XPB
XPB
XPB(xeroderma antexosum type B)는 TFIIH 전사 계수 복합체의 일부인 인간의 ATP 의존 DNA 헬리코아제다.
구조
XPB의 고고학적 호몰로로그의 3D 구조는 Scripps 연구소의 존 타이너 박사와 그의 그룹에 의해 X선 결정학에 의해 해결되었다.[5]
함수
XPB는 정상적인 기저 전사, 전사 결합 수리(TCR), 뉴클레오티드 절연 수리(NER)에서 중요한 역할을 한다.정제된 XPB는 3'-5'의 극성으로 DNA를 풀어준다.
NER에서 XPB(ERCC3) 단백질의 기능은 손상이 처음 인식된 후 DNA 이중나선을 푸는 것을 돕는 것이다.NER은 정상적인 염기쌍을 왜곡하는 광범위한 DNA 손상을 제거하는 다단계 경로다.그러한 손상은 부피가 큰 화학적 유도체, 자외선에 의한 피리미딘 다이머, 그리고 몇 가지 형태의 산화적 손상을 포함한다.XPB(ERCC3) 유전자의 돌연변이는 인간에서 코카인 증후군(XPCS)과 결합된 XP(Xeroderma fluexosum) 또는 XP로 이어질 수 있다.[6]XPCS 표현형을 가진 개개인의 돌연변이 XPB 세포는 UV 조사와 급성 산화 스트레스에 민감하다.[7]
장애
XPB와 다른 관련 보완 그룹인 XPA-XPG의 돌연변이는 제로데르마 색소증후군, 코카인 증후군, 삼초티오디스트로피와 같은 많은 유전적 질환을 유발한다.
상호작용
XPB는 다음과 상호 작용하는 것으로 나타났다.
소분자억제제
일반전사계수 TFIIH의 XPB 소단위 억제를 통해 포유류 전사를 억제하는 트립톨라이드(Triptolide)와 같은 강력한 생체활성 천연물이 최근 포도당 전달체 발현량이 증가한 저독성 암세포를 대상으로 하는 포도당 결합제로 보고되고 있다.[18]
참고 항목
참조
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- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000024382 - 앙상블, 2017년 5월
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추가 읽기
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외부 링크
- 제로데르마 색소의 GeneReviews/NIH/NCBI/UW 항목
- XPBC-ERCC-3+단백질 미국 국립 의학 도서관 제목(MSH)
