PIT1은 포유류의 뇌하수체 발달과 호르몬 발현을 담당하는 뇌하수체 특이 전사 인자이며 포유류의 발달을 조절하는 POU 계열의 전사 인자 중 하나이다.POU 계열은 처음 확인된 3개 구성원이 포유류의 PIT1과 OCT1(MIM 164)과 C. elegans의 Unc-86(Herr et al., 1988)이었기 때문에 그렇게 명명되었다.PIT1은 성장호르몬(GH; MIM 139250)과 프로락틴(PRL; MIM 176760)을 코드하는 유전자에 대한 고친화성 DNA 결합에 필요한 POU 특이적 및 POU-homeo라는 2개의 단백질 도메인을 포함한다.PIT1은 또한 프로락틴 및 갑상선 자극 호르몬 베타 서브유닛(TSHB; MIM 188540)을 티로트로핀 방출 호르몬(TRH; MIM 257120)과 순환 AMP에 [5]의해 코드하는 유전자의 조절에도 중요하다.
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