GRLF1
GRLF1
글루코콜티코이드 수용체 DNA결합인자 1은 GRLF1 [5][6]유전자에 의해 인체 내에서 암호화되는 단백질이다.
기능.
글루코콜티코이드 수용체 유전자(hGR 유전자)의 프로모터 영역과 관련된 인간 글루코콜티코이드 수용체 DNA 결합 인자는 글루코콜티코이드 수용체 전사의 억제제이다.cDNA 배열에서 추론된 아미노산 배열은 아연 손가락의 특징인 세 개의 배열 모티브와 모든 류신 대신 1개의 시스테인이 발견되는 류신 지퍼를 암시하는 하나의 모티브의 존재를 보여준다.GRLF1은 야생형 hGR 유전자 발현의 상동성 하향 조절을 강화한다.생화학적 분석에 따르면 GRLF1 상호작용은 배열 특이적이며 GRLF1의 전사효과는 특정 배열 모티브와의 상호작용을 통해 조절된다.발현 수준은 글루코콜티코이드에 [6]의해 조절된다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000160007 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000058230 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ LeClerc S, Palaniswami R, Xie BX, Govindan MV (Sep 1991). "Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression". The Journal of Biological Chemistry. 266 (26): 17333–40. doi:10.1016/S0021-9258(19)47378-X. PMID 1894621.
- ^ a b "Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1".
추가 정보
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- Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo". The Journal of Biological Chemistry. 282 (33): 23910–8. doi:10.1074/jbc.M702169200. PMID 17562701.
외부 링크
- GRLF1+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)
- 셀 이행 게이트웨이에 링크가 있는 GRLF1 정보
