S1PR5

S1PR5
식별자
별칭	S1PR5, EDG8, Edg-8, S1P5, SPPR-1, SPPR-2, 스핑고신-1-인산염 수용체 5
외부 ID	OMIM: 605146 MGI: 2150641 HomoloGene: 11031 GeneCard: S1PR5
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	10,517,931 bp
유전자 위치(마우스)
쳇.	9번 염색체(쥐)
끝	21,197,739 bp
RNA 표현 패턴
	표현된 상단
	체내구체 팔리두스; ; 흑인의 실체; ; 말뭉치 담낭; ; 질신경의 열등성; ; 본래의 해마; ; 브로드만 구역 46; ; 핏덩어리;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	스핑고신-1-수신기 수용체 활성; G 단백질 결합 수용체 활성; 신호 변환기 활동;
셀룰러 컴포넌트	막의 적분 성분; 플라즈마 막; 막으로 막다;
생물학적 과정	뉴런 분화 조절; 스핑고신-1-수신기 수용체 신호 경로; 신호 전달; G 단백질 결합 수용체 신호 경로;
	출처:아미고 / 퀵고
직교체
	53637
	94226
	ENSG00000180739
	ENSMUSG00000045087
	Q9H228
	Q91X56
	NM_030760; NM_001166215
	NM_053190
	NP_001159687; NP_110387
	NP_444420
	위키다타
인간 보기/편집	마우스 보기/편집

S1PR5로도 알려진 스핑고신-1-인산 수용체 5는 지질 신호 분자 스핑고신 1-인산염(S1P)을 결합하는 G 단백질 결합 수용체를 인코딩하는 인간 유전자다.따라서 이 수용체는 S1P로도₅ 알려져 있다.^[5]

고민자

A-971432^[6]
스핑고신 1인산 수용체 작용제: 특허심사(2010-2012)^[7]

참고 항목

리소포스포리피드 수용체

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000180739 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000045087 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5".
^ Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK (Nov 2015). "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders". Journal of Medicinal Chemistry. 58 (23): 9154–70. doi:10.1021/acs.jmedchem.5b00928. PMID 26509640.
^ Roberts E, Guerrero M, Urbano M, Rosen H (Jul 2013). "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)". Expert Opin Ther Pat. 23 (7): 817–41. doi:10.1517/13543776.2013.783022. PMID 23541049. S2CID 24421259.

추가 읽기

Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR (May 2000). "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8". The Journal of Biological Chemistry. 275 (19): 14281–6. doi:10.1074/jbc.275.19.14281. PMID 10799507.
Malek RL, Toman RE, Edsall LC, Wong S, Chiu J, Letterle CA, Van Brocklyn JR, Milstien S, Spiegel S, Lee NH (Feb 2001). "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors". The Journal of Biological Chemistry. 276 (8): 5692–9. doi:10.1074/jbc.M003964200. PMID 11069896.
Hla T (Apr 2001). "Sphingosine 1-phosphate receptors". Prostaglandins. 64 (1–4): 135–142. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101.
Im DS, Clemens J, Macdonald TL, Lynch KR (Nov 2001). "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors". Biochemistry. 40 (46): 14053–60. doi:10.1021/bi011606i. PMID 11705398.
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Niedernberg A, Scherer CR, Busch AE, Kostenis E (Oct 2002). "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists". Biochemical Pharmacology. 64 (8): 1243–50. doi:10.1016/S0006-2952(02)01289-3. PMID 12234605.
Kothapalli R, Kusmartseva I, Loughran TP (Dec 2002). "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1579 (2–3): 117–23. doi:10.1016/S0167-4781(02)00529-8. PMID 12427546.
Vogler R, Sauer B, Kim DS, Schäfer-Korting M, Kleuser B (Apr 2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". The Journal of Investigative Dermatology. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
Ulfig N, Briese M (2005). "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers". Acta Histochemica. 106 (5): 373–8. doi:10.1016/j.acthis.2004.08.002. PMID 15530552.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Van der Kam E, Turner S, van Bergeij J, Mueller R, Mezler M, Bespalov A, Hobson A, Harris CM, Rendenbach-Mueller B, Schoemaker H (Jun 2014). "The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease". Alzheimer's & Dementia. 10: P281. doi:10.1016/j.jalz.2014.07.153. S2CID 54386805.
Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J (Oct 2009). "T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow". J Exp Med. 206 (11): 2469–81. doi:10.1084/jem.20090525. PMC 2768857. PMID 19808259.

외부 링크

"Lysophospholipid Receptors: S₁P₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
미국 국립 의학 도서관의 Lysophospholipid+수용체(MesH)

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

이 투과성 수용체 관련 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000180739 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000045087 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5".

[6] Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK (Nov 2015). "Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders". Journal of Medicinal Chemistry. 58 (23): 9154–70. doi:10.1021/acs.jmedchem.5b00928. PMID 26509640.

[7] Roberts E, Guerrero M, Urbano M, Rosen H (Jul 2013). "Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)". Expert Opin Ther Pat. 23 (7): 817–41. doi:10.1517/13543776.2013.783022. PMID 23541049. S2CID 24421259.

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S1PR5

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참고 항목

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