GTF2F1

GTF2F1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1F3U, 1I27, 1J2X, 1NHA, 1ONV, 2K7L, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
식별자
에일리어스	GTF2F1, 일반전사인자 IIF, 폴리펩타이드1, 74kDa, BTF4, RAP74, TF2F1, TFIF, 일반전사인자 IIF 서브유닛1
외부 ID	OMIM : 189968 MGI : 1923848 HomoloGene : 1585 GenCard : GTF2F1
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	6,393,981 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	57,318,288 bp
RNA발현패턴
	상단 표시 위치:
	소뇌; ; 소뇌 피질; ; 소뇌 반구; ; 전전두피질; ; 뇌하수체 전엽; ; 상전두회; ; 상부 신경; ; 췌장체; ; 신경절 융기; ; 배측 전전두피질;
	상단 표시 위치:
	작은 구멍; ; 광학 플래코드; ; 정관; ; 원시적 특징; ; 노른자낭; ; 운동 뉴런; ; 광상핵; ; 파네스 세포; ; 거울; ; 모낭;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	DNA결합; 전사공활성화제활성; 전사 인자 결합; 단백질 결합; 포스파타아제활성화제; RNA결합; 단백질인산가수분해효소결합; 단백질 도메인 특이 결합; RNA중합효소II일반전사인자활성; 프로모터 특이 크로마틴 결합;
셀룰러 컴포넌트	세포막내소기관; 핵소체; 전사인자 TFIIF복합체; 세포 접합; 전사인자 TFIID복합체; 핵; 단백질 함유 복합체;
생물학적 과정	mRNA 스플라이싱, 스플라이싱 경유; 전사조절, DNA템플릿화; RNA중합효소II 프로모터로부터의 전사 신장; 바이러스에 대한 반응; 7-메틸구아노신mRNA캡핑; RNA중합효소II에 의한 전사; 전사, DNA 템플릿; 바이러스 전사의 양성 조절; RNA중합효소II 프로모터로부터의 전사 개시; RNA중합효소II 프로모터로부터의 전사 신장 양성 조절; RNA중합효소II에 의한 전사의 양성 조절; RNA중합효소II에 의한 snRNA 전사; 섬유아세포증식인자수용체신호경로; 촉매 활성의 양성 조절; RNA대사과정; 단백질 결합의 음성 조절;
	출처:아미고 / QuickGO
맞춤법
	2962
	98053
	ENSG00000125651
	ENSMUSG00000002658
	P35269
	문제 3THK3
	NM_002096
	NM_133801
	NP_002087
	NP_598562
	위키데이터
인간 보기/편집	마우스 표시/편집

일반전사인자 IIF 서브유닛1은 GTF2F1 ^[5]^[6]유전자에 의해 인체 내에서 부호화되는 단백질이다.

상호 작용

GTF2F1은 다음과 상호작용하는 것으로 나타났습니다.

「」를 참조해 주세요.

전사율 II F

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000125651 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002658 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.
^ "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".
^ Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
^ ^a ^b ^c ^d ^e ^f Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
^ Kim MK, Nikodem VM (October 1999). "hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation". Mol. Cell. Biol. 19 (10): 6833–44. doi:10.1128/MCB.19.10.6833. PMC 84680. PMID 10490622.
^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662.
^ Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (September 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.
^ Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode:1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423. S2CID 47196160.
^ Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi:10.1016/S0021-9258(17)41889-8. PMID 8106390.
^ Dikstein R, Ruppert S, Tjian R (March 1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74". Cell. 84 (5): 781–90. doi:10.1016/s0092-8674(00)81055-7. PMID 8625415. S2CID 18490534.
^ ^a ^b Ruppert S, Tjian R (November 1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation". Genes Dev. 9 (22): 2747–55. doi:10.1101/gad.9.22.2747. PMID 7590250.
^ Siegert JL, Robbins PD (January 1999). "Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250". Mol. Cell. Biol. 19 (1): 846–54. doi:10.1128/MCB.19.1.846. PMC 83941. PMID 9858607.
^ ^a ^b Malik S, Guermah M, Roeder RG (March 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.
^ Fang SM, Burton ZF (May 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi:10.1074/jbc.271.20.11703. PMID 8662660.

추가 정보

Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
Aso T, Vasavada HA, Kawaguchi T, Germino FJ, Ganguly S, Kitajima S, Weissman SM, Yasukochi Y (1992). "Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF". Nature. 355 (6359): 461–4. Bibcode:1992Natur.355..461A. doi:10.1038/355461a0. PMID 1734283. S2CID 4312708.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Ruppert S, Tjian R (1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation". Genes Dev. 9 (22): 2747–55. doi:10.1101/gad.9.22.2747. PMID 7590250.
Hisatake K, Ohta T, Takada R, Guermah M, Horikoshi M, Nakatani Y, Roeder RG (1995). "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors". Proc. Natl. Acad. Sci. U.S.A. 92 (18): 8195–9. Bibcode:1995PNAS...92.8195H. doi:10.1073/pnas.92.18.8195. PMC 41123. PMID 7667268.
Joliot V, Demma M, Prywes R (1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode:1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423. S2CID 47196160.
Zhu H, Joliot V, Prywes R (1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi:10.1016/S0021-9258(17)41889-8. PMID 8106390.
Yonaha M, Aso T, Kobayashi Y, Vasavada H, Yasukochi Y, Weissman SM, Kitajima S (1993). "Domain structure of a human general transcription initiation factor, TFIIF". Nucleic Acids Res. 21 (2): 273–9. doi:10.1093/nar/21.2.273. PMC 309103. PMID 8441635.
Aso T, Tsai P, Kawaguchi T, Menninger JC, Kitajima S, Yasukochi Y, Ward DC, Weissman SM (1993). "Assignment of the human GTF2F1 gene to chromosome 19p13.3". Genomics. 16 (1): 252–3. doi:10.1006/geno.1993.1168. PMID 8486367.
Dikstein R, Ruppert S, Tjian R (1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74". Cell. 84 (5): 781–90. doi:10.1016/S0092-8674(00)81055-7. PMID 8625415. S2CID 18490534.
Fang SM, Burton ZF (1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi:10.1074/jbc.271.20.11703. PMID 8662660.
McEwan IJ, Dahlman-Wright K, Ford J, Wright AP (1996). "Functional interaction of the c-Myc transactivation domain with the TATA binding protein: evidence for an induced fit model of transactivation domain folding". Biochemistry. 35 (29): 9584–93. doi:10.1021/bi960793v. PMID 8755740.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID 8934526. S2CID 4278432.
Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC 232028. PMID 9121429.
Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
McEwan IJ, Gustafsson J (1997). "Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8485–90. Bibcode:1997PNAS...94.8485M. doi:10.1073/pnas.94.16.8485. PMC 22967. PMID 9238003.
Newberry EP, Latifi T, Battaile JT, Towler DA (1997). "Structure-function analysis of Msx2-mediated transcriptional suppression". Biochemistry. 36 (34): 10451–62. doi:10.1021/bi971008x. PMID 9265625.
O'Brien T, Tjian R (1998). "Functional analysis of the human TAFII250 N-terminal kinase domain". Mol. Cell. 1 (6): 905–11. doi:10.1016/S1097-2765(00)80089-1. PMID 9660973.

외부 링크

GTF2F1+단백질+인간(미국 국립의학도서관 의학 과목 표제(MeSH))
팩터북 GTF2F1

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000125651 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002658 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1734284-5] Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.

[entrez-6] "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".

[pmid9765293-7] Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.

[pmid9159119-8] ^ ^a ^b ^c ^d ^e ^f Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.

[pmid10490622-9] Kim MK, Nikodem VM (October 1999). "hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation". Mol. Cell. Biol. 19 (10): 6833–44. doi:10.1128/MCB.19.10.6833. PMC 84680. PMID 10490622.

[pmid9315662-10] Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662.

[pmid9710619-11] Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (September 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.

[pmid7854423-12] Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode:1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423. S2CID 47196160.

[pmid8106390-13] Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi:10.1016/S0021-9258(17)41889-8. PMID 8106390.

[pmid8625415-14] Dikstein R, Ruppert S, Tjian R (March 1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74". Cell. 84 (5): 781–90. doi:10.1016/s0092-8674(00)81055-7. PMID 8625415. S2CID 18490534.

[pmid7590250-15] Ruppert S, Tjian R (November 1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation". Genes Dev. 9 (22): 2747–55. doi:10.1101/gad.9.22.2747. PMID 7590250.

[pmid9858607-16] Siegert JL, Robbins PD (January 1999). "Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250". Mol. Cell. Biol. 19 (1): 846–54. doi:10.1128/MCB.19.1.846. PMC 83941. PMID 9858607.

[pmid9482861-17] Malik S, Guermah M, Roeder RG (March 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.

[pmid8662660-18] Fang SM, Burton ZF (May 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi:10.1074/jbc.271.20.11703. PMID 8662660.

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GTF2F1

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GTF2F1

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