G 단백질 결합 수용체 112는 ADGRG4 유전자 에 의해 인코딩된 단백질 이다.[5] [6] GPR112는 접착 GPCR 계열의 일원이다.[7] [8] 접착성 GPCR은 종종 GPCR-자극성분해(Gain) 영역으로 알려진 도메인을 통해 TM7 영역에 연결된 N단자외 단백질 모듈을 보유한 확장된 세포외 영역이 특징이다.[9]
GPR112는 인간 장로마핀 세포와[10] [11] GPR112의 N-단자 파편(NTF)에는 펜트락신(PTX) 유사 모듈이 포함되어 있다.[11] GPR112 유전자 발현이 신경내분비암 세포의 표식자로 확인됐다.[10]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000156920 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000053852 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: GPR112 G protein-coupled receptor 112" .^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors" . Pharmacological Reviews . 67 (2): 338–67. doi :10.1124/pr.114.009647 . PMC 4394687 PMID 25713288 . ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Berlin: Springer. ISBN 1-4419-7912-3 ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling . 6 (276): re3. doi :10.1126/scisignal.2003825 . PMID 23695165 . ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis" . The EMBO Journal . 31 (6): 1364–78. doi :10.1038/emboj.2012.26 . PMC 3321182 PMID 22333914 . ^ a b Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V (Feb 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas" . Modern Pathology . 22 (2): 261–72. doi :10.1038/modpathol.2008.174 PMID 18953328 . ^ a b Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors" . Pharmacological Reviews . 67 (2): 338–67. doi :10.1124/pr.114.009647 . PMC 4394687 PMID 25713288 . 외부 링크
