MEF2D

MEF2D
식별자
에일리어스	MEF2D, 근구증강인자2D
외부 ID	OMIM: 600663 MGI: 99533 HomoloGene: 4327 GenCard: MEF2D
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	156,500,779 bp
유전자 위치(마우스)
크르.	3번 염색체(마우스)
끝.	88,079,393 bp
RNA발현패턴
	상단 표시 위치:
	위근; ; 슬와 동맥; ; 복정맥; ; 상부 신경; ; 위점막; ; 자궁경관; ; 우관상 동맥; ; 좌심실; ; 내피 세포; ; 좌측 자궁관;
	상단 표시 위치:
	장피질; ; 상전두회; ; 족저근; ; 장척근신장; ; 발목 관절; ; 이복근; ; 골격근 조직; ; 상완; ; 상완 삼두근; ; 안외근;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; 단백질 이량화 활성; 단백질 호모다이머화; DNA결합전사인자활성; DNA결합전사활성화제, RNA중합효소II 특이적; 히스톤탈아세틸화효소결합; RNA중합효소II 시스조절영역배열특이적 DNA결합; 단백질 결합; 단백질 헤테로다이머화 활성; 효소결합; RNA중합효소II전사조절영역배열특이적DNA결합; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	세포질; 세포막내소기관; 핵소체; 핵;
생물학적 과정	세포 분화; 전사조절, DNA템플릿화; 연골세포분화; 성인의 심장 발달; 근육 기관의 발달; 연골내 골화; RNA중합효소II에 의한 전사; 전사, DNA 템플릿; 신경계의 발달; 다세포 생물 발달; 전사의 양성 조절, DNA 템플릿화; 골아세포분화; 골격근세포분화; RNA중합효소II에 의한 전사의 양성 조절; 아포토시스 과정; 혈관관련 평활근세포증식의 양성조절;
	출처:아미고 / QuickGO
맞춤법
	4209
	17261
	ENSG00000116604
	ENSMUSG00000001419
	Q14814
	질문 63943
	NM_001271629; NM_005920
	NM_133665; NM_001310587; NM_001310593
	NP_001258558; NP_005911
	NP_001297516; NP_001297522; NP_598426
	위키데이터
인간 보기/편집	마우스 표시/편집

근구특이적 증강인자 2D는 MEF2D ^[5]^[6]유전자에 의해 인간에서 암호화되는 단백질이다.

상호 작용

MEF2D는 다음과 상호작용하는 것으로 나타났습니다.

「」를 참조해 주세요.

메프2

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000116604 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001419 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–1106. doi:10.1242/dev.118.4.1095. PMID 8269842.
^ "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)".
^ ^a ^b Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.
^ Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–793. doi:10.1126/science.286.5440.790. PMID 10531067.
^ Youn HD, Grozinger CM, Liu JO (Jul 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry. 275 (29): 22563–22567. doi:10.1074/jbc.C000304200. PMID 10825153.
^ Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771–4777. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
^ Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry. 271 (40): 24927–24933. doi:10.1074/jbc.271.40.24927. PMID 8798771.
^ Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–4331. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.
^ Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/s0161-5890(02)00055-x. PMID 12213324.
^ Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research. 29 (13): 2836–2842. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030.

추가 정보

Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL (Oct 1995). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics. 29 (3): 704–711. doi:10.1006/geno.1995.9007. PMID 8575763.
Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry. 271 (40): 24927–24933. doi:10.1074/jbc.271.40.24927. PMID 8798771.
Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771–4777. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.
Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J (Jan 1999). "Regulation of the MEF2 family of transcription factors by p38". Molecular and Cellular Biology. 19 (1): 21–30. doi:10.1128/mcb.19.1.21. PMC 83862. PMID 9858528.
Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (Nov 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Molecular and Cellular Biology. 19 (11): 7816–7827. doi:10.1128/mcb.19.11.7816. PMC 84849. PMID 10523670.
Lu J, McKinsey TA, Nicol RL, Olson EN (Apr 2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases". Proceedings of the National Academy of Sciences of the United States of America. 97 (8): 4070–4075. Bibcode:2000PNAS...97.4070L. doi:10.1073/pnas.080064097. PMC 18151. PMID 10737771.
Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD (Jun 2000). "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family". The Journal of Biological Chemistry. 275 (24): 18534–18540. doi:10.1074/jbc.M001573200. PMID 10849446.
Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–4331. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.
Slepak TI, Webster KA, Zang J, Prentice H, O'Dowd A, Hicks MN, Bishopric NH (Mar 2001). "Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D". The Journal of Biological Chemistry. 276 (10): 7575–7585. doi:10.1074/jbc.M004625200. PMID 11096067.
Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research. 29 (13): 2836–2842. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030.
Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA (Mar 2002). "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 99 (6): 3974–3979. Bibcode:2002PNAS...99.3974O. doi:10.1073/pnas.022036399. PMC 122633. PMID 11904443.
Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/S0161-5890(02)00055-X. PMID 12213324.
Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA (Oct 2003). "Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival". The Journal of Biological Chemistry. 278 (42): 41472–41481. doi:10.1074/jbc.M307245200. PMID 12896970.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Grégoire S, Yang XJ (Mar 2005). "Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors". Molecular and Cellular Biology. 25 (6): 2273–2287. doi:10.1128/MCB.25.6.2273-2287.2005. PMC 1061617. PMID 15743823.
Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP (May 2005). "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia". Leukemia. 19 (5): 806–813. doi:10.1038/sj.leu.2403684. PMID 15744350.

외부 링크

MEF2D+단백질+미국 국립의학도서관 의학 과목 제목(MeSH)

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000116604 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001419 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8269842-5] Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage". Development. 118 (4): 1095–1106. doi:10.1242/dev.118.4.1095. PMID 8269842.

[entrez-6] "Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)".

[pmid10933397-7] Youn HD, Liu JO (Jul 2000). "Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2". Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.

[pmid10531067-8] Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2". Science. 286 (5440): 790–793. doi:10.1126/science.286.5440.790. PMID 10531067.

[pmid10825153-9] Youn HD, Grozinger CM, Liu JO (Jul 2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". The Journal of Biological Chemistry. 275 (29): 22563–22567. doi:10.1074/jbc.C000304200. PMID 10825153.

[pmid9753748-10] Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Research. 26 (20): 4771–4777. doi:10.1093/nar/26.20.4771. PMC 147902. PMID 9753748.

[pmid8798771-11] Ornatsky OI, McDermott JC (Oct 1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". The Journal of Biological Chemistry. 271 (40): 24927–24933. doi:10.1074/jbc.271.40.24927. PMID 8798771.

[pmid10944115-12] Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–4331. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.

[pmid12213324-13] Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter". Molecular Immunology. 39 (1–2): 25–30. doi:10.1016/s0161-5890(02)00055-x. PMID 12213324.

[pmid11433030-14] Choi SJ, Park SY, Han TH (Jul 2001). "14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation". Nucleic Acids Research. 29 (13): 2836–2842. doi:10.1093/nar/29.13.2836. PMC 55772. PMID 11433030.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

Search

MEF2D

네임스페이스

더

목차

상호 작용

「」를 참조해 주세요.

레퍼런스

추가 정보

외부 링크

Search

MEF2D

상호 작용

「 」를 참조해 주세요.

레퍼런스

추가 정보

외부 링크

「」를 참조해 주세요.