NFATC2

NFATC2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1A02, 1OWR, 1P7H, 1PZU, 2AS5, 2O93, 3QRF
식별자
에일리어스	NFATC2, NFATP1, NFATP, 활성화된 T세포2의 핵인자, 활성화된 T세포2의 핵인자
외부 ID	OMIM: 600490 MGI: 102463 HomoloGene: 7861 GenCard: NATC2
유전자 위치(인간)
크르.	20번 염색체(인간)
끝.	51,562,831 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	168,443,577 bp
RNA발현패턴
	상단 표시 위치:
	대정맥; ; 활액관절; ; 활막; ; 니플; ; 유문; ; 복정맥; ; 기관; ; 요도; ; 삼차신경절; ; 카디아;
	상단 표시 위치:
	운동 뉴런; ; 흑색 실체; ; 발목; ; 콘딜; ; 안면 운동핵; ; 발바닥근; ; 우심실; ; 척수 전각; ; 암요도; ; 피;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	DNA결합; 배열특이적 DNA결합; DNA결합전사인자활성; DNA결합전사활성화제, RNA중합효소II 특이적; 전사 인자 결합; 크로마틴 결합; RNA중합효소II 시스조절영역배열특이적 DNA결합; DNA결합전사억제제활성, RNA중합효소II 특이적; 단백질 결합; 전사 시스 조절 영역 결합; 포스파타아제결합; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	세포질; 전사조절복합체; 핵소체; 핵; 세포; 리보핵단백질복합체;
생물학적 과정	B세포수용체신호경로; 전사조절, DNA템플릿화; 사이토카인 생성; 칼시뉴린-NFAT 시그널링 캐스케이드; RNA중합효소II에 의한 전사 음성 조절; RNA중합효소II에 의한 전사; 근튜브세포발달; 전사, DNA 템플릿; DNA 손상 자극에 대한 세포 반응; 전사의 양성 조절, DNA 템플릿화; Fc-epsilon 수용체 시그널링 경로; 근아세포융합양조절; 유전자 발현 양성 조절; B세포 증식의 양성 조절; 세포이동; RNA중합효소II에 의한 전사의 양성 조절; 조절 T세포 분화 조절; 혈관관련 평활근세포분화음성조절;
	출처:아미고 / QuickGO
맞춤법
	4773
	18019
	ENSG000001096
	ENSMUSG000027544
	문제 13469
	문제 60591
NM_001136021; NM_001258292; NM_001258294; NM_001258295; NM_001258296;
	NM_001258297; NM_012340; NM_173091
NM_001037177; NM_001037178; NM_001136073; NM_001291168; NM_001291169;
	NM_001291170; NM_001291171; NM_001291172; NM_001291173; NM_001291174; NM_001291175; NM_001291176; NM_001291177; NM_001291178; NM_001291179; NM_010899
NP_001129493; NP_001245221; NP_001245223; NP_001245224; NP_001245225;
	NP_001245226; NP_036472; NP_775114
NP_001032254; NP_001032255; NP_001129545; NP_001278097; NP_001278098;
	NP_001278099; NP_001278100; NP_001278101; NP_001278102; NP_001278103; NP_001278104; NP_001278105; NP_001278106; NP_001278107; NP_001278108; NP_035029
	위키데이터
인간 보기/편집	마우스 표시/편집

활성화된 T세포의 핵인자인 세포질 2는 사람에게서 NFATC2 유전자에 ^[5]의해 암호화되는 단백질이다.

기능.

이 유전자는 활성화된 T세포(NFAT) 계열의 핵 인자의 구성원이다.이 유전자의 산물은 REL-호몰로지 영역(RHR)과 NFAT-호몰로지 영역(NHR)을 가진 DNA 결합 단백질이다.이 단백질은 세포에 존재하며 T세포 수용체(TCR) 자극 시에만 핵으로 이동하며, 활성화된 T세포 전사 복합체의 핵 인자의 구성원이 된다.이 복합체는 면역 반응 동안 유전자 전사를 유도하는 데 중심적인 역할을 한다.다른 Isoform을 인코딩하는 대체 전사 스플라이스 변형이 ^[6]특징지어졌습니다.

임상적 의의

EWSR1 유전자와 NFATc2 유전자 사이의 프레임 내 융합 생성물을 형성하는 전위치는 유잉 육종과 유사한 임상 외관을 가진 골종에서 기술되었다.전위파단점은 NFATC2 단백질의 제어원소를 상실하게 하고 EWSR1 유전자의 N 말단 영역의 융합으로 ^[7]단백질의 지속적인 활성화를 부여했다.

상호 작용

NFATC2는 MEF2D,^[8] EP300,^[9] IRF4^[10], 단백질인산화효소 M ^[11]m과 상호작용하는 것으로 나타났다. 프로스타글란딘 F2alpha는 골격근 ^[12]세포의 성장을 자극하는 NFCT2 경로를 자극한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000001096 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027544 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR (Jun 1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature. 369 (6480): 497–502. Bibcode:1994Natur.369..497N. doi:10.1038/369497a0. PMID 8202141. S2CID 9920546.
^ "Entrez Gene: NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2".
^ Szuhai K, Ijszenga M, de Jong D, Karseladze A, Tanke HJ, Hogendoorn PC (Apr 2009). "The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology". Clinical Cancer Research. 15 (7): 2259–68. doi:10.1158/1078-0432.CCR-08-2184. PMID 19318479.
^ Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–31. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.
^ García-Rodríguez C, Rao A (Jun 1998). "Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)". The Journal of Experimental Medicine. 187 (12): 2031–6. doi:10.1084/jem.187.12.2031. PMC 2212364. PMID 9625762.
^ Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH (Apr 2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". The Journal of Experimental Medicine. 195 (8): 1003–12. doi:10.1084/jem.20011128. PMC 2193700. PMID 11956291.
^ San-Antonio B, Iñiguez MA, Fresno M (Jul 2002). "Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity". The Journal of Biological Chemistry. 277 (30): 27073–80. doi:10.1074/jbc.M106983200. PMID 12021260.
^ Horsley V, Pavlath GK (2003). "Prostaglandin F2(alpha) stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway". J Cell Biol. 161 (1): 111–8. doi:10.1083/jcb.200208085. PMC 2172881. PMID 12695501.

추가 정보

Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology. 15: 707–747. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
Crabtree GR (Mar 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–614. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. S2CID 8817053.
Horsley V, Pavlath GK (Mar 2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology. 156 (5): 771–774. doi:10.1083/jcb.200111073. PMC 2173310. PMID 11877454.
Aramburu J, Azzoni L, Rao A, Perussia B (Sep 1995). "Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding". The Journal of Experimental Medicine. 182 (3): 801–810. doi:10.1084/jem.182.3.801. PMC 2192167. PMID 7650486.
Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B (Feb 1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree GR, Francke U (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenetics and Cell Genetics. 68 (3–4): 185–191. doi:10.1159/000133910. PMID 7842733.
Ho S, Timmerman L, Northrop J, Crabtree GR (1995). "Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT". Advances in Experimental Medicine and Biology. 365: 167–73. doi:10.1007/978-1-4899-0987-9_17. ISBN 978-1-4899-0989-3. PMID 7887301.
Jabado N, Le Deist F, Fisher A, Hivroz C (Nov 1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology. 24 (11): 2646–2652. doi:10.1002/eji.1830241112. PMID 7957556. S2CID 30435577.
Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A (Nov 1994). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications. 205 (1): 467–474. doi:10.1006/bbrc.1994.2689. PMID 7999066.
Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, Rao A (Sep 1993). "The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun". Nature. 365 (6444): 352–355. Bibcode:1993Natur.365..352J. doi:10.1038/365352a0. PMID 8397339. S2CID 4283223.
Luo C, Burgeon E, Carew JA, McCaffrey PG, Badalian TM, Lane WS, Hogan PG, Rao A (Jul 1996). "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes". Molecular and Cellular Biology. 16 (7): 3955–66. doi:10.1128/mcb.16.7.3955. PMC 231392. PMID 8668213.
Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT (Sep 1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology. 26 (9): 2181–2188. doi:10.1002/eji.1830260933. PMID 8814265. S2CID 23430217.
Copeland KF, McKay PJ, Rosenthal KL (Jan 1996). "Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element". AIDS Research and Human Retroviruses. 12 (2): 143–148. doi:10.1089/aid.1996.12.143. PMID 8834464.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hodge MR, Chun HJ, Rengarajan J, Alt A, Lieberson R, Glimcher LH (Dec 1996). "NF-AT-Driven interleukin-4 transcription potentiated by NIP45". Science. 274 (5294): 1903–1905. Bibcode:1996Sci...274.1903H. doi:10.1126/science.274.5294.1903. PMID 8943202. S2CID 29436825.
Lyakh L, Ghosh P, Rice NR (May 1997). "Expression of NFAT-family proteins in normal human T cells". Molecular and Cellular Biology. 17 (5): 2475–84. doi:10.1128/mcb.17.5.2475. PMC 232096. PMID 9111316.
Amasaki Y, Masuda ES, Imamura R, Arai K, Arai N (Mar 1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". Journal of Immunology. 160 (5): 2324–33. PMID 9498773.
Chen L, Glover JN, Hogan PG, Rao A, Harrison SC (Mar 1998). "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA". Nature. 392 (6671): 42–48. Bibcode:1998Natur.392...42C. doi:10.1038/32100. PMID 9510247. S2CID 4305535.

외부 링크

NFATC2+단백질+미국 국립의학도서관 의학 과목 제목(MeSH)

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000001096 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000027544 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8202141-5] Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR (Jun 1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature. 369 (6480): 497–502. Bibcode:1994Natur.369..497N. doi:10.1038/369497a0. PMID 8202141. S2CID 9920546.

[6] "Entrez Gene: NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2".

[pmid19318479-7] Szuhai K, Ijszenga M, de Jong D, Karseladze A, Tanke HJ, Hogendoorn PC (Apr 2009). "The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology". Clinical Cancer Research. 15 (7): 2259–68. doi:10.1158/1078-0432.CCR-08-2184. PMID 19318479.

[pmid10944115-8] Youn HD, Chatila TA, Liu JO (Aug 2000). "Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis". The EMBO Journal. 19 (16): 4323–31. doi:10.1093/emboj/19.16.4323. PMC 302027. PMID 10944115.

[pmid9625762-9] García-Rodríguez C, Rao A (Jun 1998). "Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)". The Journal of Experimental Medicine. 187 (12): 2031–6. doi:10.1084/jem.187.12.2031. PMC 2212364. PMID 9625762.

[pmid11956291-10] Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH (Apr 2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". The Journal of Experimental Medicine. 195 (8): 1003–12. doi:10.1084/jem.20011128. PMC 2193700. PMID 11956291.

[pmid12021260-11] San-Antonio B, Iñiguez MA, Fresno M (Jul 2002). "Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity". The Journal of Biological Chemistry. 277 (30): 27073–80. doi:10.1074/jbc.M106983200. PMID 12021260.

[pmid12695501-12] Horsley V, Pavlath GK (2003). "Prostaglandin F2(alpha) stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway". J Cell Biol. 161 (1): 111–8. doi:10.1083/jcb.200208085. PMC 2172881. PMID 12695501.

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