MAPK8

MAPK8
MAPK8
Protein MAPK8 PDB 1jnk.png
사용 가능한 구조물
PDB직교 검색: PDBe RCSB
식별자
별칭MAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, 미토겐활성 단백질 키나아제 8
외부 IDOMIM: 601158 MGI: 1346861 HomoloGene: 56760 GeneCard: MAPK8
직교체
종인간마우스
엔트레스

5599

26419

앙상블

ENSG00000107643

ENSMUSG000021936

유니프로트

P45983

Q91Y86

RefSeq(mRNA)

NM_001310452
NM_001310453
NM_001310454
NM_016700

RefSeq(단백질)

NP_001297381
NP_001297382
NP_001297383
NP_057909

위치(UCSC)Chr 10: 48.31 – 48.44MbCr 14: 33.1 – 33.17Mb
PubMed 검색[3][4]
위키다타
인간 보기/편집마우스 보기/편집

미토겐 활성 단백질 키나아제 8(JNK1)은 인간 내에서도 MAPK8 유전자에 의해 암호화된 유비쿼터스 효소다.[5][6]

함수

이 유전자에 의해 암호화된 단백질은 MAP키나아제와 JNK 계열의 일원이다.MAP 키나제스는 복수의 생화학적 신호의 통합점 역할을 하며 증식, 분화, 전사 규제, 개발 등 매우 다양한 세포 과정에 관여한다.이 키나아제는 다양한 세포 자극에 의해 활성화되며, 특정 전사 인자를 대상으로 하므로 세포 자극에 반응하여 즉시 초기 유전자 발현을 매개한다.TNF-알파 유도 사멸에는 종양-괴사 인자 알파(TNF-알파)에 의한 이 키나아제의 활성화가 필요한 것으로 확인되었다.이 키나아제는 또한 자외선에 의한 세포사멸 경로와 관련이 있다고 생각되는 자외선에 의한 세포사멸에도 관여한다.이 유전자의 마우스 상대방에 대한 연구는 이 키나아제가 T 세포 증식, 세포사멸, 분화에 핵심적인 역할을 한다는 것을 시사했다.구별되는 ISO 양식을 인코딩하는 네 개의 번갈아 분할된 대본 변형들이 보고되었다.[7]MAPK8에는 인산염과 유비쿼터스 처리된 여러 아미노산 부위가 포함되어 있다.[8]

상호작용

MAPK8은 다음과 상호 작용하는 것으로 나타났다.

참조

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외부 링크

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.