MEF2B

BORCS8-MEF2B
사용 가능한 구조
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	1N6J, 1TQE
식별자
에일리어스	BORCS8-MEF2B, LOC729991-MEF2B, MEF2B, MEF2B, BORCS8-MEF2B 리드스루, RSRFR2B
외부 ID	GeneCards: BORCS8-MEF2B
유전자 존재론
분자 함수	DNA결합전사인자활성; RNA중합효소II 시스조절영역배열특이적 DNA결합; DNA결합; DNA결합전사활성화제, RNA중합효소II 특이적; 히스톤탈아세틸화효소결합; 단백질 이량화 활성; RNA중합효소II전사조절영역배열특이적DNA결합; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵; 전사조절복합체;
생물학적 과정	근육 기관의 발달; 전사조절, DNA템플릿화; 전사, DNA 템플릿; RNA중합효소II에 의한 전사; RNA중합효소II에 의한 전사의 양성 조절;
	출처:아미고 / QuickGO
맞춤법
	4207
	없음
	ENSG000064489
	없음
	Q02080
	없음
	NM_005919
	없음
	NP_001139257; NP_001354211; NP_005910.1
	없음
	위키데이터
인간 보기/편집

근세포증강제결합인자 2B(MEF2B)는 MEF2A, MEF2C 및 MEF2D를 ^[2]^[3]포함한 MEF2 유전자군의 전사인자 부분이다.단, MEF2B는 척추동물의 ^[4]단백질 코드 홀리데이 접합인식단백질 C-말단(HJURP_C) 영역이 없기 때문에 MEF2 유전자의 다른 3가지와 거리가 있다.

기능들

MEF2 유전자 패밀리는 근육 특이적 유전자 활성화와 발달 ^[4]^[5]중 유지로 발현된다.MEF2B mRNA는 골격,^[6] 평활, 뇌 및 심장 근육에 존재한다.MEF2B는 평활근 미오신 헤비체인(SMHC) 유전자 조절에 직접 관여한다.MEF2B의 과발현은 ^[6]SMHC 프로모터가 프로모터의 A/T가 풍부한 요소에 결합할 때 평활근에서 SMHC 프로모터를 활성화한다.

상호 작용

MEF2B는 CABIN1과 ^[7]^[8]상호 작용하는 것으로 나타났습니다.

임상 관련성

이 유전자의 반복적인 돌연변이는 확산성 B세포 림프종의 ^[9]경우와 연관되어 왔다.MEF2B는 그 돌연변이 형태에서 확산대형 B세포 림프종(DLBCL)^[10]에서 원유전자 BCL6 발현을 규제 해제시킬 수 있다.MEF2B의 돌연변이는 코어프레서 CAB의 중단으로 인해 전사 활성을 향상시킨다.IN1 또는 억제 시그널링 이벤트에 ^[10]둔감한 유전자를 발생시킨다.

「」를 참조해 주세요.

메프2

레퍼런스

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krenács, Dóra; Borbényi, Zita; Bedekovics, Judit; Méhes, Gábor; Bagdi, Enikő; Krenács, László (2015-09-01). "Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas". Virchows Archiv. 467 (3): 345–355. doi:10.1007/s00428-015-1796-6. ISSN 1432-2307. PMID 26089142. S2CID 25535467.
^ Rodríguez, Andrés I.; Csányi, Gábor; Ranayhossaini, Daniel J.; Feck, Douglas M.; Blose, Kory J.; Assatourian, Lillian; Vorp, David A.; Pagano, Patrick J. (2015-02-01). "MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 35 (2): 430–438. doi:10.1161/ATVBAHA.114.304936. ISSN 1524-4636. PMC 4409426. PMID 25550204.
^ ^a ^b Wu, Wenwu; de Folter, Stefan; Shen, Xia; Zhang, Wenqian; Tao, Shiheng (2011-01-01). "Vertebrate paralogous MEF2 genes: origin, conservation, and evolution". PLOS ONE. 6 (3): e17334. Bibcode:2011PLoSO...617334W. doi:10.1371/journal.pone.0017334. ISSN 1932-6203. PMC 3048864. PMID 21394201.
^ Buchberger, A.; Arnold, H. H. (1999-06-01). "The MADS domain containing transcription factor cMef2a is expressed in heart and skeletal muscle during embryonic chick development". Development Genes and Evolution. 209 (6): 376–381. doi:10.1007/s004270050267. ISSN 0949-944X. PMID 10370120. S2CID 2819535.
^ ^a ^b Katoh, Y.; Molkentin, J. D.; Dave, V.; Olson, E. N.; Periasamy, M. (1998-01-16). "MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression". The Journal of Biological Chemistry. 273 (3): 1511–1518. doi:10.1074/jbc.273.3.1511. ISSN 0021-9258. PMID 9430690.
^ Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. Bibcode:2003Natur.422..730H. doi:10.1038/nature01555. PMID 12700764. S2CID 4430658.
^ Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
^ Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, et al. (Aug 2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma" (PDF). Nature. 476 (7360): 298–303. Bibcode:2011Natur.476..298M. doi:10.1038/nature10351. PMC 3210554. PMID 21796119.
^ ^a ^b Ying, Carol Y.; Dominguez-Sola, David; Fabi, Melissa; Lorenz, Ivo C.; Hussein, Shafinaz; Bansal, Mukesh; Califano, Andrea; Pasqualucci, Laura; Basso, Katia (2013-10-01). "MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma". Nature Immunology. 14 (10): 1084–1092. doi:10.1038/ni.2688. ISSN 1529-2916. PMC 3954820. PMID 23974956.

추가 정보

Yu YT, Breitbart RE, Smoot LB, Lee Y, Mahdavi V, Nadal-Ginard B (Sep 1992). "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors". Genes & Development. 6 (9): 1783–98. doi:10.1101/gad.6.9.1783. PMID 1516833.
Pollock R, Treisman R (Dec 1991). "Human SRF-related proteins: DNA-binding properties and potential regulatory targets". Genes & Development. 5 (12A): 2327–41. doi:10.1101/gad.5.12a.2327. PMID 1748287.
Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL (Oct 1995). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics. 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763.
Katoh Y, Molkentin JD, Dave V, Olson EN, Periasamy M (Jan 1998). "MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression". The Journal of Biological Chemistry. 273 (3): 1511–8. doi:10.1074/jbc.273.3.1511. PMID 9430690.
Iida K, Hidaka K, Takeuchi M, Nakayama M, Yutani C, Mukai T, Morisaki T (Jan 1999). "Expression of MEF2 genes during human cardiac development". The Tohoku Journal of Experimental Medicine. 187 (1): 15–23. doi:10.1620/tjem.187.15. PMID 10458488.
Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.
Li M, Linseman DA, Allen MP, Meintzer MK, Wang X, Laessig T, Wierman ME, Heidenreich KA (Sep 2001). "Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons". The Journal of Neuroscience. 21 (17): 6544–52. doi:10.1523/JNEUROSCI.21-17-06544.2001. PMC 6763101. PMID 11517243.
Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. Bibcode:2003Natur.422..730H. doi:10.1038/nature01555. PMID 12700764. S2CID 4430658.
Konig S, Hinard V, Arnaudeau S, Holzer N, Potter G, Bader CR, Bernheim L (Jul 2004). "Membrane hyperpolarization triggers myogenin and myocyte enhancer factor-2 expression during human myoblast differentiation". The Journal of Biological Chemistry. 279 (27): 28187–96. doi:10.1074/jbc.M313932200. PMID 15084602.
Han A, He J, Wu Y, Liu JO, Chen L (Jan 2005). "Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2". Journal of Molecular Biology. 345 (1): 91–102. doi:10.1016/j.jmb.2004.10.033. PMID 15567413.
Gong X, Tsai SW, Yan B, Rubin LP (2006). "Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression". BMC Molecular Biology. 7: 7. doi:10.1186/1471-2199-7-7. PMC 1526748. PMID 16504037.

외부 링크

MEF2B+단백질+미국국립의학도서관 의학 과목 제목(MeSH)

이 단백질 관련 기사는 스텁입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] Krenács, Dóra; Borbényi, Zita; Bedekovics, Judit; Méhes, Gábor; Bagdi, Enikő; Krenács, László (2015-09-01). "Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas". Virchows Archiv. 467 (3): 345–355. doi:10.1007/s00428-015-1796-6. ISSN 1432-2307. PMID 26089142. S2CID 25535467.

[3] Rodríguez, Andrés I.; Csányi, Gábor; Ranayhossaini, Daniel J.; Feck, Douglas M.; Blose, Kory J.; Assatourian, Lillian; Vorp, David A.; Pagano, Patrick J. (2015-02-01). "MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 35 (2): 430–438. doi:10.1161/ATVBAHA.114.304936. ISSN 1524-4636. PMC 4409426. PMID 25550204.

[:0-4] Wu, Wenwu; de Folter, Stefan; Shen, Xia; Zhang, Wenqian; Tao, Shiheng (2011-01-01). "Vertebrate paralogous MEF2 genes: origin, conservation, and evolution". PLOS ONE. 6 (3): e17334. Bibcode:2011PLoSO...617334W. doi:10.1371/journal.pone.0017334. ISSN 1932-6203. PMC 3048864. PMID 21394201.

[5] Buchberger, A.; Arnold, H. H. (1999-06-01). "The MADS domain containing transcription factor cMef2a is expressed in heart and skeletal muscle during embryonic chick development". Development Genes and Evolution. 209 (6): 376–381. doi:10.1007/s004270050267. ISSN 0949-944X. PMID 10370120. S2CID 2819535.

[:1-6] Katoh, Y.; Molkentin, J. D.; Dave, V.; Olson, E. N.; Periasamy, M. (1998-01-16). "MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression". The Journal of Biological Chemistry. 273 (3): 1511–1518. doi:10.1074/jbc.273.3.1511. ISSN 0021-9258. PMID 9430690.

[pmid12700764-7] Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L (Apr 2003). "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2". Nature. 422 (6933): 730–4. Bibcode:2003Natur.422..730H. doi:10.1038/nature01555. PMID 12700764. S2CID 4430658.

[pmid10531067-8] Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–3. doi:10.1126/science.286.5440.790. PMID 10531067.

[MorinMendez-Lago2011-9] Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, et al. (Aug 2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma" (PDF). Nature. 476 (7360): 298–303. Bibcode:2011Natur.476..298M. doi:10.1038/nature10351. PMC 3210554. PMID 21796119.

[:2-10] Ying, Carol Y.; Dominguez-Sola, David; Fabi, Melissa; Lorenz, Ivo C.; Hussein, Shafinaz; Bansal, Mukesh; Califano, Andrea; Pasqualucci, Laura; Basso, Katia (2013-10-01). "MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma". Nature Immunology. 14 (10): 1084–1092. doi:10.1038/ni.2688. ISSN 1529-2916. PMC 3954820. PMID 23974956.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

Search

MEF2B

네임스페이스

더

목차

기능들

상호 작용

임상 관련성

「」를 참조해 주세요.

레퍼런스

추가 정보

외부 링크

Search

MEF2B

기능들

상호 작용

임상 관련성

「 」를 참조해 주세요.

레퍼런스

추가 정보

외부 링크

「」를 참조해 주세요.