RYBP

RYBP
사용 가능한 구조
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	3IXS
식별자
에일리어스	RYBP, AAP1, DEDAF, YEAF1, APAP-1, RING1, YY1결합단백질
외부 ID	OMIM : 607535 MGI : 3648043 HomoloGene : 8159 GenCard : RYBP
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	72,446,621 bp
RNA발현패턴
	상단 표시 위치:
	폐하엽; ; 내피 세포; ; 결석골; ; 요도; ; 해마의 고유 영역 I; ; 중전두회; ; 시신경; ; 태반; ; 미주신경의 하부 신경절; ; 내장 흉막;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; GO:0001948 단백질 결합; GO:0001106 전사 코어프레서 액티비티; 금속 이온 결합;
셀룰러 컴포넌트	세포질; PcG단백질복합체; 핵; 핵소체;
생물학적 과정	다세포 생물 발달; 히스톤 H2A 단염화; 전사조절, DNA템플릿화; 전사, DNA 템플릿; 아포토시스 과정; RNA중합효소II에 의한 전사 음성 조절; 프로테아좀유비퀴틴의존성단백질이화과정음성조절; 아포토시스 과정의 양성 조절; 전사의 양성 조절, DNA 템플릿화; G0에서 G1로의 이행에 대한 부정적 조절;
	출처:아미고 / QuickGO
맞춤법
	23429
	628746
	ENSG00000281766; ENSG00000163602
	없음
	Q8N488
	없음
	NM_012234
	XM_036158262
	NP_036366
	없음
	위키데이터
인간 보기/편집	마우스 표시/편집

RING1 및 YY1 결합 단백질은 RYBP ^[4]^[5]유전자에 의해 인체 내에서 암호화되는 단백질이다.

상호 작용

RYBP는 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c ENSG00000163602 GRCh38: 앙상블 릴리즈 89: ENSG00000281766, ENSG00000163602 - Ensembl, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c ^d García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
^ "Entrez Gene: RYBP RING1 and YY1 binding protein".
^ Zhu J, Shore SK (Dec 1996). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein". Molecular and Cellular Biology. 16 (12): 7054–62. doi:10.1128/mcb.16.12.7054. PMC 231708. PMID 8943360.
^ Zheng L, Schickling O, Peter ME, Lenardo MJ (Aug 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". The Journal of Biological Chemistry. 276 (34): 31945–52. doi:10.1074/jbc.M102799200. PMID 11395500.
^ ^a ^b Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
^ Chen D, Zhang J, Li M, Rayburn ER, Wang H, Zhang R (Feb 2009). "RYBP stabilizes p53 by modulating MDM2". EMBO Reports. 10 (2): 166–72. doi:10.1038/embor.2008.231. PMC 2637313. PMID 19098711.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

추가 정보

Zhu J, Shore SK (Dec 1996). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein". Molecular and Cellular Biology. 16 (12): 7054–62. doi:10.1128/mcb.16.12.7054. PMC 231708. PMID 8943360.
Trimarchi JM, Fairchild B, Wen J, Lees JA (Feb 2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMC 29289. PMID 11171983.
Zheng L, Schickling O, Peter ME, Lenardo MJ (Aug 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". The Journal of Biological Chemistry. 276 (34): 31945–52. doi:10.1074/jbc.M102799200. PMID 11395500.
Sawa C, Yoshikawa T, Matsuda-Suzuki F, Deléhouzée S, Goto M, Watanabe H, Sawada J, Kataoka K, Handa H (Jun 2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". The Journal of Biological Chemistry. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
Guelen L, Paterson H, Gäken J, Meyers M, Farzaneh F, Tavassoli M (Feb 2004). "TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells". Oncogene. 23 (5): 1153–65. doi:10.1038/sj.onc.1207224. PMID 14691460.
Danen-van Oorschot AA, Voskamp P, Seelen MC, van Miltenburg MH, Bolk MW, Tait SW, Boesen-de Cock JG, Rohn JL, Borst J, Noteborn MH (May 2004). "Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing". Cell Death and Differentiation. 11 (5): 564–73. doi:10.1038/sj.cdd.4401391. PMID 14765135.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

인간 염색체 3번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] ENSG00000163602 GRCh38: 앙상블 릴리즈 89: ENSG00000281766, ENSG00000163602 - Ensembl, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10369680-4] García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.

[entrez-5] "Entrez Gene: RYBP RING1 and YY1 binding protein".

[pmid8943360-6] Zhu J, Shore SK (Dec 1996). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein". Molecular and Cellular Biology. 16 (12): 7054–62. doi:10.1128/mcb.16.12.7054. PMC 231708. PMID 8943360.

[pmid11395500-7] Zheng L, Schickling O, Peter ME, Lenardo MJ (Aug 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". The Journal of Biological Chemistry. 276 (34): 31945–52. doi:10.1074/jbc.M102799200. PMID 11395500.

[pmid12411495-8] Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.

[pmid19098711-9] Chen D, Zhang J, Li M, Rayburn ER, Wang H, Zhang R (Feb 2009). "RYBP stabilizes p53 by modulating MDM2". EMBO Reports. 10 (2): 166–72. doi:10.1038/embor.2008.231. PMC 2637313. PMID 19098711.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

Search

RYBP

네임스페이스

더

상호 작용

레퍼런스

추가 정보