뉴로펩타이드S수용체

NPSR1
식별자
에일리어스	NPSR1, ASRT2, GPR154, GPRA, NPSR, PGR14, VRR1, 뉴로펩타이드S수용체1
외부 ID	OMIM : 608595 MGI : 2441738 HomoloGene : 45515 GenCard : NPSR1
유전자 위치(인간)
크르.	7번 염색체(인간)
끝.	34,878,332 bp
유전자 위치(마우스)
크르.	9번 염색체(쥐)
끝.	24,227,694 bp
RNA발현패턴
	상단 표시 위치:
	신경절 융기; ; 시상하부; ; 전전두피질; ; 브로드만 9구역; ; 직장; ; 태반; ; 측두엽; ; 편도체; ; 고유 해마; ; 흑색 실체;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	G단백질결합수용체활성; 바소프레신수용체활성; 신호 변환기 활성; 신경펩티드수용체활성;
셀룰러 컴포넌트	세포질; 막의 적분 성분; 혈장막; 혈장막의 적분 성분; 막;
생물학적 과정	세포에 격리된 칼슘 이온 방출의 양성 조절; 신경펩티드신호경로; GO:0072468 신호 변환; G단백질결합수용체신호경로;
	출처:아미고 / QuickGO
맞춤법
	387129
	319239
	ENSG00000187258
	ENSMUSG000043659
	Q6W5P4
	Q8BZP8
	NM_207173; NM_001300933; NM_001300934; NM_001300935; NM_207172
	NM_175678
	NP_001287862; NP_001287863; NP_001287864; NP_997055; NP_997056
	NP_783609
	위키데이터
인간 보기/편집	마우스 표시/편집

뉴로펩타이드S수용체(NPSR)는 뉴로펩타이드S(NPS)^[6]와 결합하는 통합막단백질의^[5] G단백질 결합수용체 슈퍼패밀리의 구성원이다.그것은 내인성 배위자로 신경펩타이드 S가 발견되기 전까지 고아 수용체였던 GPR154였다.호흡상피 섬모세포 및 기관지 평활근세포에서 이 유전자의 발현 증가는 천식과 관련이 있다.이 유전자는 G단백질결합수용체 1족으로 혈장막 단백질을 암호화한다.이 유전자의 돌연변이도 이 ^[7]질병과 관련이 있다.

임상적 의의

CNS에서 NPS에 의한 NPSR의 활성화는 각성 ^[8]^[9]및 항불안제성 효과를 촉진한다.

또한 NPSR의 돌연변이는 천식(rs3249801, A107I)^[10]에 대한 민감성과 관련이 있다.따라서 NPSR은 GPRA(천식 감수성을 위한 G 단백질 결합 수용체)라고도 불린다.기도상피에서의 NPSR 활성화는 ^[11]천식의 병인에 관여하는 매트릭스 금속단백질가수분해효소의 상향조절을 포함한 많은 효과를 가진다.NPS에 의한 NPSR의 활성화는 위장 운동성과 점막 투과성에 동시에 영향을 미치는 것으로 나타났다.NPSR1의 비정상적인 신호 전달과 상향 조절은 위장 기능 및 염증 ^[12]반응의 국소 메커니즘에 의해 운동 장애와 과투과성을 잠재적으로 악화시킬 수 있다.

수용체를 NPS에 더 민감하게 만드는 매우 드문 NPSR 돌연변이 Y206H는 정상 가족보다 수면 시간이 더 적게 필요한 인간 가족에서 발견됩니다.그것은 유전자 변형 생쥐에게도 비슷한 영향을 미치며,^[13] 수면 부족으로 인한 기억 장애에 저항하게 만든다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000187258 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000043659 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
^ Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Räisänen-Sokolowski A, Laitinen A, Laitinen LA, Kere J, Laitinen T (Sep 2005). "Characterization of GPRA, a novel G protein-coupled receptor related to asthma". American Journal of Respiratory Cell and Molecular Biology. 33 (3): 262–70. doi:10.1165/rcmb.2004-0405OC. PMID 15947423.
^ "Entrez Gene: NPSR1 neuropeptide S receptor 1".
^ Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O (Aug 2004). "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects". Neuron. 43 (4): 487–97. doi:10.1016/j.neuron.2004.08.005. PMID 15312648. S2CID 15601843.
^ Okamura N, Reinscheid RK (Aug 2007). "Neuropeptide S: a novel modulator of stress and arousal". Stress. 10 (3): 221–6. doi:10.1080/10253890701248673. PMID 17613937. S2CID 39068808.
^ Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Mäkelä S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullstén H, Leino M, Alenius H, Petäys T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J (Apr 2004). "Characterization of a common susceptibility locus for asthma-related traits". Science. 304 (5668): 300–4. doi:10.1126/science.1090010. PMID 15073379. S2CID 9149671.
^ Vendelin J, Bruce S, Holopainen P, Pulkkinen V, Rytilä P, Pirskanen A, Rehn M, Laitinen T, Laitinen LA, Haahtela T, Saarialho-Kere U, Laitinen A, Kere J (Oct 2006). "Downstream target genes of the neuropeptide S-NPSR1 pathway". Human Molecular Genetics. 15 (19): 2923–35. doi:10.1093/hmg/ddl234. PMID 16926187.
^ Wan Saudi WS, Halim MA, Rudholm-Feldreich T, Gillberg L, Rosenqvist E, Tengholm A, Sundbom M, Karlbom U, Näslund E, Webb DL, Sjöblom M, Hellström PM (Oct 2015). "Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide". Am J Physiol Gastrointest Liver Physiol. 309 (9): G625-34. doi:10.1152/ajpgi.00104.2015. PMID 26206857.
^ Xing L, Shi G, Mostovoy Y, Gentry NW, Fan Z, McMahon TB, et al. (16 October 2019). "Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation" (PDF). Science Translational Medicine. 11 (514): eaax2014. doi:10.1126/scitranslmed.aax2014. PMC 7587149. PMID 31619542. S2CID 204756335.

추가 정보

Malerba G, Pignatti PF (2005). "A review of asthma genetics: gene expression studies and recent candidates". Journal of Applied Genetics. 46 (1): 93–104. PMID 15741670.
Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Gupte J, Cutler G, Chen JL, Tian H (Feb 2004). "Elucidation of signaling properties of vasopressin receptor-related receptor 1 by using the chimeric receptor approach". Proceedings of the National Academy of Sciences of the United States of America. 101 (6): 1508–13. doi:10.1073/pnas.0308250100. PMC 341764. PMID 14757815.
Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Mäkelä S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullstén H, Leino M, Alenius H, Petäys T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J (Apr 2004). "Characterization of a common susceptibility locus for asthma-related traits". Science. 304 (5668): 300–4. doi:10.1126/science.1090010. PMID 15073379. S2CID 9149671.
Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O (Aug 2004). "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects". Neuron. 43 (4): 487–97. doi:10.1016/j.neuron.2004.08.005. PMID 15312648. S2CID 15601843.
Melén E, Bruce S, Doekes G, Kabesch M, Laitinen T, Lauener R, Lindgren CM, Riedler J, Scheynius A, van Hage-Hamsten M, Kere J, Pershagen G, Wickman M, Nyberg F (May 2005). "Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma". American Journal of Respiratory and Critical Care Medicine. 171 (10): 1089–95. doi:10.1164/rccm.200410-1317OC. PMID 15710598.
Kormann MS, Carr D, Klopp N, Illig T, Leupold W, Fritzsch C, Weiland SK, von Mutius E, Kabesch M (Jun 2005). "G-Protein-coupled receptor polymorphisms are associated with asthma in a large German population". American Journal of Respiratory and Critical Care Medicine. 171 (12): 1358–62. doi:10.1164/rccm.200410-1312OC. PMID 15764725.
Gloriam DE, Schiöth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta (BBA) - General Subjects. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.
Postma DS, Koppelman GH (Jun 2005). "Confirmation of GPRA: a putative drug target for asthma". American Journal of Respiratory and Critical Care Medicine. 171 (12): 1323–4. doi:10.1164/rccm.2503006. PMID 15941840.
Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Räisänen-Sokolowski A, Laitinen A, Laitinen LA, Kere J, Laitinen T (Sep 2005). "Characterization of GPRA, a novel G protein-coupled receptor related to asthma". American Journal of Respiratory Cell and Molecular Biology. 33 (3): 262–70. doi:10.1165/rcmb.2004-0405OC. PMID 15947423.
Söderhäll C, Marenholz I, Nickel R, Grüber C, Kehrt R, Rohde K, Griffioen RW, Meglio P, Tarani L, Gustafsson D, Hoffmann U, Gerstner B, Müller S, Wahn U, Lee YA (Jul 2005). "Lack of association of the G protein-coupled receptor for asthma susceptibility gene with atopic dermatitis". The Journal of Allergy and Clinical Immunology. 116 (1): 220–1. doi:10.1016/j.jaci.2005.03.002. PMID 15990798.
Veal CD, Reynolds NJ, Meggitt SJ, Allen MH, Lindgren CM, Kere J, Trembath RC, Barker JN (Aug 2005). "Absence of association between asthma and high serum immunoglobulin E associated GPRA haplotypes and adult atopic dermatitis". The Journal of Investigative Dermatology. 125 (2): 399–401. doi:10.1111/j.0022-202X.2005.23828.x. PMID 16098057.
Feng Y, Hong X, Wang L, Jiang S, Chen C, Wang B, Yang J, Fang Z, Zang T, Xu X, Xu X (Mar 2006). "G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population". The Journal of Allergy and Clinical Immunology. 117 (3): 612–7. doi:10.1016/j.jaci.2005.11.045. PMID 16522461.
Bernier V, Stocco R, Bogusky MJ, Joyce JG, Parachoniak C, Grenier K, Arget M, Mathieu MC, O'Neill GP, Slipetz D, Crackower MA, Tan CM, Therien AG (Aug 2006). "Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I". The Journal of Biological Chemistry. 281 (34): 24704–12. doi:10.1074/jbc.M603691200. PMID 16790440.
Allen IC, Pace AJ, Jania LA, Ledford JG, Latour AM, Snouwaert JN, Bernier V, Stocco R, Therien AG, Koller BH (Nov 2006). "Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (5): L1005-17. doi:10.1152/ajplung.00174.2006. PMID 16829631.
Vendelin J, Bruce S, Holopainen P, Pulkkinen V, Rytilä P, Pirskanen A, Rehn M, Laitinen T, Laitinen LA, Haahtela T, Saarialho-Kere U, Laitinen A, Kere J (Oct 2006). "Downstream target genes of the neuropeptide S-NPSR1 pathway". Human Molecular Genetics. 15 (19): 2923–35. doi:10.1093/hmg/ddl234. PMID 16926187.
Pulkkinen V, Haataja R, Hannelius U, Helve O, Pitkänen OM, Karikoski R, Rehn M, Marttila R, Lindgren CM, Hästbacka J, Andersson S, Kere J, Hallman M, Laitinen T (2007). "G protein-coupled receptor for asthma susceptibility associates with respiratory distress syndrome". Annals of Medicine. 38 (5): 357–66. doi:10.1080/07853890600756453. PMID 16938805. S2CID 10090669.

외부 링크

"Neuropeptide S Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
NPSR1+단백질+인간(미국 국립의학도서관 의학 과목 표제(MeSH))

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000187258 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000043659 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12679517-5] Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.

[pmid15947423-6] Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Räisänen-Sokolowski A, Laitinen A, Laitinen LA, Kere J, Laitinen T (Sep 2005). "Characterization of GPRA, a novel G protein-coupled receptor related to asthma". American Journal of Respiratory Cell and Molecular Biology. 33 (3): 262–70. doi:10.1165/rcmb.2004-0405OC. PMID 15947423.

[entrez-7] "Entrez Gene: NPSR1 neuropeptide S receptor 1".

[pmid15312648-8] Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O (Aug 2004). "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects". Neuron. 43 (4): 487–97. doi:10.1016/j.neuron.2004.08.005. PMID 15312648. S2CID 15601843.

[pmid17613937-9] Okamura N, Reinscheid RK (Aug 2007). "Neuropeptide S: a novel modulator of stress and arousal". Stress. 10 (3): 221–6. doi:10.1080/10253890701248673. PMID 17613937. S2CID 39068808.

[pmid15073379-10] Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Mäkelä S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullstén H, Leino M, Alenius H, Petäys T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J (Apr 2004). "Characterization of a common susceptibility locus for asthma-related traits". Science. 304 (5668): 300–4. doi:10.1126/science.1090010. PMID 15073379. S2CID 9149671.

[pmid16926187-11] Vendelin J, Bruce S, Holopainen P, Pulkkinen V, Rytilä P, Pirskanen A, Rehn M, Laitinen T, Laitinen LA, Haahtela T, Saarialho-Kere U, Laitinen A, Kere J (Oct 2006). "Downstream target genes of the neuropeptide S-NPSR1 pathway". Human Molecular Genetics. 15 (19): 2923–35. doi:10.1093/hmg/ddl234. PMID 16926187.

[pmid26206857-12] Wan Saudi WS, Halim MA, Rudholm-Feldreich T, Gillberg L, Rosenqvist E, Tengholm A, Sundbom M, Karlbom U, Näslund E, Webb DL, Sjöblom M, Hellström PM (Oct 2015). "Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide". Am J Physiol Gastrointest Liver Physiol. 309 (9): G625-34. doi:10.1152/ajpgi.00104.2015. PMID 26206857.

[13] Xing L, Shi G, Mostovoy Y, Gentry NW, Fan Z, McMahon TB, et al. (16 October 2019). "Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation" (PDF). Science Translational Medicine. 11 (514): eaax2014. doi:10.1126/scitranslmed.aax2014. PMC 7587149. PMID 31619542. S2CID 204756335.

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뉴로펩타이드S수용체

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