호모 사피엔스 종의 단백질 코드 유전자
비히스톤염색체단백질 HMG-14 는 인체 에서 HMG1 [5] [6] [7] 단백질 이다.
기능. 염색체 단백질 HMG14와 그 근접 아날로그 HMG17(MIM 163910)은 핵염색체 DNA의 안쪽에 결합하여 DNA와 히스톤 옥타머 간의 상호작용을 잠재적으로 변화시킨다. 두 단백질은 독특한 크로마틴 [8] 그들의 유비쿼터스 분포와 상대적 풍부함, 그리고 HMG14 단백질 패밀리의 DNA 결합 도메인의 높은 진화적 보존은 그들이 중요한 세포 [7]
상호 작용 HMGN1은 YWHAZ 와 [9] 것 으로 나타났습니다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000205581 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000040681 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Landsman D, Srikantha T, Westermann R, Bustin M (Dec 1986). "Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family" . The Journal of Biological Chemistry . 261 (34): 16082–6. doi :10.1016/S0021-9258(18)66680-3 PMID 3782107 . ^ Landsman D, McBride OW, Soares N, Crippa MP, Srikantha T, Bustin M (Feb 1989). "Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family" . The Journal of Biological Chemistry . 264 (6): 3421–7. doi :10.1016/S0021-9258(18)94084-6 PMID 2563381 . ^ a b "Entrez Gene: HMGN1 high-mobility group nucleosome binding domain 1" .^ Martínez de Paz A, Ausió J (2016). "HMGNs: The enhancer charmers". BioEssays . 38 (3): 226–31. doi :10.1002/bies.201500157 . PMID 26709929 . S2CID 24768724 . ^ Prymakowska-Bosak M, Hock R, Catez F, Lim JH, Birger Y, Shirakawa H, Lee K, Bustin M (Oct 2002). "Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins" . Molecular and Cellular Biology . 22 (19): 6809–19. doi :10.1128/MCB.22.19.6809-6819.2002 . PMC 134047 PMID 12215538 .
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