IFI16
IFI16
γ-인터페론 유도성 단백질 Ifi-16(Ifi-16)은 간섭성 골수 분화 전사 활성제로도 알려져 있으며, 인체에서 IFI16 [5][6][7]유전자에 의해 암호화되는 단백질이다.
기능.
이 유전자는 사이토카인의 HIN-200(아미노산 200회 반복으로 조혈인터페론 유도핵항원) 계열의 멤버를 암호화한다.암호화된 단백질은 DNA 결합, 전사 조절 및 단백질-단백질 상호작용에 관련된 도메인을 포함합니다.단백질은 핵소체와 핵소체에 국재하며 p53,[8] 망막아종-1 및 BRCA1과 [9]상호작용한다.p53 기능을 조절하고 Ras/Raf 시그널링 [7]경로에서 세포 성장을 억제합니다.IFI16은 바이러스 감염 세포의 특징인 세포[10] 내 DNA를 감지하는 데 역할을 하는 것으로 나타났으며 프로그램된 세포 [11][12]사멸의 매우 염증적인 형태인 파엽토시스(pyroptosis)에 의한 HIV 감염 도우미 CD4 T 세포의 죽음과도 관련이 있다.최근에는 IFI16이 세포외에서 방출된 후 TLR4 결합 시 염증을 유발하여 [13]DAMP 역할을 하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000163565 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000073491 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Trapani JA, Browne KA, Dawson MJ, Ramsay RG, Eddy RL, Show TB, White PC, Dupont B (Oct 1992). "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". Immunogenetics. 36 (6): 369–76. doi:10.1007/bf00218044. PMID 1526658. S2CID 1196925.
- ^ Trapani JA, Dawson M, Apostolidis VA, Browne KA (Dec 1994). "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization". Immunogenetics. 40 (6): 415–24. doi:10.1007/bf00177824. PMID 7959953. S2CID 2602156.
- ^ a b "Entrez Gene: IFI16 interferon, gamma-inducible protein 16".
- ^ Ouchi, Mutsuko; Ouchi, Toru (2008-01-01). "Role of IFI16 in DNA damage and checkpoint". Frontiers in Bioscience. 13 (13): 236–239. doi:10.2741/2673. ISSN 1093-9946. PMID 17981541.
- ^ Dutta, Dipanjan; Dutta, Sujoy; Veettil, Mohanan Valiya; Roy, Arunava; Ansari, Mairaj Ahmed; Iqbal, Jawed; Chikoti, Leela; Kumar, Binod; Johnson, Karen E. (2015-06-01). "BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses". PLOS Pathogens. 11 (6): e1005030. doi:10.1371/journal.ppat.1005030. ISSN 1553-7374. PMC 4487893. PMID 26121674.
- ^ Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG (2010). "IFI16 is an innate immune sensor for intracellular DNA". Nat. Immunol. 11 (11): 997–1004. doi:10.1038/ni.1932. PMC 3142795. PMID 20890285.
- ^ Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC (2014). "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV". Science. 343 (6169): 428–32. Bibcode:2014Sci...343..428M. doi:10.1126/science.1243640. PMC 3976200. PMID 24356113.
- ^ Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC (2014). "Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection". Nature. 505 (7484): 509–14. Bibcode:2014Natur.505..509D. doi:10.1038/nature12940. PMC 4047036. PMID 24356306.
- ^ Iannucci A, Caneparo V, Raviola S, Debernardi I, Colangelo D, et al. (20) 세포외 IFI16에 의해 유발되는 톨라이크 수용체 4 매개 염증을 리포다당 결합에 의해 증강시킨다.PLOS 병원체 16(9) : e1008811.https://doi.org/10.1371/journal.ppat.1008811
추가 정보
- Dawson MJ, Trapani JA (1995). "IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines". J. Cell. Biochem. 57 (1): 39–51. doi:10.1002/jcb.240570106. PMID 7536752. S2CID 3007802.
- Dawson MJ, Trapani JA, Briggs RC, et al. (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression". Immunogenetics. 41 (1): 40–3. doi:10.1007/BF00188431. PMID 7806273. S2CID 12788123.
- Johnstone RW, Kerry JA, Trapani JA (1998). "The human interferon-inducible protein, IFI 16, is a repressor of transcription". J. Biol. Chem. 273 (27): 17172–7. doi:10.1074/jbc.273.27.17172. PMID 9642285.
- Johnstone RW, Kershaw MH, Trapani JA (1998). "Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing". Biochemistry. 37 (34): 11924–31. doi:10.1021/bi981069a. PMID 9718316.
- Dawson MJ, Elwood NJ, Johnstone RW, Trapani JA (1998). "The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations". J. Leukoc. Biol. 64 (4): 546–54. doi:10.1002/jlb.64.4.546. PMID 9766636. S2CID 40241172.
- Briggs LJ, Johnstone RW, Elliot RM, et al. (2001). "Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16". Biochem. J. 353 (Pt 1): 69–77. doi:10.1042/0264-6021:3530069. PMC 1221544. PMID 11115400.
- Johnstone RW, Wei W, Greenway A, Trapani JA (2001). "Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16". Oncogene. 19 (52): 6033–42. doi:10.1038/sj.onc.1204005. PMID 11146555.
- Gariglio M, Azzimonti B, Pagano M, et al. (2003). "Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells" (PDF). J. Interferon Cytokine Res. 22 (7): 815–21. doi:10.1089/107999002320271413. hdl:2318/39497. PMID 12184920.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
- Clarke CJ, Apostolidis V, Hii LL, et al. (2003). "Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16". J. Cell. Biochem. 89 (1): 80–93. doi:10.1002/jcb.10475. PMID 12682910. S2CID 32678644.
- Xin H, Curry J, Johnstone RW, et al. (2003). "Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence". Oncogene. 22 (31): 4831–40. doi:10.1038/sj.onc.1206754. PMID 12894224.
- Kwak JC, Ongusaha PP, Ouchi T, Lee SW (2003). "IFI16 as a negative regulator in the regulation of p53 and p21(Waf1)". J. Biol. Chem. 278 (42): 40899–904. doi:10.1074/jbc.M308012200. PMID 12925527.
- Aglipay JA, Lee SW, Okada S, et al. (2004). "A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway". Oncogene. 22 (55): 8931–8. doi:10.1038/sj.onc.1207057. PMID 14654789.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Raffaella R, Gioia D, De Andrea M, et al. (2004). "The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells". Exp. Cell Res. 293 (2): 331–45. doi:10.1016/j.yexcr.2003.10.014. hdl:2318/42932. PMID 14729471.
- Fujiuchi N, Aglipay JA, Ohtsuka T, et al. (2004). "Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation". J. Biol. Chem. 279 (19): 20339–44. doi:10.1074/jbc.M400344200. PMID 14990579.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
외부 링크
- IFI16+단백질+미국국립의학도서관 의학 과목 제목(MeSH)
PDB 갤러리 | |
|---|---|
|
이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.
