EMR1

ADGRE1
식별자
별칭	ADGRE1, TM7LN3, EMR1, 접착 G 단백질 결합 수용체 E1
외부 ID	OMIM: 600493 MGI: 106912 HomoloGene: 1493 GeneCard: ADGRE1
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	6,940,459 bp
유전자 위치(마우스)
쳇.	17번 염색체(쥐)
끝	57,790,527 bp
RNA 표현 패턴
	표현된 상단
	핏덩어리; ; 비장의; ; 골수; ; 맹장; ; 폐를 끼치다; ; 고환; ; 십이지장; ; 비뇨기 방광; ; 오른쪽 폐; ; 소장;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	칼슘 이온 결합; G 단백질 결합 수용체 활성; 투과 브레인 신호 수용체 활성; 신호 변환기 활동;
셀룰러 컴포넌트	막의 적분 성분; 플라즈마 막; 플라스마 막의 적분 성분; 막으로 막다; 플라즈마 막의 외부 면; 세포 주변부; 세포내 해부학적 구조;
생물학적 과정	G 단백질 결합 수용체 신호 경로; 세포표면 수용체 신호 경로; 세포 접착; 적응 면역 반응; 신호 전달; 면역 체계 과정; 아데닐레이트 사이클라아제 활성화 G 단백질 결합 수용체 신호 경로;
	출처:아미고 / 퀵고
직교체
	2015
	13733
	ENSG00000174837
	ENSMUSG00000004730
	Q14246
	Q61549
	NM_001256252; NM_001256253; NM_001256254; NM_001256255; NM_001974
	NM_010130; NM_001355722; NM_001355723
	NP_001243181; NP_001243182; NP_001243183; NP_001243184; NP_001965
	NP_034260; NP_001342651; NP_001342652
	위키다타
인간 보기/편집	마우스 보기/편집

EGF와 같은 모듈형 뮤신 같은 호르몬 수용체 1로 알려진 F4/80은 ADGRE1 유전자에 의해 인코딩된 단백질이다.^[5]^[6]^[7]^[8]^[9]EMR1은 접착 GPCR 계열의 구성원이다.^[10]^[11]접착성 GPCR은 종종 GPCR-자극성분해(Gain) 영역으로 알려진 도메인을 통해 TM7 영역에 연결된 N단자외 단백질 모듈을 보유한 확장된 세포외 영역이 특징이다.^[12]

인간의 EMR1 표현은 eosinophils로 제한되며 이러한 세포의 특정 표식이다.^[13]EMR1, F4/80의 뮤린 호몰로그는 머린 대식세포 집단의 잘 알려져 있고 널리 사용되는 표식이다.^[14]EMR1의 N-단자 조각(NTF)은 인간에 4-6개의 표피 성장인자 유사(EGF 유사) 도메인과 마우스에는 4-7개의 EGF 유사 도메인을 포함하고 있다.^[15]

함수

린 외 연구진은 F4/80 녹아웃 마우스를 활용하여 F4/80이 조직 대식세포 개발에 필요한 것이 아니라 주변 허용오차에 필요한 효율적인 CD8⁺ 규제 T 세포의 유도에 필요한 것임을 보여주었다.^[16]

임상적 유의성

Legrand 외 연구진은 EMR1이 아푸코실화 항체를 사용함으로써 어시노필 장애에서 이들 세포의 고갈에 대한 치료목표 역할을 할 수 있음을 입증했다.^[17]

참고 항목

EGF 모듈 함유 뮤신 유사 호르몬 수용체

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000174837 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000004730 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
^ McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–80. doi:10.1002/jlb.63.3.271. PMID 9500513. S2CID 6497890.
^ "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".
^ Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. hdl:1765/71089. PMID 8083537.
^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
^ Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ (October 2007). "EMR1, the human homolog of F4/80, is an eosinophil-specific receptor". European Journal of Immunology. 37 (10): 2797–802. doi:10.1002/eji.200737553. PMID 17823986.
^ Austyn JM, Gordon S (October 1981). "F4/80, a monoclonal antibody directed specifically against the mouse macrophage". European Journal of Immunology. 11 (10): 805–15. doi:10.1002/eji.1830111013. PMID 7308288.
^ Gordon S, Hamann J, Lin HH, Stacey M (September 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799.
^ Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J (May 2005). "The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance". The Journal of Experimental Medicine. 201 (10): 1615–25. doi:10.1084/jem.20042307. PMC 2212925. PMID 15883173.
^ Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD (May 2014). "The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders". The Journal of Allergy and Clinical Immunology. 133 (5): 1439–47, 1447.e1–8. doi:10.1016/j.jaci.2013.11.041. PMC 4113341. PMID 24530099.

외부 링크

GPCR 컨소시엄

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000174837 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000004730 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7601460-5] Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.

[pmid9500513-6] McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–80. doi:10.1002/jlb.63.3.271. PMID 9500513. S2CID 6497890.

[entrez-7] "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".

[pmid8083537-8] Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. hdl:1765/71089. PMID 8083537.

[9] Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-10] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[11] Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

[pmid22333914-12] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[13] Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ (October 2007). "EMR1, the human homolog of F4/80, is an eosinophil-specific receptor". European Journal of Immunology. 37 (10): 2797–802. doi:10.1002/eji.200737553. PMID 17823986.

[14] Austyn JM, Gordon S (October 1981). "F4/80, a monoclonal antibody directed specifically against the mouse macrophage". European Journal of Immunology. 11 (10): 805–15. doi:10.1002/eji.1830111013. PMID 7308288.

[15] Gordon S, Hamann J, Lin HH, Stacey M (September 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799.

[16] Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J (May 2005). "The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance". The Journal of Experimental Medicine. 201 (10): 1615–25. doi:10.1084/jem.20042307. PMC 2212925. PMID 15883173.

[17] Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD (May 2014). "The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders". The Journal of Allergy and Clinical Immunology. 133 (5): 1439–47, 1447.e1–8. doi:10.1016/j.jaci.2013.11.041. PMC 4113341. PMID 24530099.

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Search

EMR1

네임스페이스

더

목차

함수

임상적 유의성

참고 항목

참조

외부 링크