GTF3A

GTF3A
식별자
에일리어스	GTF3A, AP2, TFIIIA, 일반전사인자 IIIA
외부 ID	OMIM : 600860 MGI : 1913846 HomoloGene : 55630 GenCard : GTF3A
유전자 위치(인간)
크르.	13번 염색체(인간)
끝.	27,435,823 bp
유전자 위치(마우스)
크르.	5번 염색체(쥐)
끝.	146,892,424 bp
RNA발현패턴
	상단 표시 위치:
	이하선; ; 우심실; ; 중측두회; ; 상완 이두근; ; 흉부 횡격막; ; 안검결막; ; 설체; ; 위근; ; 좌심실; ; 상완 삼두근;
	상단 표시 위치:
	광학 플래코드; ; 작은 구멍; ; 복벽; ; 원시적 특징; ; 신경관; ; 신장 소체; ; 외경동맥; ; 내경동맥; ; 내측 신경절 융기; ; 혈관 형성;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	핵산 결합; DNA결합; 금속 이온 결합; RNA결합; 5S rRNA 결합; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵; 핵소체;
생물학적 과정	rRNA 전사; 전사조절, DNA템플릿화; 전사, DNA 템플릿; RNA중합효소III에 의한 전사; 리보솜대형 서브유닛생성; 리보솜생성; RNA중합효소II에 의한 전사조절;
	출처:아미고 / QuickGO
맞춤법
	2971
	66596
	ENSG00000122034
	ENSMUSG000016503
	Q92664
	Q8VHT7
	NM_002097
	NM_025652
	NP_002088
	NP_079928
	위키데이터
인간 보기/편집	마우스 표시/편집

전사인자 IIIA는 인간에서 GTF3A 유전자에 ^[5]^[6]의해 암호화되는 단백질이다.그것은 1988년 울프와 브라운에 의해 처음 분리되고 특징지어졌다.

Xenopus의 TFIIIA는 최초로 발견된 ^[7]아연 손가락 단백질이었다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000122034 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000016503 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, et al. (Jul 1995). "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA". Cytogenetics and Cell Genetics. 70 (3–4): 235–8. doi:10.1159/000134041. PMID 7789179.
^ "Entrez Gene: GTF3A general transcription factor IIIA".
^ Bruno M, Mahgoub M, Macfarlan TS (December 2019). "The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals". Annual Review of Genetics. Annual Reviews. 53 (1): 393–416. doi:10.1146/annurev-genet-112618-043717. PMID 31518518.

추가 정보

Murphy JE, Keen JH (May 1992). "Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia". The Journal of Biological Chemistry. 267 (15): 10850–5. doi:10.1016/S0021-9258(19)50096-5. PMID 1587861.
Seifart KH, Wang L, Waldschmidt R, Jahn D, Wingender E (January 1989). "Purification of human transcription factor IIIA and its interaction with a chemically synthesized gene encoding human 5 S rRNA". The Journal of Biological Chemistry. 264 (3): 1702–9. doi:10.1016/S0021-9258(18)94243-2. PMID 2912980.
Drew PD, Nagle JW, Canning RD, Ozato K, Biddison WE, Becker KG (July 1995). "Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA". Gene. 159 (2): 215–8. doi:10.1016/0378-1119(95)00145-V. PMID 7622052.
Moorefield B, Roeder RG (August 1994). "Purification and characterization of human transcription factor IIIA". The Journal of Biological Chemistry. 269 (33): 20857–65. doi:10.1016/S0021-9258(17)31901-4. PMID 8063702.
Fridell RA, Fischer U, Lührmann R, Meyer BE, Meinkoth JL, Malim MH, Cullen BR (April 1996). "Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev". Proceedings of the National Academy of Sciences of the United States of America. 93 (7): 2936–40. Bibcode:1996PNAS...93.2936F. doi:10.1073/pnas.93.7.2936. PMC 39738. PMID 8610146.
Oettel S, Härtel F, Kober I, Iben S, Seifart KH (June 1997). "Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes". Nucleic Acids Research. 25 (12): 2440–7. doi:10.1093/nar/25.12.2440. PMC 146769. PMID 9171097.
Moreland RJ, Dresser ME, Rodgers JS, Roe BA, Conaway JW, Conaway RC, Hanas JS (May 2000). "Identification of a transcription factor IIIA-interacting protein". Nucleic Acids Research. 28 (9): 1986–93. doi:10.1093/nar/28.9.1986. PMC 103300. PMID 10756201.
Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, et al. (November 2001). "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors". Molecular and Cellular Biology. 21 (22): 7796–806. doi:10.1128/MCB.21.22.7796-7806.2001. PMC 99949. PMID 11604514.
Hanas JS, Hocker JR, Cheng YG, Lerner MR, Brackett DJ, Lightfoot SA, et al. (January 2002). "cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA". Gene. 282 (1–2): 43–52. doi:10.1016/S0378-1119(01)00796-X. PMID 11814676.
Weser S, Riemann J, Seifart KH, Meissner W (May 2003). "Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene". Nucleic Acids Research. 31 (9): 2408–16. doi:10.1093/nar/gkg345. PMC 154231. PMID 12711686.
Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma VM (November 2004). "Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis". Clinical Cancer Research. 10 (22): 7621–8. doi:10.1158/1078-0432.CCR-04-1061. PMID 15569994.
Paing MM, Johnston CA, Siderovski DP, Trejo J (April 2006). "Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization". Molecular and Cellular Biology. 26 (8): 3231–42. doi:10.1128/MCB.26.8.3231-3242.2006. PMC 1446942. PMID 16581796.
Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R (July 2006). "Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage". FEBS Letters. 580 (17): 4121–5. doi:10.1016/j.febslet.2006.06.057. PMID 16828750. S2CID 84554520.
Schwartz B, Melnikova VO, Tellez C, Mourad-Zeidan A, Blehm K, Zhao YJ, et al. (June 2007). "Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo". Oncogene. 26 (28): 4049–58. doi:10.1038/sj.onc.1210193. PMID 17224907.

외부 링크

GTF3A+단백질+인간(미국 국립의학도서관 의학 과목 표제(MeSH))

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

이 단백질 관련 기사는 스텁입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000122034 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000016503 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7789179-5] Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, et al. (Jul 1995). "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA". Cytogenetics and Cell Genetics. 70 (3–4): 235–8. doi:10.1159/000134041. PMID 7789179.

[entrez-6] "Entrez Gene: GTF3A general transcription factor IIIA".

[Bruno-et-al-2019-7] Bruno M, Mahgoub M, Macfarlan TS (December 2019). "The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals". Annual Review of Genetics. Annual Reviews. 53 (1): 393–416. doi:10.1146/annurev-genet-112618-043717. PMID 31518518.

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GTF3A

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