호모 사피엔스 종의 단백질 코드 유전자
DNA메틸전달효소1 관련단백질1 은 DMAP1 유전자에 [5] [6] [7] 효소 이다.
기능. 이 유전자는 전사의 억제 또는 활성화에 관여하는 여러 개의 서로 다른 복합체의 하위 단위를 암호화합니다. 암호화된 단백질은 독립적으로 전사를 억제할 수 있으며 DNA 메틸전달효소 1의 N 말단과 직접 상호작용함으로써 S상 전체의 복제 포시를 목표로 한다. 후기 S단계에서 히스톤탈아세틸라아제2가 이 복합체에 첨가되어 복제 후 전사적으로 비활성화된 헤테로크로마틴에서 히스톤을 탈아세틸화하는 수단을 제공한다. 암호화 단백질은 또한 H4 복합체의 뉴클레오솜 아세틸전달효소의 구성 요소이며, 특히 전사 코어프레서 종양 감수성 유전자 101 및 전아포토시스 사망 관련 단백질 6과 상호작용한다. 동일한 단백질을 코드하는 대체적으로 스플라이스된 전사 변이가 설명되었다.[7]
상호 작용 DMAP1은 다음 제품과 상호 작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000178028 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000009640 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Rountree MR, Bachman KE, Baylin SB (Aug 2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci". Nat Genet . 25 (3): 269–77. doi :10.1038/77023 . PMID 10888872 . S2CID 26149386 . ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (1): 65–73. doi :10.1093/dnares/7.1.65 PMID 10718198 . ^ a b "Entrez Gene: DMAP1 DNA methyltransferase 1 associated protein 1" .^ Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S (Oct 2004). "Subcellular localization of RPB5-mediating protein and its putative functional partner" . Mol. Cell. Biol . 24 (19): 8556–66. doi :10.1128/MCB.24.19.8556-8566.2004 . PMC 516735 PMID 15367675 . ^ Rountree MR, Bachman KE, Baylin SB (Jul 2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci". Nat. Genet . 25 (3): 269–77. doi :10.1038/77023 . PMID 10888872 . S2CID 26149386 . ^ Xin H, Yoon HG, Singh PB, Wong J, Qin J (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells" . J. Biol. Chem . 279 (10): 9539–46. doi :10.1074/jbc.M311587200 PMID 14665632 . ^ Liu Z, Fisher RA (Apr 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity" . J. Biol. Chem . 279 (14): 14120–8. doi :10.1074/jbc.M309547200 PMID 14734556 . 추가 정보 Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex". Curr. Opin. Genet. Dev . 14 (2): 147–54. doi :10.1016/j.gde.2004.02.009 . PMID 15196461 . Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys . 400 (1): 105–10. doi :10.1006/abbi.2002.2778 . PMID 11913976 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex" . J. Biol. Chem . 278 (44): 42733–6. doi :10.1074/jbc.C300389200 PMID 12963728 . Xin H, Yoon HG, Singh PB, et al. (2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells" . J. Biol. Chem . 279 (10): 9539–46. doi :10.1074/jbc.M311587200 PMID 14665632 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Liu Z, Fisher RA (2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity" . J. Biol. Chem . 279 (14): 14120–8. doi :10.1074/jbc.M309547200 PMID 14734556 . Doyon Y, Selleck W, Lane WS, et al. (2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans" . Mol. Cell. Biol . 24 (5): 1884–96. doi :10.1128/MCB.24.5.1884-1896.2004 . PMC 350560 PMID 14966270 . Muromoto R, Sugiyama K, Takachi A, et al. (2004). "Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1" . J. Immunol . 172 (5): 2985–93. doi :10.4049/jimmunol.172.5.2985 PMID 14978102 . Muromoto R, Sugiyama K, Yamamoto T, et al. (2004). "Physical and functional interactions between Daxx and TSG101". Biochem. Biophys. Res. Commun . 316 (3): 827–33. doi :10.1016/j.bbrc.2004.02.126 . hdl :2115/28120 PMID 15033475 . Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain" . Mol. Cell. Proteomics . 3 (11): 1093–101. doi :10.1074/mcp.M400085-MCP200 PMID 15345747 . Delgermaa L, Hayashi N, Dorjsuren D, et al. (2004). "Subcellular localization of RPB5-mediating protein and its putative functional partner" . Mol. Cell. Biol . 24 (19): 8556–66. doi :10.1128/MCB.24.19.8556-8566.2004 . PMC 516735 PMID 15367675 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes" . J. Biol. Chem . 280 (14): 13665–70. doi :10.1074/jbc.M500001200 PMID 15647280 .
