C3a수용체

C3AR1
식별자
에일리어스	C3AR1, AZ3B, C3AR, HNFAG09, 보체 성분 3a 수용체 1, 보체 C3a 수용체 1
외부 ID	OMIM : 605246 MGI : 1097680 HomoloGene : 2992 GenCard : C3AR1
유전자 위치(인간)
크르.	12번 염색체(인간)
끝.	8,066,359 bp
유전자 위치(마우스)
크르.	6번 염색체(쥐)
끝.	122,833,120 bp
RNA발현패턴
	상단 표시 위치:
	단구; ; 결석골; ; 양수; ; 골수; ; 피; ; 부록; ; 폐하엽; ; 골수 세포; ; 천측두동맥; ; 우심실;
	상단 표시 위치:
	칼바리아; ; 발목 관절; ; 발목; ; 내경동맥; ; 외경동맥; ; 좌골 신경; ; 백색 지방 조직; ; 경동맥체; ; 우심실; ; 대동맥 판막;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	신호 변환기 활성; 보체수용체활성; C3a 수용체 활성을 보충하다; G단백질결합수용체활성;
셀룰러 컴포넌트	막의 적분 성분; 혈장막의 적분 성분; 막; 혈장막; 아즈로필과립막; 특이 과립막;
생물학적 과정	혈액 순환; 신호 변환; 주화성; 호중구 주화성 양성 조절; 혈관신생의 양성 조절; 대식세포 화학작용의 양성 조절; 염증 반응; 혈관내피증식인자생산양조절; G단백질결합수용체신호경로; 보체활성화조절; 포스포리파아제C활성화G단백질결합수용체신호경로; 호중구 탈과립; 백혈구 이동; 세포주화성; 보체수용체 매개신호경로; 세포질 칼슘 이온 농도 양성 조절; 포스포리파아제C활성화G단백질결합신호경로에 관여하는 세포질칼슘이온농도의 양성조절;
	출처:아미고 / QuickGO
맞춤법
	719
	12267
	ENSG00000171860
	ENSMUSG000040552
	문제 16581
	O09047
	NM_004054; NM_001326475; NM_001326477
	NM_009779
	NP_001313404; NP_001313406; NP_004045
	NP_033909
	위키데이터
인간 보기/편집	마우스 표시/편집

보체 성분 3a 수용체 1(C3AR1)이라고도 하는 C3a 수용체는 보체 ^[5]^[6]시스템에 관여하는 G 단백질 결합 수용체 단백질이다.

이 수용체는 보체 성분인 C3a에 결합하지만, 이 수용체가 또한 덜 작은 포유류에서 C4a와 결합한다는 제한된 증거가 있지만,^[7] 이것은 아직 사람에게서 사실로 증명되지 않았다.C3a 수용체는 면역,^[8] 관절염, 식이요법으로 인한^[9] 비만 및 암을^[10] 조절한다.

작용제 및 길항제

C3aR에 대한 효과적이고 선택적인^[11] 작용제와 길항제들이^[12] 발견되었다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000171860 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000040552 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
^ Ali H, Panettieri RA (February 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research. 6: 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.
^ Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.
^ Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt.12405. PMC 3809075. PMID 24033923.
^ Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.
^ Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4): 747–58. doi:10.1002/cam4.241. PMC 4303144. PMID 24711204.
^ Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP (2013). "Downsizing a human inflammatory protein to a small molecule with equal potency and functionality". Nature Communications. 4: 2802. doi:10.1038/ncomms3802. PMID 24257095.
^ Reid RC, Yau MK, Singh R, Lim J, Fairlie DP (August 2014). "Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides". Journal of the American Chemical Society. 136 (34): 11914–7. doi:10.1021/ja506518t. PMID 25102224.

추가 정보

Sim RB, Laich A (October 2000). "Serine proteases of the complement system". Biochemical Society Transactions. 28 (5): 545–50. doi:10.1042/bst0280545. PMID 11044372.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C (August 1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". The Journal of Biological Chemistry. 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752.
Crass T, Raffetseder U, Martin U, Grove M, Klos A, Köhl J, Bautsch W (August 1996). "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells". European Journal of Immunology. 26 (8): 1944–50. doi:10.1002/eji.1830260840. PMID 8765043. S2CID 24586216.
Ames RS, Nuthulaganti P, Kumar C (October 1996). "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins". FEBS Letters. 395 (2–3): 157–9. doi:10.1016/0014-5793(96)01018-6. PMID 8898085. S2CID 39187651.
Martin U, Bock D, Arseniev L, Tornetta MA, Ames RS, Bautsch W, Köhl J, Ganser A, Klos A (July 1997). "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes". The Journal of Experimental Medicine. 186 (2): 199–207. doi:10.1084/jem.186.2.199. PMC 2198980. PMID 9221749.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hollmann TJ, Haviland DL, Kildsgaard J, Watts K, Wetsel RA (February 1998). "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene". Molecular Immunology. 35 (3): 137–48. doi:10.1016/S0161-5890(98)00021-2. PMID 9694514.
Lienenklaus S, Ames RS, Tornetta MA, Sarau HM, Foley JJ, Crass T, Sohns B, Raffetseder U, Grove M, Hölzer A, Klos A, Köhl J, Bautsch W (September 1998). "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor". Journal of Immunology. 161 (5): 2089–93. PMID 9725198.
Davoust N, Jones J, Stahel PF, Ames RS, Barnum SR (May 1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells". Glia. 26 (3): 201–11. doi:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. PMID 10340761.
Settmacher B, Bock D, Saad H, Gärtner S, Rheinheimer C, Köhl J, Bautsch W, Klos A (June 1999). "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a". Journal of Immunology. 162 (12): 7409–16. PMID 10358194.
Feild JA, Foley JJ, Testa TT, Nuthulaganti P, Ellis C, Sarau HM, Ames RS (October 1999). "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15". FEBS Letters. 460 (1): 53–6. doi:10.1016/S0014-5793(99)01317-4. PMID 10571060. S2CID 86483726.
Petering H, Köhl J, Weyergraf A, Dulkys Y, Kimmig D, Smolarski R, Kapp A, Elsner J (April 2000). "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a". Journal of Immunology. 164 (7): 3783–9. doi:10.4049/jimmunol.164.7.3783. PMID 10725738.
Drouin SM, Kildsgaard J, Haviland J, Zabner J, Jia HP, McCray PB, Tack BF, Wetsel RA (February 2001). "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma". Journal of Immunology. 166 (3): 2025–32. doi:10.4049/jimmunol.166.3.2025. PMID 11160252.
Ames RS, Lee D, Foley JJ, Jurewicz AJ, Tornetta MA, Bautsch W, Settmacher B, Klos A, Erhard KF, Cousins RD, Sulpizio AC, Hieble JP, McCafferty G, Ward KW, Adams JL, Bondinell WE, Underwood DC, Osborn RR, Badger AM, Sarau HM (May 2001). "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models". Journal of Immunology. 166 (10): 6341–8. doi:10.4049/jimmunol.166.10.6341. PMID 11342658.
Kirchhoff K, Weinmann O, Zwirner J, Begemann G, Götze O, Kapp A, Werfel T (June 2001). "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin". Immunology. 103 (2): 210–7. doi:10.1046/j.1365-2567.2001.01197.x. PMC 1783227. PMID 11412308.
Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S, Glodek A, Honczarenko M, Spruce LA, Janowska-Wieczorek A, Lambris JD, Ratajczak MZ (May 2003). "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1". Blood. 101 (10): 3784–93. doi:10.1182/blood-2002-10-3233. PMID 12511407.

외부 링크

"Anaphylatoxin Receptors: C3a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
C3AR1+단백질+미국국립의학도서관 의학주제목(MeSH)
UCSC Genome Browser의 인간 C3AR1 게놈 위치 및 C3AR1 유전자 세부 정보 페이지.

인간 염색체 12번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000171860 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000040552 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8605247-5] Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.

[pmid15723703-6] Ali H, Panettieri RA (February 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research. 6: 19. doi:10.1186/1465-9921-6-19. PMC 551592. PMID 15723703.

[pmid=_23383423-7] Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.

[8] Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt.12405. PMC 3809075. PMID 24033923.

[9] Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.

[10] Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4): 747–58. doi:10.1002/cam4.241. PMC 4303144. PMID 24711204.

[11] Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP (2013). "Downsizing a human inflammatory protein to a small molecule with equal potency and functionality". Nature Communications. 4: 2802. doi:10.1038/ncomms3802. PMID 24257095.

[12] Reid RC, Yau MK, Singh R, Lim J, Fairlie DP (August 2014). "Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides". Journal of the American Chemical Society. 136 (34): 11914–7. doi:10.1021/ja506518t. PMID 25102224.

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C3a수용체

네임스페이스

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작용제 및 길항제

레퍼런스

추가 정보

외부 링크