GTF2H1

GTF2H1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1PFJ, 2DII, 2RNR, 2RUK, 2RVB
식별자
에일리어스	GTF2H1, BTF2, P62, TFB1, TFIIH, 일반전사인자 IIH 서브유닛 1
외부 ID	OMIM : 18972 MGI : 1277216 HomoloGene : 3885 GenCard : GTF2H1
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	18,367,045 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	46,473,224 bp
RNA발현패턴
	상단 표시 위치:
	아킬레스건; ; 뇌량; ; 자궁내막; ; 흉선; ; 단구; ; 랑게르한스 섬; ; 평활근 조직; ; 담낭; ; 경골 신경; ; 복부 피부;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질인산화효소활성; DNA에 작용하는 ATP 의존성 활성; 크로마틴 결합; GO:0001948 단백질 결합; RNA중합효소IICTD헵타펩타이드반복인산화효소활성;
셀룰러 컴포넌트	핵소체; 전사인자 TFIIH홀로 착화체; 핵; GO:0000441 전사율 TFIIH 코어 복합체;
생물학적 과정	RNA중합효소I전사의종료; 사이클린 의존성 단백질 세린/트레오닌인산화효소 활성 조절; 전사조절, DNA템플릿화; RNA중합효소I 프로모터로부터의 전사 개시; RNA중합효소II 프로모터로부터의 전사 신장; 7-메틸구아노신mRNA캡핑; RNA중합효소II에 의한 전사; 전사, DNA 템플릿; DNA 손상 자극에 대한 세포 반응; 글로벌 게놈 뉴클레오티드 절제 복구; 전사가능뉴클레오티드절제수복원; RNA중합효소II 프로모터로부터의 전사 개시; 뉴클레오티드 절제 복구, DNA 절개; DNA복구; RNA중합효소II에 의한 전사의 양성 조절; 뉴클레오티드 절제 복구, 전절제 복합 안정화; 뉴클레오티드 절제 회복; 뉴클레오티드 절제 복구, DNA 절개, 5'-to 병변; 뉴클레오티드-절제복구, 전절제복합체조립체; RNA중합효소I에 의한 전사; RNA중합효소IIC말단도메인의인산화; 뉴클레오티드절제복구, DNA쌍꺼풀림; 뉴클레오티드 절제 복구, DNA 절개, 3'-to 병변; RNA중합효소I 프로모터로부터의 전사 신장;
	출처:아미고 / QuickGO
맞춤법
	2965
	14884
	ENSG00000110768; ENSG00000288114
	ENSMUSG00000006599
	P32780
	Q9DBA9
	NM_001142307; NM_005316
	NM_001291075; NM_008186; NM_001360075; NM_001360076
	NP_001135779; NP_005307
	NP_001278004; NP_032212; NP_001347004; NP_001347005
	위키데이터
인간 보기/편집	마우스 표시/편집

일반전사인자 IIH 서브유닛1은 GTF2H1 ^[5]^[6]^[7]유전자에 의해 인간에서 암호화되는 단백질이다.

상호 작용

GTF2H1은 다음과 상호작용하는 것으로 나타났습니다.

「」를 참조해 주세요.

전사 계수 II H

레퍼런스

^ ^a ^b ^c ENSG00000288114 GRCh38: 앙상블 릴리즈 89: ENSG00000110768, ENSG00000288114 - Ensembl, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000006599 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM (October 1992). "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science. 257 (5075): 1392–5. Bibcode:1992Sci...257.1392F. doi:10.1126/science.1529339. PMID 1529339.
^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
^ "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa".
^ ^a ^b ^c Rossignol M, Kolb-Cheynel I, Egly JM (April 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708.
^ Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature. 374 (6519): 283–7. Bibcode:1995Natur.374..283S. doi:10.1038/374283a0. PMID 7533895. S2CID 4282418.
^ Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393.
^ Vandel L, Kouzarides T (August 1999). "Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase". EMBO J. 18 (15): 4280–91. doi:10.1093/emboj/18.15.4280. PMC 1171504. PMID 10428966.
^ Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D (April 1994). "Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II". Nature. 368 (6473): 769–72. Bibcode:1994Natur.368..769D. doi:10.1038/368769a0. PMID 8152490. S2CID 4363484.
^ Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly JM, Ali S (July 2000). "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7". Mol. Cell. 6 (1): 127–37. doi:10.1016/s1097-2765(00)00014-9. PMID 10949034.
^ Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
^ Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
^ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (July 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.
^ Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (March 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.

추가 정보

Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447-9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature. 374 (6519): 283–7. Bibcode:1995Natur.374..283S. doi:10.1038/374283a0. PMID 7533895. S2CID 4282418.
Tong X, Drapkin R, Reinberg D, Kieff E (1995). "The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3259–63. Bibcode:1995PNAS...92.3259T. doi:10.1073/pnas.92.8.3259. PMC 42145. PMID 7724549.
Fantes JA, Oghene K, Boyle S, Danes S, Fletcher JM, Bruford EA, Williamson K, Seawright A, Schedl A, Hanson I (1995). "A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1". Genomics. 25 (2): 447–61. doi:10.1016/0888-7543(95)80045-N. PMID 7789978.
Xiao H, Pearson A, Coulombe B, Truant R, Zhang S, Regier JL, Triezenberg SJ, Reinberg D, Flores O, Ingles CJ (1994). "Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53". Mol. Cell. Biol. 14 (10): 7013–24. doi:10.1128/mcb.14.10.7013. PMC 359231. PMID 7935417.
Schaeffer L, Moncollin V, Roy R, Staub A, Mezzina M, Sarasin A, Weeda G, Hoeijmakers JH, Egly JM (1994). "The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor". EMBO J. 13 (10): 2388–92. doi:10.1002/j.1460-2075.1994.tb06522.x. PMC 395103. PMID 8194528.
Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC 231191. PMID 8628270.
Iyer N, Reagan MS, Wu KJ, Canagarajah B, Friedberg EC (1996). "Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein". Biochemistry. 35 (7): 2157–67. doi:10.1021/bi9524124. PMID 8652557.
Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. Bibcode:1996PNAS...93.6482R. doi:10.1073/pnas.93.13.6482. PMC 39049. PMID 8692841.
Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. Bibcode:1996PNAS...93.6488D. doi:10.1073/pnas.93.13.6488. PMC 39050. PMID 8692842.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID 8934526. S2CID 4278432.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.
Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.
Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC 232028. PMID 9121429.
Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708.
García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription". EMBO J. 16 (10): 2836–50. doi:10.1093/emboj/16.10.2836. PMC 1169892. PMID 9184228.

외부 링크

GTF2H1+단백질+인간(미국 국립의학도서관 의학 과목 표제(MeSH))
PDB for UniProt: P32780(일반 전사인자 IIH 서브유닛 1)에서 PDBe-KB에서 사용할 수 있는 모든 구조 정보의 개요.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] ENSG00000288114 GRCh38: 앙상블 릴리즈 89: ENSG00000110768, ENSG00000288114 - Ensembl, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000006599 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1529339-5] Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM (October 1992). "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science. 257 (5075): 1392–5. Bibcode:1992Sci...257.1392F. doi:10.1126/science.1529339. PMID 1529339.

[pmid8162052-6] Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.

[entrez-7] "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa".

[pmid9130708-8] Rossignol M, Kolb-Cheynel I, Egly JM (April 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708.

[pmid7533895-9] Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature. 374 (6519): 283–7. Bibcode:1995Natur.374..283S. doi:10.1038/374283a0. PMID 7533895. S2CID 4282418.

[pmid8521393-10] Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393.

[pmid10428966-11] Vandel L, Kouzarides T (August 1999). "Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase". EMBO J. 18 (15): 4280–91. doi:10.1093/emboj/18.15.4280. PMC 1171504. PMID 10428966.

[pmid8152490-12] Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D (April 1994). "Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II". Nature. 368 (6473): 769–72. Bibcode:1994Natur.368..769D. doi:10.1038/368769a0. PMID 8152490. S2CID 4363484.

[pmid10949034-13] Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly JM, Ali S (July 2000). "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7". Mol. Cell. 6 (1): 127–37. doi:10.1016/s1097-2765(00)00014-9. PMID 10949034.

[pmid9765293-14] Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.

[pmid9305922-15] Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.

[pmid15220921-16] Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (July 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.

[pmid9118947-17] Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (March 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.

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GTF2H1

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