픽스
NFIX
핵인자 1 X형은 인간의 NFIX [5][6][7]유전자에 의해 암호화되는 단백질이다.NFIX의 스플라이스 변종인 NFI-X3는 성세포에서 [8]Glial fibrary satid protein과 YKL-40을 조절한다.
상호 작용
Nfix는 SKI[9] 단백질과 상호작용하는 것으로 나타났으며 AP-1과도 상호작용하는 것으로 알려져 있다.[8] NFI-X3는 [8]STAT3과 상호작용하는 것으로 나타났다.
배아세포에서 Nfix는 INSC의 전사를 촉진함으로써 중간 전구세포(IPC) 생성을 조절하는 것으로 나타났다.INSER는 방사상 글리아 세포를 IPC로 쉽게 분할할 수 있도록 스핀들 방향을 조절합니다. Nfix는 글리아 자손의 중간 자손으로의 확약에 필요한 것으로 생각됩니다.돌연변이는 요골 글리아의 과잉 생산, IPC의 손상 및 부적절한 시간적 발달, 뉴런의 과소 생산을 야기할 수 있습니다.[10]
성인 발달에서 신경 분화의 타이밍은 해마의 지속적인 성장과 적절한 기억 기능을 촉진하기 위해 Nfix에 의해 조절된다.Nfix는 세포들이 치상회 내에서 뉴런 발달을 위해 헌신하도록 하기 위해 올리고덴드로사이트 발현을 억제할 수 있다.중간 전구 세포는 신경아세포를 생성하기 위해 분열할 수 있다.Nfix null IPC에 의해 생성된 뉴런은 성숙하지 않고, 보통 죽으며, 인지 [11]장애의 원인이 될 수 있습니다.
Nfix는 미오스타틴과 상호작용하며 미오스타틴 발현 변조를 통해 근육 재생의 시간적 진행을 조절한다.Nfix는 또한 느리게 꼬이는 근육 표현형을 [12][13]억제한다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000008441 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000001911 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Seisenberger C, Winnacker EL, Scherthan H (Aug 1993). "Localisation of the human nuclear factor I/X (NFI/X) gene to chromosome 19p13 and detection of five other related loci at 1p21-22, 1q42-43, 5q15, 11p13 and 20q13 by FISH". Hum Genet. 91 (6): 535–537. doi:10.1007/bf00205076. PMID 8340106. S2CID 22365562.
- ^ Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
- ^ "Entrez Gene: NFIX nuclear factor I/X (CCAAT-binding transcription factor)".
- ^ a b c Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T (November 2011). "A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40". J. Biol. Chem. 286 (46): 39893–39903. doi:10.1074/jbc.M111.257451. PMC 3220556. PMID 21953450.
- ^ Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (October 1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–3903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.
- ^ Harris, Lachlan; Zalucki, Oressia; Gobius, Ilan; McDonald, Hannah; Osinki, Jason; Harvey, Tracey J.; Essebier, Alexandra; Vidovic, Diana; Gladwyn-Ng, Ivan; Burne, Thomas H.; Heng, Julian I.; Richards, Linda J.; Gronostajski, Richard M.; Piper, Michael (2016-10-28). "Transcriptional Regulation of Intermediate Progenitor Cell Generation during Hippocampal Development". Development. 143 (24): 4620–4630. doi:10.1242/dev.140681. PMC 5201028. PMID 27965439.
- ^ Harris, Lachlan; Zalucki, Oressia; Clément, Olivier; Fraser, James; Matuzelski, Elise; Oishi, Sabrina; Harvey, Tracey J.; Burne, Thomas H. J.; Heng, Julian I.; Richards, Linda J.; Gronostajski, Richard M.; Piper, Michael (2018-02-07). "Neurogenic Differentation by Hippocampal Neural Stem and Progenitor Cells is Biased by NFIX Expression". Development. 145 (3): 1–12. doi:10.1242/dev.155689. PMID 29437824.
- ^ Omairi, Saleh; Matsakas, Antonios; Degens, Hans; Kretz, Oliver; Hansson, Kenth-Arne; Solbrå, Andreas Våvang; Bruusgaard, Jo C.; Joch, Barbara; Sartori, Roberta; Giallourou, Natasa; Mitchell, Robert; Collins-Hooper, Henry; Foster, Keith; Pasternack, Arja; Ritvos, Olli; Sandri, Marco; Narkar, Vihang; Swann, Jonathan R.; Huber, Tobias B.; Patel, Ketan (5 August 2016). Cossu, Giulio (ed.). "Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres eLife". eLife. 5: e16940. doi:10.7554/eLife.16940. PMC 4975572. PMID 27494364.
- ^ Rossi, Giuliana; Antonini, Stefania; Bonfanti, Chiara; Monteverde, Stefania; Vezzali, Chiara; Tajbakhsh, Shahragim; Cossu, Giulio; Messina, Graziella (8 March 2016). "Nfix Regulates Temporal Progression of Muscle Regeneration through Modulation of Myostatin Expression". Cell Reports. 14 (9): 2238–2249. doi:10.1016/j.celrep.2016.02.014. PMC 4793149. PMID 26923583.
추가 정보
- Apt D, Liu Y, Bernard HU (1994). "Cloning and functional analysis of spliced isoforms of human nuclear factor I-X: interference with transcriptional activation by NFI/CTF in a cell-type specific manner". Nucleic Acids Res. 22 (19): 3825–3833. doi:10.1093/nar/22.19.3825. PMC 308376. PMID 7937100.
- Sumner C, Shinohara T, Durham L, Traub R, Major EO, Amemiya K (1996). "Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes". J. Neurovirol. 2 (2): 87–100. doi:10.3109/13550289609146542. PMID 8799200.
- Wendler WM, Kremmer E, Förster R, Winnacker EL (1997). "Identification of pirin, a novel highly conserved nuclear protein". J. Biol. Chem. 272 (13): 8482–8489. doi:10.1074/jbc.272.13.8482. PMID 9079676.
- Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing". J. Biol. Chem. 272 (16): 10739–10745. doi:10.1074/jbc.272.16.10739. PMID 9099724.
- Tarapore P, Richmond C, Zheng G, Cohen SB, Kelder B, Kopchick J, Kruse U, Sippel AE, Colmenares C, Stavnezer E (1997). "DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI". Nucleic Acids Res. 25 (19): 3895–3903. doi:10.1093/nar/25.19.3895. PMC 146989. PMID 9380514.
- Müller K, Mermod N (2000). "The histone-interacting domain of nuclear factor I activates simian virus 40 DNA replication in vivo". J. Biol. Chem. 275 (3): 1645–1650. doi:10.1074/jbc.275.3.1645. PMID 10636857.
- Nakazato M, Chung HK, Ulianich L, Grassadonia A, Suzuki K, Kohn LD (2000). "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression". Mol. Cell. Biol. 20 (22): 8499–8512. doi:10.1128/MCB.20.22.8499-8512.2000. PMC 102156. PMID 11046146.
- Imagawa M, Sakaue R, Tanabe A, Osada S, Nishihara T (2000). "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A". FEBS Lett. 484 (2): 118–124. doi:10.1016/S0014-5793(00)02119-0. PMID 11068044. S2CID 46556394.
- Norquay LD, Yang X, Sheppard P, Gregoire S, Dodd JG, Reith W, Cattini PA (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–1038. doi:10.1210/me.2003-0025. PMID 12624117.
- Gopalan SM, Wilczynska KM, Konik BS, Bryan L, Kordula T (2006). "Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes". J. Biol. Chem. 281 (19): 13126–13133. doi:10.1074/jbc.M601194200. PMID 16565071.
- Ravichandran V, Sabath BF, Jensen PN, Houff SA, Major EO (2006). "Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism". J. Virol. 80 (21): 10506–10513. doi:10.1128/JVI.01355-06. PMC 1641797. PMID 16928756.
외부 링크
- NFIX+단백질+미국 국립의학도서관의 의학 주제 제목(MeSH)
