C5a수용체

C5AR1
식별자
에일리어스	C5AR1, C5A, C5AR, C5R1, CD88, 보체성분 5a수용체 1, C5a수용체, 보체 C5a수용체 1
외부 ID	OMIM : 113995 MGI : 88232 HomoloGene : 20413 GenCard : C5AR1
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	47,322,066 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	15,993,465 bp
RNA발현패턴
	상단 표시 위치:
	피; ; 단구; ; 골수; ; 골수 세포; ; 뇌하수체; ; 오른쪽 폐; ; 뇌하수체 전엽; ; 치주 섬유; ; 좌폐 상엽; ; 우측 자궁관;
	상단 표시 위치:
	대동맥 판막; ; 상행 대동맥; ; 피; ; 발목; ; 우폐엽; ; 턱밑샘; ; 시신경; ; 피하 지방 조직; ; 백색 지방 조직; ; 칼바리아;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	보체 성분 C5a 결합; 신호 변환기 활성; 보체수용체활성; C5a 수용체 활성을 보충하다; G단백질결합수용체활성;
셀룰러 컴포넌트	막의 적분 성분; 막; 혈장막; 세포의 꼭대기 부분; 혈장막의 적분 성분; 세포 표면; 기저측 혈장막; 세포질 소포; 분비 과립막;
생물학적 과정	뉴런 아포토시스 과정의 음성 조절; 상피세포 증식의 양성 조절; RNA중합효소II에 의한 mRNA 전사; 포스포리파아제C활성화; 호중구 주화성; 혈관신생의 양성 조절; 주화성; 세포방어반응; 리포다당류에 대한 반응; 동물의 장기 재생; 면역 반응; 펩티도글리칸에 대한 반응; ERK1 및 ERK2 캐스케이드 양의 조절; 호중구 주화성 양성 조절; 보체수용체 매개신호경로; 화학적 자극에 대한 감각적 지각; 혈관내피증식인자생산양조절; 후뇌세포증식; 대식세포 화학작용의 양성 조절; 신호 변환; 그램 양성균에 대한 방어 반응; 아포토시스 과정; 보체활성화조절; 염증 반응; 포스포리파아제C활성화G단백질결합수용체신호경로; 호중구 탈과립; 백혈구 이동; 세포주화성; 세포질 칼슘 이온 농도 양성 조절; G단백질결합수용체신호경로; 보체 성분 C5a 신호 경로; 인식; 성상세포활성화조절; 시냅스 전 조직; 아밀로이드 클리어런스 조절; 타우산인산화효소활성조절; 미세아교세포활성화조절;
	출처:아미고 / QuickGO
맞춤법
	728
	12273
	ENSG00000197405
	ENSMUSG000049130
	P21730
	P30993
	NM_001736
	NM_001173550; NM_007577
	NP_001727
	NP_001167021; NP_031603
	위키데이터
인간 보기/편집	마우스 표시/편집

보체 성분 5a 수용체 1(C5AR1) 또는 CD88(Cluster of Differency 88)로도 알려진 C5a 수용체는 C5a에 대한 G 단백질 결합 수용체이다.보체 ^[5]수용체 역할을 합니다.C5a 수용체는 염증 반응, 비만, 발달 및 ^[6]^[7]^[8]암을 조절합니다.

리간드 결합 또는 시그널링 역할을 하는 C5a 수용체 구조 및 그 잔류물.

셀

C5a 수용체는 다음과 ^[9]같이 표현됩니다.

작용제 및 길항제

C5aR에 대한 효과적이고 선택적인 작용제와 길항제들이 ^[10]^[11]^[12]^[13]^[14]^[15]개발되었습니다.

「」를 참조해 주세요.

결합기구용 보완부품 5a

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000197405 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000049130 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology. 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
^ Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, Woodruff TM, Ruitenberg MJ (April 2015). "The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury". The Journal of Neuroscience. 35 (16): 6517–31. doi:10.1523/JNEUROSCI.5218-14.2015. PMC 6605214. PMID 25904802.
^ Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.
^ Markiewski MM, DeAngelis RA, Benencia F, Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, Coukos G, Lambris JD (November 2008). "Modulation of the antitumor immune response by complement". Nature Immunology. 9 (11): 1225–35. doi:10.1038/ni.1655. PMC 2678913. PMID 18820683.
^ Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.
^ Gorman, Declan M.; Li, Xaria X.; Lee, John D.; Fung, Jenny N.; Cui, Cedric S.; Lee, Han Siean; Rolfe, Barbara E.; Woodruff, Trent M.; Clark, Richard J. (2021-11-25). "Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity". Journal of Medicinal Chemistry. 64 (22): 16598–16608. doi:10.1021/acs.jmedchem.1c01174. ISSN 0022-2623. PMID 34762432. S2CID 244040645.
^ Wong AK, Finch AM, Pierens GK, Craik DJ, Taylor SM, Fairlie DP (August 1998). "Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a". Journal of Medicinal Chemistry. 41 (18): 3417–25. doi:10.1021/jm9800651. PMID 9719594.
^ Gong Y, Barbay JK, Buntinx M, Li J, Wauwe JV, Claes C, Lommen GV, Hornby PJ, He W (July 2008). "Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 18 (14): 3852–5. doi:10.1016/j.bmcl.2008.06.059. PMID 18595693.
^ Sumichika H, Sakata K, Sato N, Takeshita S, Ishibuchi S, Nakamura M, Kamahori T, Ehara S, Itoh K, Ohtsuka T, Ohbora T, Mishina T, Komatsu H, Naka Y (December 2002). "Identification of a potent and orally active non-peptide C5a receptor antagonist". The Journal of Biological Chemistry. 277 (51): 49403–7. doi:10.1074/jbc.M209672200. PMID 12384495.
^ Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, Suen JY, Fairlie DP (April 2016). "Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists". Scientific Reports. 6 (1): 24575. Bibcode:2016NatSR...624575S. doi:10.1038/srep24575. PMC 4837355. PMID 27094554.
^ . PMID 10799917. {{cite journal}}: 일기장의 필요성(도움말)을 인용한다.누락 또는 비어 있음(도움말)

추가 정보

Sengeløv H (1996). "Complement receptors in neutrophils". Critical Reviews in Immunology. 15 (2): 107–31. doi:10.1615/critrevimmunol.v15.i2.10. PMID 8573284.
Beil WJ, Schulz M, Wefelmeyer U (July 2000). "Mast cell granule composition and tissue location--a close correlation". Histology and Histopathology. 15 (3): 937–46. PMID 10963136.
Yamamoto T (January 2007). "Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes". Pathology International. 57 (1): 1–11. doi:10.1111/j.1440-1827.2007.02049.x. PMID 17199736. S2CID 22946804.
Bao L, Gerard NP, Eddy RL, Shows TB, Gerard C (June 1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600.
Gerard NP, Gerard C (February 1991). "The chemotactic receptor for human C5a anaphylatoxin". Nature. 349 (6310): 614–7. Bibcode:1991Natur.349..614G. doi:10.1038/349614a0. PMID 1847994. S2CID 4338594.
Boulay F, Mery L, Tardif M, Brouchon L, Vignais P (March 1991). "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells". Biochemistry. 30 (12): 2993–9. doi:10.1021/bi00226a002. PMID 2007135.
Wahl SM, Allen JB, Gartner S, Orenstein JM, Popovic M, Chenoweth DE, Arthur LO, Farrar WL, Wahl LM (May 1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes". Journal of Immunology. 142 (10): 3553–9. PMID 2541200.
Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovsky MM, Eddy SM, Ward PA (September 1994). "C5a-induced expression of P-selectin in endothelial cells". The Journal of Clinical Investigation. 94 (3): 1147–55. doi:10.1172/JCI117430. PMC 295185. PMID 7521884.
Giannini E, Brouchon L, Boulay F (August 1995). "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo". The Journal of Biological Chemistry. 270 (32): 19166–72. doi:10.1074/jbc.270.32.19166. PMID 7642584.
Buhl AM, Osawa S, Johnson GL (August 1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". The Journal of Biological Chemistry. 270 (34): 19828–32. doi:10.1074/jbc.270.34.19828. PMID 7649993.
Wennogle LP, Conder L, Winter C, Braunwalder A, Vlattas S, Kramer R, Cioffi C, Hu SI (July 1994). "Stabilization of C5a receptor--G-protein interactions through ligand binding". Journal of Cellular Biochemistry. 55 (3): 380–8. doi:10.1002/jcb.240550316. PMID 7962171. S2CID 36216040.
Gerard NP, Bao L, Xiao-Ping H, Eddy RL, Shows TB, Gerard C (February 1993). "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene". Biochemistry. 32 (5): 1243–50. doi:10.1021/bi00056a007. PMID 8383526.
Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C (August 1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". The Journal of Biological Chemistry. 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752.
Werfel T, Zwirner J, Oppermann M, Sieber A, Begemann G, Drommer W, Kapp A, Götze O (August 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin". Journal of Immunology. 157 (4): 1729–35. PMID 8759762.
Höpken UE, Lu B, Gerard NP, Gerard C (September 1996). "The C5a chemoattractant receptor mediates mucosal defence to infection". Nature. 383 (6595): 86–9. Bibcode:1996Natur.383...86H. doi:10.1038/383086a0. PMID 8779720. S2CID 4346934.
Chen Z, Zhang X, Gonnella NC, Pellas TC, Boyar WC, Ni F (April 1998). "Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin". The Journal of Biological Chemistry. 273 (17): 10411–9. doi:10.1074/jbc.273.17.10411. PMID 9553099.
Floreani AA, Heires AJ, Welniak LA, Miller-Lindholm A, Clark-Pierce L, Rennard SI, Morgan EL, Sanderson SD (May 1998). "Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke". Journal of Immunology. 160 (10): 5073–81. PMID 9590258.
Ottonello L, Corcione A, Tortolina G, Airoldi I, Albesiano E, Favre A, D'Agostino R, Malavasi F, Pistoia V, Dallegri F (June 1999). "rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues". Journal of Immunology. 162 (11): 6510–7. PMID 10352266.
Kohleisen B, Shumay E, Sutter G, Foerster R, Brack-Werner R, Nuesse M, Erfle V (December 1999). "Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes". AIDS. 13 (17): 2331–41. doi:10.1097/00002030-199912030-00004. PMID 10597774.
Monk PN, Scola AM, Madala P, Fairlie DP (October 2007). "Function, structure and therapeutic potential of complement C5a receptors". British Journal of Pharmacology. 152 (4): 429–48. doi:10.1038/sj.bjp.0707332. PMC 2050825. PMID 17603557.

외부 링크

"Anaphylatoxin Receptors: C5a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
미국 국립 의학 도서관 의학 주제 제목(MeSH)의 C5a+ 수용체
UCSC Genome Browser의 인간 C5AR1 게놈 위치 및 C5AR1 유전자 세부 정보 페이지.
PDBe-KB의 UniProt: P21730(C5a 아나필라톡신 화학요법 수용체 1)에서 사용할 수 있는 모든 구조 정보의 개요.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000197405 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000049130 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8011297-5] Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology. 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.

[6] Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, Woodruff TM, Ruitenberg MJ (April 2015). "The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury". The Journal of Neuroscience. 35 (16): 6517–31. doi:10.1523/JNEUROSCI.5218-14.2015. PMC 6605214. PMID 25904802.

[7] Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.

[8] Markiewski MM, DeAngelis RA, Benencia F, Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, Coukos G, Lambris JD (November 2008). "Modulation of the antitumor immune response by complement". Nature Immunology. 9 (11): 1225–35. doi:10.1038/ni.1655. PMC 2678913. PMID 18820683.

[pmid=_23383423-9] Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.

[10] Gorman, Declan M.; Li, Xaria X.; Lee, John D.; Fung, Jenny N.; Cui, Cedric S.; Lee, Han Siean; Rolfe, Barbara E.; Woodruff, Trent M.; Clark, Richard J. (2021-11-25). "Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity". Journal of Medicinal Chemistry. 64 (22): 16598–16608. doi:10.1021/acs.jmedchem.1c01174. ISSN 0022-2623. PMID 34762432. S2CID 244040645.

[11] Wong AK, Finch AM, Pierens GK, Craik DJ, Taylor SM, Fairlie DP (August 1998). "Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a". Journal of Medicinal Chemistry. 41 (18): 3417–25. doi:10.1021/jm9800651. PMID 9719594.

[12] Gong Y, Barbay JK, Buntinx M, Li J, Wauwe JV, Claes C, Lommen GV, Hornby PJ, He W (July 2008). "Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 18 (14): 3852–5. doi:10.1016/j.bmcl.2008.06.059. PMID 18595693.

[13] Sumichika H, Sakata K, Sato N, Takeshita S, Ishibuchi S, Nakamura M, Kamahori T, Ehara S, Itoh K, Ohtsuka T, Ohbora T, Mishina T, Komatsu H, Naka Y (December 2002). "Identification of a potent and orally active non-peptide C5a receptor antagonist". The Journal of Biological Chemistry. 277 (51): 49403–7. doi:10.1074/jbc.M209672200. PMID 12384495.

[14] Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, Suen JY, Fairlie DP (April 2016). "Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists". Scientific Reports. 6 (1): 24575. Bibcode:2016NatSR...624575S. doi:10.1038/srep24575. PMC 4837355. PMID 27094554.

[15] . PMID 10799917. {{cite journal}}: 일기장의 필요성(도움말)을 인용한다.누락 또는 비어 있음(도움말)

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[2]

[3]

[4]

[5]

[6]

[7]

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[15]

v t 단백질: 분화의 클러스터(분화의 인간 클러스터 목록 참조)
1–50	CD1 교류 1A 1B 1차원 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a) d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDW198 CDW199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDW210 a b CD212 CD213a 1 2 CD217 CD218 (a) b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDW293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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