에스트로겐 관련 수용체 감마
Estrogen-related receptor gamma
NR3B3(핵수용체 서브 패밀리 3, 그룹 B, 멤버 3)라고도 알려진 에스트로겐 관련 수용체 감마(ERR-gamma)는 인간에서 ESRG([5][6][7]ESTrogen Related Receptor Gamma) 유전자에 의해 암호화되는 핵수용체이다.그것은 [8]전사의 구성적인 활성화제 역할을 한다.
이 단백질은 스테로이드 호르몬 수용체의 핵 호르몬 수용체 계열의 구성원이다.이 고아 수용체에 대해 알려진 생리활성화 리간드는 없지만 4-히드록시타목시펜과 디에틸스틸베스트롤은 역작용제로 작용하여 ESRG를 [9]비활성화한다.비스페놀 A(아래 참조)의 표적이기도 한 것 같습니다.
비스페놀A결합
비스페놀A는 ERR-에 [8]강하게 결합함으로써 제노에스트로겐으로 기능한다는 증거가 있으며, BPA와 질화 및 염소화 대사물은 ERR-에 강하게 결합하는 것으로 보이지만, ERR-에스트로겐 수용체(ER, BPA)와 결합하는 것은 아니다.[8][10][8]또한 선택적 에스트로겐 수용체 조절기 4-히드록시타목시펜으로부터의 [8]불활성화로부터 보호할 수 있다.
신체의 다른 부위에서 ERR-γ의 다른 발현은 비스페놀 A 효과의 변화를 설명할 수 있다.예를 들어 ERR-γ는 태반에서 고농도로 발견되어 비스페놀A가 [11]고농도로 축적되었다는 보고가 있다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000196482 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026610 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: ESRRG estrogen-related receptor gamma".
- ^ Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmadge CB, Cheng JJ, Kimberling WJ, Sumegi J (Jun 1998). "Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41". Genomics. 50 (3): 382–4. doi:10.1006/geno.1998.5345. PMID 9676434.
- ^ Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
- ^ a b c d e Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y (Oct 2007). "Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma". Journal of Biochemistry. 142 (4): 517–24. doi:10.1093/jb/mvm158. PMID 17761695.
- ^ Huppunen J, Aarnisalo P (Feb 2004). "Dimerization modulates the activity of the orphan nuclear receptor ERRgamma". Biochemical and Biophysical Research Communications. 314 (4): 964–70. doi:10.1016/j.bbrc.2003.12.194. PMID 14751226.
- ^ Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma". Biochemical and Biophysical Research Communications. 426 (2): 215–20. doi:10.1016/j.bbrc.2012.08.065. PMID 22935422.
- ^ Takeda Y, Liu X, Sumiyoshi M, Matsushima A, Shimohigashi M, Shimohigashi Y (Jul 2009). "Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform". Journal of Biochemistry. 146 (1): 113–22. doi:10.1093/jb/mvp049. PMID 19304792.
외부 링크
- "Master protein found to enhance both muscles and the brain". KurzweilAI. April 7, 2015.
추가 정보
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- Heard DJ, Norby PL, Holloway J, Vissing H (Mar 2000). "Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult". Molecular Endocrinology. 14 (3): 382–92. doi:10.1210/mend.14.3.0431. PMID 10707956.
- Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dorsselaer A, Moras D, Renaud JP (Feb 2002). "Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3". Molecular Cell. 9 (2): 303–13. doi:10.1016/S1097-2765(02)00444-6. PMID 11864604.
- Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
- Hentschke M, Süsens U, Borgmeyer U (Aug 2002). "Domains of ERRgamma that mediate homodimerization and interaction with factors stimulating DNA binding". European Journal of Biochemistry. 269 (16): 4086–97. doi:10.1046/j.1432-1033.2002.03102.x. PMID 12180985.
- Hentschke M, Süsens U, Borgmeyer U (Dec 2002). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochemical and Biophysical Research Communications. 299 (5): 872–9. doi:10.1016/S0006-291X(02)02753-5. PMID 12470660.
- Hentschke M, Schulze C, Süsens U, Borgmeyer U (Mar 2003). "Characterization of calmodulin binding to the orphan nuclear receptor Errgamma". Biological Chemistry. 384 (3): 473–82. doi:10.1515/BC.2003.053. PMID 12715898. S2CID 41163978.
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- Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma". Biochemical and Biophysical Research Communications. 426 (2): 215–20. doi:10.1016/j.bbrc.2012.08.065. PMID 22935422.
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