SWI/SNF 복합 서브유닛 SMARCC1은 SMARCC1 [5] [6] 단백질 이다.
기능. 이 유전자에 의해 코드된 단백질은 SWI /SNF 계열의 단백질로 구성원들은 헬리케이스 와 ATPase 활성을 나타내며 이들 유전자 주변의 염색질 구조를 변화시킴으로써 특정 유전자의 전사를 조절하는 것으로 생각된다. 암호화된 단백질은 ATP 의존성 크로마틴 리모델링 복합체 SWI/SNF의 일부이며 많은 전사 [6] 류신 지퍼 모티브를 포함합니다.
상호 작용 SMARCC1은 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000173473 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032481 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (November 1996). "Diversity and specialization of mammalian SWI/SNF complexes" . Genes Dev . 10 (17): 2117–30. doi :10.1101/gad.10.17.2117 PMID 8804307 . ^ a b "Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1" .^ Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (June 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome" . Cell . 113 (7): 905–17. doi :10.1016/s0092-8674(03)00436-7 PMID 12837248 . ^ a b Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)" . Mol. Cell. Biol . 22 (3): 835–48. doi :10.1128/mcb.22.3.835-848.2002 . PMC 133546 PMID 11784859 . ^ a b c d Sif S, Saurin AJ, Imbalzano AN, Kingston RE (March 2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes" . Genes Dev . 15 (5): 603–18. doi :10.1101/gad.872801 . PMC 312641 PMID 11238380 . ^ a b c Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex" . EMBO J . 15 (19): 5370–82. doi :10.1002/j.1460-2075.1996.tb00921.x . PMC 452280 PMID 8895581 . ^ Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM (November 2001). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex" . Hum. Mol. Genet . 10 (23): 2651–60. doi :10.1093/hmg/10.23.2651 PMID 11726552 . ^ Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (November 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling" . Cell . 95 (5): 625–36. doi :10.1016/s0092-8674(00)81633-5 PMID 9845365 . S2CID 3184211 . 추가 정보 Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex" . EMBO J . 15 (19): 5370–82. doi :10.1002/j.1460-2075.1996.tb00921.x . PMC 452280 PMID 8895581 . Fryer CJ, Archer TK (1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex". Nature . 393 (6680): 88–91. Bibcode :1998Natur.393...88F . doi :10.1038/30032 . PMID 9590696 . S2CID 2208522 . Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics . 51 (1): 140–3. doi :10.1006/geno.1998.5343 . PMID 9693044 . Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure" . Mol. Cell. Biol . 18 (9): 5355–63. doi :10.1128/MCB.18.9.5355 . PMC 109120 PMID 9710619 . Sif S, Stukenberg PT, Kirschner MW, Kingston RE (1998). "Mitotic inactivation of a human SWI/SNF chromatin remodeling complex" . Genes Dev . 12 (18): 2842–51. doi :10.1101/gad.12.18.2842 . PMC 317164 PMID 9744861 . Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (1999). "Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest" . Mol. Cell. Biol . 19 (2): 1460–9. doi :10.1128/mcb.19.2.1460 . PMC 116074 PMID 9891079 . Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits" . Mol. Cell . 3 (2): 247–53. doi :10.1016/S1097-2765(00)80315-9 PMID 10078207 . Kowenz-Leutz E, Leutz A (2000). "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes" . Mol. Cell . 4 (5): 735–43. doi :10.1016/S1097-2765(00)80384-6 PMID 10619021 . Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer" . Cell . 102 (2): 257–65. doi :10.1016/S0092-8674(00)00030-1 PMID 10943845 . S2CID 6500100 . Kadam S, McAlpine GS, Phelan ML, Kingston RE, Jones KA, Emerson BM (2000). "Functional selectivity of recombinant mammalian SWI/SNF subunits" . Genes Dev . 14 (19): 2441–51. doi :10.1101/gad.828000 . PMC 316972 PMID 11018012 . Xue Y, Canman JC, Lee CS, Nie Z, Yang D, Moreno GT, Young MK, Salmon ED, Wang W (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes" . Proc. Natl. Acad. Sci. U.S.A . 97 (24): 13015–20. doi :10.1073/pnas.240208597 PMC 27170 PMID 11078522 . Sif S, Saurin AJ, Imbalzano AN, Kingston RE (2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes" . Genes Dev . 15 (5): 603–18. doi :10.1101/gad.872801 . PMC 312641 PMID 11238380 . Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM (2002). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex" . Hum. Mol. Genet . 10 (23): 2651–60. doi :10.1093/hmg/10.23.2651 PMID 11726552 . Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones" . J. Biol. Chem . 277 (7): 5498–505. doi :10.1074/jbc.M108702200 PMID 11734557 . Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W (2003). "Novel SWI/SNF Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner" . Mol. Cell. Biol . 23 (8): 2942–52. doi :10.1128/MCB.23.8.2942-2952.2003 . PMC 152562 PMID 12665591 . Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome" . Cell . 113 (7): 905–17. doi :10.1016/S0092-8674(03)00436-7 PMID 12837248 . Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK (2003). "BAF60a Mediates Critical Interactions between Nuclear Receptors and the BRG1 Chromatin-Remodeling Complex for Transactivation" . Mol. Cell. Biol . 23 (17): 6210–20. doi :10.1128/MCB.23.17.6210-6220.2003 . PMC 180928 PMID 12917342 .
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