DDR1
DDR1
DDR1 또는 CD167a(분화 167a 클러스터)라고도 알려진 디스코이드 도메인 수용체 제품군인 멤버 1은 인간의 유전자다.[5]
함수
수용체 Tyrosine kinases(RTKs)는 세포의 미세 환경과의 통신에 핵심적인 역할을 한다.이 분자들은 세포 성장, 분화, 신진대사의 조절에 관여한다.이 유전자가 인코딩한 단백질은 정상적이고 변형된 상피세포에서 광범위하게 발현되며 다양한 종류의 콜라겐에 의해 활성화되는 RTK이다.이 단백질은 세포외 영역에 있는 디스코스텔륨 단백질 디스코이드인 I의 호몰로지 영역을 가진 티로신 키나아제 수용체 하위군에 속한다.그것의 자기인산화는 지금까지 시험한 모든 콜라겐에 의해 달성된다(타입 I to type VI).긴밀한 가족 구성원은 DDR2 단백질이다.[6]상황 연구와 북부-블롯 분석에서 이 암호화된 단백질의 발현이 특히 신장, 폐, 위장, 뇌에서 상피 세포로 제한된다는 것을 보여주었다.게다가, 이 단백질은 유방, 난소, 식도, 소아 뇌로부터 오는 몇몇 인간 종양에서 현저하게 과다하게 발현된다.이 유전자는 6p21.3 염색체에 여러 HLA 등급 I 유전자와 인접해 있다.이 유전자의 대체적인 스플라이싱은 여러 가지 대본을 변형시키는 결과를 낳는다.[5]
참조
- ^ a b c ENSG00000137332, ENSG00000229767, ENSG00000230456, ENSG00000234078, ENSG00000204580, ENSG00000223680 GRCh38: Ensembl release 89: ENSG00000215522, ENSG00000137332, ENSG00000229767, ENSG00000230456, ENSG00000234078, ENSG00000204580, ENSG00000223680 - Ensembl, May 2017
- ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000003534 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: DDR1 discoidin domain receptor family, member 1".
- ^ Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R (Mar 2013). "Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling". The Journal of Biological Chemistry. 288 (11): 7430–7. doi:10.1074/jbc.R112.444158. PMC 3597784. PMID 23335507.
추가 읽기
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- Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD (Dec 1997). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Molecular Cell. 1 (1): 25–34. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900.
- Vogel W, Brakebusch C, Fässler R, Alves F, Ruggiero F, Pawson T (Feb 2000). "Discoidin domain receptor 1 is activated independently of beta(1) integrin". The Journal of Biological Chemistry. 275 (8): 5779–84. doi:10.1074/jbc.275.8.5779. PMID 10681566.
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- Weiner HL, Huang H, Zagzag D, Boyce H, Lichtenbaum R, Ziff EB (Dec 2000). "Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors". Neurosurgery. 47 (6): 1400–9. doi:10.1097/00006123-200012000-00028. PMID 11126911. S2CID 2299503.
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이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.
