호모 사피엔스 종의 단백질 코드 유전자
KLF11 [5] [6] [7] 단백질 인 크루펠 유사인자 11.
KLF11은 Krüppel-like factor(KLF; 크뤼펠 유사인자 ) 패밀리의 중배엽 유도 아연 핑거 전사 인자입니다. 세포 성장을 억제하고 아포토시스를 유발하는 엡실론 및 감마글로빈 유전자 촉진제의 SP1과 같은 GC가 풍부한 염기서열에 결합한다. 유전자 조절에서는 세포의 염증과 분화에 관여하여 초기 배아 발달에 필수적인 요소가 됩니다. 이 전사 인자는 콜레스테롤, 프로스타글란딘, 신경전달물질, 지방, 그리고 설탕 대사와 관련된 유전자의 촉진제, 특히 췌장 베타 세포 기능에 결합합니다. KLF11의 결함은 성인 2형 당뇨병과 청년 7형 성숙기 당뇨병의 원인 이 되는 포도당 대사, 인슐린 전사, 인슐린 처리 및 인슐린 분비에 영향을 미친다. 이러한 유형의 당뇨병은 KLF11이 췌장섬 베타세포의 공동억제물질 과 상호작용하여 발생한다. KLF11은 최근 세포외 기질 유전자의 발현을 조절한 이후 자궁내막증 에 관여하는 것으로 나타났다. 세포외 기질 유전자의 부재는 조직에 의한 섬유화 반응을 더 많이 만들었다. 이것은 「녹아웃」모델을 작성함으로써 증명되었습니다. 실험 결과 KLF11의 부재는 자궁내막 병변의 성장을 막고 병적 흉터를 억제하는 섬유화 양이 많은 것으로 나타났다.
[8] [9] [10]
상호 작용 KLF11은 SIN3A 와 [11] [12] 것 으로 나타났습니다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000172059 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000020653 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R (Oct 1998). "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth" . The Journal of Biological Chemistry . 273 (40): 25929–36. doi :10.1074/jbc.273.40.25929 PMID 9748269 . ^ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". 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외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY
