PMID 7774011. S2CID 14195541.
Igarashi K, Kataoka K, Itoh K, Hayashi N, Nishizawa M, Yamamoto M (1994). "Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins". Nature. 367 (6463): 568–72. Bibcode:1994Natur.367..568I. doi:10.1038/367568a0. PMID 8107826. S2CID 4339431.
Chan JY, Han XL, Kan YW (1994). "Isolation of cDNA encoding the human NF-E2 protein". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11366–70. doi:10.1073/pnas.90.23.11366. PMC 47983. PMID 8248255.
Toki T, Itoh J, Kitazawa J, Arai K, Hatakeyama K, Akasaka J, Igarashi K, Nomura N, Yokoyama M, Yamamoto M, Ito E (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif". Oncogene. 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.
Blank V, Kim MJ, Andrews NC (1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression". Blood. 89 (11): 3925–35. doi:10.1182/blood.V89.11.3925. PMID 9166829.
Gavva NR, Gavva R, Ermekova K, Sudol M, Shen CJ (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II". J. Biol. Chem. 272 (39): 24105–8. doi:10.1074/jbc.272.39.24105. PMID 9305852.
Mosser EA, Kasanov JD, Forsberg EC, Kay BK, Ney PA, Bresnick EH (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains". Biochemistry. 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456.
Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.
Gavva NR, Wen SC, Daftari P, Moniwa M, Yang WM, Yang-Feng LP, Seto E, Davie JR, Shen CK (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor". Genomics. 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372.
Boulanger L, Sabatino DE, Wong EY, Cline AP, Garrett LJ, Garbarz M, Dhermy D, Bodine DM, Gallagher PG (2003). "Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins". J. Biol. Chem. 277 (44): 41563–70. doi:10.1074/jbc.M208184200. PMID 12196550.
Marini MG, Asunis I, Chan K, Chan JY, Kan YW, Porcu L, Cao A, Moi P (2003). "Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation". Blood Cells Mol. Dis. 29 (2): 145–58. doi:10.1006/bcmd.2002.0550. PMID 12490281.
Onishi Y, Kiyama R (2003). "Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling". J. Biol. Chem. 278 (10): 8163–71. doi:10.1074/jbc.M209612200. PMID 12509425.
Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. PMID 12805554. S2CID 36715183.
Chuen CK, Li K, Yang M, Fok TF, Li CK, Chui CM, Yuen PM (2004). "Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells". J. Lab. Clin. Med. 143 (2): 75–88. doi:10.1016/j.lab.2003.09.006. PMID 14966463.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

외부 링크

NFE2+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)
팩터북 NF-E2

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

인간 염색체 12번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000123405 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000058794 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8355703-5] Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol. 13 (9): 5604–12. doi:10.1128/mcb.13.9.5604. PMC 360284. PMID 8355703.

[entrez-6] "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".

[7] Gasiorek JJ, Blank V (2015). "Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells". Cellular and Molecular Life Sciences. 72 (12): 2323–2335. doi:10.1007/s00018-015-1866-6. PMID 25721735. S2CID 18020988.

[pmid11154691-8] Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.

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NFE2

네임스페이스

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상호 작용

레퍼런스

추가 정보

외부 링크