SPI1
SPI1
전사 계수 PU.1은 인간에서 SPI1 유전자에 의해 암호화된 단백질이다.[5]
함수
이 유전자는 골수 세포와 B-림프모이드 세포 발달 동안 유전자 발현을 활성화시키는 ETS-영역 전사 인자를 인코딩한다.[6]이 핵 단백질은 표적 유전자의 증류기에서 발견된 PU-box라고 알려진 푸린이 풍부한 염기서열과 결합하고, 다른 전사 인자 및 공작용자들과 함께 이들의 발현을 조절한다.이 단백질은 또한 표적 유전자의 대체적인 스플리싱도 조절할 수 있다.이 유전자에 대해 서로 다른 ISO 양식을 인코딩하는 다중 대본 변형이 발견되었다.[7]
구조
ETS 영역은 PU.1 및 기타 ETS-패밀리 전사 인자의 DNA 결합 모듈이다.
상호작용
SPI1은 다음과 상호 작용하는 것으로 나타났다.
참조
- ^ a b c GRCh38: 앙상블 릴리스 89: ENSG000066336 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000002111 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ray D, Culine S, Tavitain A, Moreau-Gachelin F (July 1990). "The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–668. PMID 1693183.
- ^ Oikawa, T; Yamada, T; Kihara-Negishi, F; Yamamoto, H; Kondoh, N; Hitomi, Y; Hashimoto, Y (July 1999). "The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis". Cell Death Differ. 6 (7): 599–608. doi:10.1038/sj.cdd.4400534. PMID 10453070.
- ^ "Entrez Gene: SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1".
- ^ Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F (February 1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838–4842. doi:10.1074/jbc.273.9.4838. PMID 9478924.
- ^ Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z (July 1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8705–8710. Bibcode:1999PNAS...96.8705Z. doi:10.1073/pnas.96.15.8705. PMC 17580. PMID 10411939.
- ^ Brass AL, Zhu AQ, Singh H (February 1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4): 977–991. doi:10.1093/emboj/18.4.977. PMC 1171190. PMID 10022840.
- ^ Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK (July 2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. 139 (1): 55–59. doi:10.1016/s1047-8477(02)00514-2. PMID 12372320.
- ^ Hallier M, Tavitian A, Moreau-Gachelin F (May 1996). "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". J. Biol. Chem. 271 (19): 11177–11181. doi:10.1074/jbc.271.19.11177. PMID 8626664.
추가 읽기
- Klemsz MJ, McKercher SR, Celada A, Van Beveren C, Maki RA (1990). "The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene". Cell. 61 (1): 113–124. doi:10.1016/0092-8674(90)90219-5. PMID 2180582. S2CID 27819155.
- Nguyen VC, Ray D, Gross MS, de Tand MF, Frézal J, Moreau-Gachelin F (1990). "Localization of the human oncogene SPI1 on chromosome 11, region p11.22". Hum. Genet. 84 (6): 542–546. doi:10.1007/bf00210807. PMID 2338340. S2CID 22337200.
- Chen H, Ray-Gallet D, Zhang P, Hetherington CJ, Gonzalez DA, Zhang DE, Moreau-Gachelin F, Tenen DG (1995). "PU.1 (Spi-1) autoregulates its expression in myeloid cells". Oncogene. 11 (8): 1549–1560. PMID 7478579.
- Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". J. Immunol. 155 (9): 4330–4338. PMID 7594592.
- Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3′ enhancer". J. Biol. Chem. 270 (17): 10304–10313. doi:10.1074/jbc.270.17.10304. PMID 7730336.
- Hromas R, Orazi A, Neiman RS, Maki R, Van Beveran C, Moore J, Klemsz M (1993). "Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1". Blood. 82 (10): 2998–3004. doi:10.1182/blood.V82.10.2998.2998. PMID 8219191.
- Hagemeier C, Bannister AJ, Cook A, Kouzarides T (1993). "The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB". Proc. Natl. Acad. Sci. U.S.A. 90 (4): 1580–1584. Bibcode:1993PNAS...90.1580H. doi:10.1073/pnas.90.4.1580. PMC 45918. PMID 8434021.
- Hallier M, Tavitian A, Moreau-Gachelin F (1996). "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". J. Biol. Chem. 271 (19): 11177–11181. doi:10.1074/jbc.271.19.11177. PMID 8626664.
- Bassuk AG, Anandappa RT, Leiden JM (1997). "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells". J. Virol. 71 (5): 3563–3573. doi:10.1128/JVI.71.5.3563-3573.1997. PMC 191503. PMID 9094628.
- Li SL, Valente AJ, Zhao SJ, Clark RA (1997). "PU.1 is essential for p47(phox) promoter activity in myeloid cells". J. Biol. Chem. 272 (28): 17802–17809. doi:10.1074/jbc.272.28.17802. PMID 9211934.
- Tsukada J, Misago M, Serino Y, Ogawa R, Murakami S, Nakanishi M, Tonai S, Kominato Y, Morimoto I, Auron PE, Eto S (1997). "Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1". Blood. 90 (8): 3142–3153. doi:10.1182/blood.V90.8.3142. PMID 9376596.
- Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F (1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838–4842. doi:10.1074/jbc.273.9.4838. PMID 9478924.
- Suzuki S, Kumatori A, Haagen IA, Fujii Y, Sadat MA, Jun HL, Tsuji Y, Roos D, Nakamura M (1998). "PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6085–6090. Bibcode:1998PNAS...95.6085S. doi:10.1073/pnas.95.11.6085. PMC 27589. PMID 9600921.
- Carrère S, Verger A, Flourens A, Stehelin D, Duterque-Coquillaud M (1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains". Oncogene. 16 (25): 3261–3268. doi:10.1038/sj.onc.1201868. PMID 9681824.
- Sato M, Morii E, Takebayashi-Suzuki K, Yasui N, Ochi T, Kitamura Y, Nomura S (1999). "Microphthalmia-associated transcription factor interacts with PU.1 and c-Fos: determination of their subcellular localization". Biochem. Biophys. Res. Commun. 254 (2): 384–387. doi:10.1006/bbrc.1998.9918. PMID 9918847.
- Brass AL, Zhu AQ, Singh H (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4): 977–991. doi:10.1093/emboj/18.4.977. PMC 1171190. PMID 10022840.
- Yamamoto H, Kihara-Negishi F, Yamada T, Hashimoto Y, Oikawa T (1999). "Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP". Oncogene. 18 (7): 1495–1501. doi:10.1038/sj.onc.1202427. PMID 10050886.
- Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". J. Biol. Chem. 274 (16): 11115–11124. doi:10.1074/jbc.274.16.11115. PMID 10196196.
- Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Mol. Cell. Biol. 19 (5): 3635–3644. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
외부 링크
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