KIR3DL1
KIR3DL1
킬러 세포 면역글로불린 유사 수용체 3DL1은 인간 내 KIR3DL1 유전자에 의해 암호화된 단백질이다.[3][4][5]
킬러 세포 면역글로불린 유사 수용체(KIRs)는 자연 킬러 세포와 T 세포의 서브셋에 의해 발현되는 트랜섬브레인 당단백질이다.KIR 유전자는 다형성 및 고동맥성으로 1Mb 백혈구 면역글로불린 유사 수용체 복합체(LRC) 내 19q13.4 염색체의 성단에서 발견된다.여러 "프레임워크" 유전자가 모든 하플라타입(KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2)에서 발견되기는 하지만 KIR 유전자 군집의 유전자 함량은 하플라타입에 따라 다르다.KIR 단백질은 세포외 면역글로불린 영역 수(2D 또는 3D)와 세포질 영역이 긴지 짧은지(S)로 분류된다.면역 티로신 기반 억제 모티브(ITIM)를 통해 리간드 결합 시 긴 세포질 영역 변환 억제 신호를 가진 KIR 단백질은 ITIM 모티브가 부족한 반면, 짧은 세포질 영역을 가진 KIR 단백질은 대신 TYRO 단백질 티로신 키나제 결합 단백질과 결합하여 변환 활성 신호를 만든다.몇몇 KIR 단백질의 리간드는 HLA 등급 I 분자의 하위 집합이므로, KIR 단백질은 면역 반응의 조절에 중요한 역할을 한다고 생각된다.[5]
참고 항목
참조
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추가 읽기
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이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.
