플리1

플리1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1FLI, 1X66, 2YTU, 5E8G, 5E8I
식별자
에일리어스	FLI1, EWSR2, SIC-1, Fli-1 proto-oncogen, ETS 전사인자, BDPLT21, FLI-1
외부 ID	OMIM: 193067 MGI: 95554 HomoloGene: 55624 GeneCard: FLI1
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	128,813,267 bp
유전자 위치(마우스)
크르.	9번 염색체(쥐)
끝.	32,454,194 bp
RNA발현패턴
	상단 표시 위치:
	단구; ; 피; ; 비장; ; 골수 세포; ; 결석골; ; 부록; ; 림프절; ; 오른쪽 폐; ; 좌폐 상엽; ; 내장 흉막;
	상단 표시 위치:
	진피; ; 비장; ; 좌폐엽; ; 피; ; 복벽; ; 대퇴골체; ; 늑간근; ; 흉선; ; 피하 지방 조직; ; 방실 밸브;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 결합; RNA중합효소II 시스조절영역배열특이적 DNA결합; 크로마틴 결합; 배열특이적 DNA결합; DNA결합전사인자활성; DNA결합; DNA결합전사활성화제, RNA중합효소II 특이적; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵; 세포; 핵체;
생물학적 과정	거핵구 발달; RNA중합효소II에 의한 전사의 양성 조절; RNA중합효소II에 의한 전사; 지혈; 전사조절, DNA템플릿화; RNA중합효소II에 의한 전사조절; 세포 분화; 동물 기관 형태 형성; 혈액 순환; 전사, DNA 템플릿; 전사의 양성 조절, DNA 템플릿화;
	출처:아미고 / QuickGO
맞춤법
	2313
	14247
	ENSG00000151702
	ENSMUSG000016087
	Q01543
	P26323
	NM_001167681; NM_001271010; NM_001271012; NM_002017
	NM_008026
	NP_001161153; NP_001257939; NP_001257941; NP_002008; NP_001161153.1
	NP_032052
	위키데이터
인간 보기/편집	마우스 표시/편집

친구 백혈병 통합 1 전사인자(FLI1)는 전사인자 ERGB로도 알려져 있으며, 인간에서 FLI1 유전자에 의해 암호화되는 단백질로, 원종 ^[5]^[6]^[7]유전자이다.

기능.

Fli-1은 Friend Murine 백혈병 바이러스(F-MuLV)에 의해 유도된 에리트로우케미아스에서 처음 확인된 ETS 전사인자 패밀리의 일원이다.F-MuLV 유도성 적혈구균 90%에서 레트로바이러스 삽입 돌연변이 유발에 의해 Fli-1이 활성화된다.적아세포에서 플리-1의 구성 활성화는 에포/Epo-R 신호 전달 경로의 극적인 변화를 초래하여 적아세포 분화를 차단하고, Ras 경로를 활성화하며, 대규모 에포 비의존적 증식을 초래한다.이러한 결과는 적아세포의 Fli-1 과발현이 Epo에 대한 반응을 변화시키고 말단 분화와 관련된 시그널링 이벤트를 ^{[citation needed]}증식으로 전환함으로써 비정상적인 증식을 유발함을 시사한다.

임상적 의의

Friend 적혈구 백혈병 외에 fli-1 궤적에서의 프로바이러스 통합은 10A1, Graphi 및 Cas-Br-E 바이러스에 의해 유도되는 백혈병에서도 일어난다.Fli-1 이상발현 또한 인간의 염색체 이상과 관련이 있다.소아 유잉 육종에서 염색체 전위는 EWSR1(EWS라고도 함)의 5' 트랜스활성화 도메인과 Fli-1의 3' Ets 도메인의 융합을 생성한다.결과적으로 발생하는 융접온단백질인 EWS/Fli-1은 비정상적인 전사 활성제로 ^[8]작용한다.강력한 변환 기능을 갖추고 있습니다.EWS/Fli-1은 엔나이서 유사 GGAA 마이크로 ^[9]위성과의 상호작용을 통해 임상적으로 중요한 유전자를 유도할 수 있다.급성 골수성 백혈병(AML)과 같은 인간 백혈병 발병에서 Fli-1의 중요성은 단백질-단백질 상호작용을 통해 Fli-1과 상호작용하는 Tel 전사 인자와 관련된 전위 연구에서 입증되었다.최근 연구에서 면역 조직 ^{[citation needed]}화학을 이용한 여러 양성 및 악성 종양에서 Fli-1 발현 수치가 높다는 것이 입증되었다.

파리-트루소 증후군과의 연관성이 ^[10]제안되었다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000151702 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000016087 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baud V, Lipinski M, Rassart E, Poliquin L, Bergeron D (September 1991). "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24". Genomics. 11 (1): 223–4. doi:10.1016/0888-7543(91)90124-W. PMID 1765382.
^ Prasad DD, Rao VN, Reddy ES (October 1992). "Structure and expression of human Fli-1 gene". Cancer Research. 52 (20): 5833–7. PMID 1394211.
^ Rao VN, Ohno T, Prasad DD, Bhattacharya G, Reddy ES (August 1993). "Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein". Oncogene. 8 (8): 2167–73. PMID 8336942.
^ Ohno T, Rao VN, Reddy ES (December 1993). "EWS/Fli-1 chimeric protein is a transcriptional activator". Cancer Research. 53 (24): 5859–63. PMID 7503813.
^ Musa, Julian; Cidre-Aranaz, Florencia; Aynaud, Marie-Ming; Orth, Martin; Mirabeau, Olivier; Varon, Mor; Grossetete, Sandrine; Surdez, Didier; et al. (2018-12-27). "Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancer". bioRxiv: 506659. doi:10.1101/506659.
^ Raslova H, Komura E, Le Couédic JP, Larbret F, Debili N, Feunteun J, et al. (July 2004). "FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia". The Journal of Clinical Investigation. 114 (1): 77–84. doi:10.1172/JCI21197. PMC 437972. PMID 15232614.

추가 정보

Ben-David Y, Giddens EB, Bernstein A (February 1990). "Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus". Proceedings of the National Academy of Sciences of the United States of America. 87 (4): 1332–6. Bibcode:1990PNAS...87.1332B. doi:10.1073/pnas.87.4.1332. PMC 53469. PMID 2304901.
Ben-David Y, Giddens EB, Letwin K, Bernstein A (June 1991). "Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1". Genes & Development. 5 (6): 908–18. doi:10.1101/gad.5.6.908. PMID 2044959.
Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, et al. (September 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature. 359 (6391): 162–5. Bibcode:1992Natur.359..162D. doi:10.1038/359162a0. PMID 1522903. S2CID 4331584.
Pereira R, Quang CT, Lesault I, Dolznig H, Beug H, Ghysdael J (February 1999). "FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts". Oncogene. 18 (8): 1597–608. doi:10.1038/sj.onc.1202534. PMID 10102630.
Tamir A, Howard J, Higgins RR, Li YJ, Berger L, Zacksenhaus E, et al. (June 1999). "Fli-1, an Ets-related transcription factor, regulates erythropoietin-induced erythroid proliferation and differentiation: evidence for direct transcriptional repression of the Rb gene during differentiation". Molecular and Cellular Biology. 19 (6): 4452–64. doi:10.1128/mcb.19.6.4452. PMC 104404. PMID 10330185.
Zochodne B, Truong AH, Stetler K, Higgins RR, Howard J, Dumont D, et al. (May 2000). "Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia". Oncogene. 19 (19): 2296–304. doi:10.1038/sj.onc.1203590. PMID 10822380.
Starck J, Doubeikovski A, Sarrazin S, Gonnet C, Rao G, Skoultchi A, et al. (January 1999). "Spi-1/PU.1 is a positive regulator of the Fli-1 gene involved in inhibition of erythroid differentiation in friend erythroleukemic cell lines". Molecular and Cellular Biology. 19 (1): 121–35. doi:10.1128/mcb.19.1.121. PMC 83871. PMID 9858537.
Truong AH, Ben-David Y (December 2000). "The role of Fli-1 in normal cell function and malignant transformation". Oncogene. 19 (55): 6482–9. doi:10.1038/sj.onc.1204042. PMID 11175364.
Ohno T, Rao VN, Reddy ES (December 1993). "EWS/Fli-1 chimeric protein is a transcriptional activator". Cancer Research. 53 (24): 5859–63. PMID 7503813.
Dhulipala PD, Lee L, Rao VN, Reddy ES (September 1998). "Fli-1b is generated by usage of differential splicing and alternative promoter". Oncogene. 17 (9): 1149–57. doi:10.1038/sj.onc.1202030. PMID 9764825.
Rao VN, Ohno T, Prasad DD, Bhattacharya G, Reddy ES (August 1993). "Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein". Oncogene. 8 (8): 2167–73. PMID 8336942.
Ban J, Siligan C, Kreppel M, Aryee D, Kovar H (2007). "EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage". Advances in Experimental Medicine and Biology. 587: 41–52. doi:10.1007/978-1-4020-5133-3_4. ISBN 978-1-4020-4966-8. PMID 17163154.
Prasad DD, Rao VN, Reddy ES (October 1992). "Structure and expression of human Fli-1 gene". Cancer Research. 52 (20): 5833–7. PMID 1394211.
Watson DK, Smyth FE, Thompson DM, Cheng JQ, Testa JR, Papas TS, Seth A (October 1992). "The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors". Cell Growth & Differentiation. 3 (10): 705–13. PMID 1445800.
Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, et al. (September 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature. 359 (6391): 162–5. Bibcode:1992Natur.359..162D. doi:10.1038/359162a0. PMID 1522903. S2CID 4331584.
Baud V, Lipinski M, Rassart E, Poliquin L, Bergeron D (September 1991). "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24". Genomics. 11 (1): 223–4. doi:10.1016/0888-7543(91)90124-W. PMID 1765382.
Bergeron D, Poliquin L, Kozak CA, Rassart E (January 1991). "Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas". Journal of Virology. 65 (1): 7–15. doi:10.1128/JVI.65.1.7-15.1991. PMC 240483. PMID 1845910.
Bhagirath T, Abe S, Nojima T, Yoshida MC (June 1995). "Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma". Genes, Chromosomes & Cancer. 13 (2): 126–32. doi:10.1002/gcc.2870130209. PMID 7542907. S2CID 36929552.
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May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB, et al. (December 1993). "The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1". Molecular and Cellular Biology. 13 (12): 7393–8. doi:10.1128/mcb.13.12.7393. PMC 364810. PMID 8246959.
Hromas R, May W, Denny C, Raskind W, Moore J, Maki RA, et al. (February 1993). "Human FLI-1 localizes to chromosome 11Q24 and has an aberrant transcript in neuroepithelioma". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1172 (1–2): 155–8. doi:10.1016/0167-4781(93)90283-J. PMID 8439553.
Magnaghi-Jaulin L, Masutani H, Robin P, Lipinski M, Harel-Bellan A (March 1996). "SRE elements are binding sites for the fusion protein EWS-FLI-1". Nucleic Acids Research. 24 (6): 1052–8. doi:10.1093/nar/24.6.1052. PMC 145748. PMID 8604338.
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Knoop LL, Baker SJ (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". The Journal of Biological Chemistry. 275 (32): 24865–71. doi:10.1074/jbc.M001661200. PMID 10827180.
Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M, Watson DK (August 2000). "Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor". Molecular and Cellular Biology. 20 (15): 5643–52. doi:10.1128/MCB.20.15.5643-5652.2000. PMC 86032. PMID 10891501.
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외부 링크

FLI1+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000151702 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000016087 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1765382-5] Baud V, Lipinski M, Rassart E, Poliquin L, Bergeron D (September 1991). "The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24". Genomics. 11 (1): 223–4. doi:10.1016/0888-7543(91)90124-W. PMID 1765382.

[pmid1394211-6] Prasad DD, Rao VN, Reddy ES (October 1992). "Structure and expression of human Fli-1 gene". Cancer Research. 52 (20): 5833–7. PMID 1394211.

[pmid8336942-7] Rao VN, Ohno T, Prasad DD, Bhattacharya G, Reddy ES (August 1993). "Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein". Oncogene. 8 (8): 2167–73. PMID 8336942.

[pmid7503813-8] Ohno T, Rao VN, Reddy ES (December 1993). "EWS/Fli-1 chimeric protein is a transcriptional activator". Cancer Research. 53 (24): 5859–63. PMID 7503813.

[9] Musa, Julian; Cidre-Aranaz, Florencia; Aynaud, Marie-Ming; Orth, Martin; Mirabeau, Olivier; Varon, Mor; Grossetete, Sandrine; Surdez, Didier; et al. (2018-12-27). "Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancer". bioRxiv: 506659. doi:10.1101/506659.

[pmid15232614-10] Raslova H, Komura E, Le Couédic JP, Larbret F, Debili N, Feunteun J, et al. (July 2004). "FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia". The Journal of Clinical Investigation. 114 (1): 77–84. doi:10.1172/JCI21197. PMC 437972. PMID 15232614.

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플리1

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기능.

임상적 의의

레퍼런스

추가 정보

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