개연성 G단백 결합 수용체 37 은 인간에서 GPR37 유전자 에 의해 암호화된 단백질 이다.[5] [6]
상호작용 GPR37은 HSPA1A [7] 파킨(ligase) 과 상호작용 하는 것으로 나타났다. [7] [8] GPR37은 프로사포신 의 수용체다. 이전에는 히드라 에서 발견된 신경펩타이드 인 머리 활성제 의 수용체라고 생각되었지만 포유류에서 머리 활성체에 대한 초기 보고는 확인되지 않았다.[9]
GPR37 신호는 생쥐의 후각적 정박 세포 (OEC)와 고나도트로핀 방출 호르몬 (GnRH) 세포의 이동을 변조하는 것으로 나타났다.[10]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000170775 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000039904 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics . 45 (1): 68–77. doi :10.1006/geno.1997.4900 . PMID 9339362 . ^ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)" .^ a b Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity" . Molecular Cell . 10 (1): 55–67. doi :10.1016/S1097-2765(02)00583-X PMID 12150907 . ^ Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin" . Cell . 105 (7): 891–902. doi :10.1016/S0092-8674(01)00407-X PMID 11439185 . S2CID 721363 . ^ Meyer, Rebecca C.; Giddens, Michelle M.; Schaefer, Stacy A.; Hall, Randy A. (4 June 2013). "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin" . Proceedings of the National Academy of Sciences . 110 (23): 9529–34. Bibcode :2013PNAS..110.9529M . doi :10.1073/pnas.1219004110 PMC 3677493 PMID 23690594 . ^ Saadi H, Shan Y, Wray S (2019). "GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice" . Frontiers in Cellular Neuroscience . 13 : 200. doi :10.3389/fncel.2019.00200 PMC 6521704 PMID 31143101 .
추가 읽기 Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain". Biochemical and Biophysical Research Communications . 233 (2): 559–67. doi :10.1006/bbrc.1997.6408 . PMID 9144577 . Donohue PJ, Shapira H, Mantey SA, Hampton LL, Jensen RT, Battey JF (1998). "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system" . Molecular Brain Research . 54 (1): 152–60. doi :10.1016/S0169-328X(97)00336-7 . PMID 9526070 . Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin" . Cell . 105 (7): 891–902. doi :10.1016/S0092-8674(01)00407-X PMID 11439185 . S2CID 721363 . Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity" . Molecular Cell . 10 (1): 55–67. doi :10.1016/S1097-2765(02)00583-X PMID 12150907 . Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B (2003). "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila" . Neuron . 37 (6): 911–24. doi :10.1016/S0896-6273(03)00143-0 PMID 12670421 . S2CID 8430695 . Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death" . Journal of Biological Chemistry . 278 (51): 51901–10. doi :10.1074/jbc.M309655200 PMID 14532270 . Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y (2006). "Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress" . Journal of Neurochemistry . 97 (5): 1259–68. doi :10.1111/j.1471-4159.2006.03782.x PMID 16539653 . S2CID 24540976 . Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y (2006). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin" (PDF) . Journal of Neurochemistry . 99 (6): 1456–69. doi :10.1111/j.1471-4159.2006.04155.x . hdl :2115/17141 PMID 17059562 . S2CID 6256027 .
