릴RB4

릴RB4
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	3P2T
식별자
별칭	LILRB4, CD85K, ILT-3, ILT3, LIR-5, LIR5, 수용체 B4와 같은 백혈구 면역글로불린
외부 ID	OMIM: 604821 MGI: 102702 호몰로진: 86756 GeneCard: LILRB4
유전자 위치(인간)
쳇.	19번 염색체(인간)
끝	54,670,359 bp
유전자 위치(마우스)
쳇.	10번 염색체(쥐)
끝	51,362,799 bp
RNA 표현 패턴
	표현된 상단
	시신막; ; 흑인의 실체; ; 림프절; ; 맹장; ; 핏덩어리; ; 비뇨기 방광; ; 비장의; ; 흉선; ; 좌측 폐 상부엽;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	GO:0003823 항원 결합; GO:0001948 단백질 결합; 신호 수용체 활성;
셀룰러 컴포넌트	세포외 외성체; 플라즈마 막; 막으로 막다; 막의 적분 성분;
생물학적 과정	RNA 중합효소 II에 의한 이전-miRNA 전사의 음성 조절; 면역 체계 과정; 적응 면역 반응; 신호 전달; 골성 분화의 부정적 규제; 규제 T세포 분화의 양성 규제; T세포 수용체 신호 경로의 음성 조절; 핵에 대한 단백질 국산화 부정 규제;
	출처:아미고 / 퀵고
직교체
	11006
	14727
ENSG00000275730; ENSG00000186818; ENSG00000276042; ENSG00000278279; ENSG00000278555;
	n/a
	ENSMUSG00000112023
	Q8NHJ6
	Q61450
NM_001081438; NM_001278426; NM_001278427; NM_001278428; NM_001278429;
	NM_001278430; NM_006847; NM_001394933; NM_001394934; NM_001394935; NM_001394936; NM_001394937; NM_001394938; NM_001394939
	NM_001291892; NM_001291893; NM_008147
	NP_001265355; NP_001265356; NP_001265357; NP_001265358; NP_001265359
	NP_001278821; NP_001278822; NP_032173
	위키다타
인간 보기/편집	마우스 보기/편집

백혈구 면역글로불린과 같은 수용체 하위 가족 B 멤버 4는 인간에서 LILRB4 유전자에 의해 암호화된 단백질이다.^[5]^[6]^[7]

이 유전자는 백혈구 면역글로불린 유사 수용체(LIR) 계열의 구성원으로 염색체 부위 19q13.4의 유전자 군집 안에서 발견된다.인코딩된 단백질은 2개 또는 4개의 세포외 면역글로불린 영역, 투과성 영역, 2~4개의 세포질 면역수용체 타이로신 기반 억제 모티브(ITIMs)를 포함하는 LIR 수용체 하위 제품군 B 등급에 속한다.수용체는 단세포에 발현되며 면역반응의 자극을 억제하는 음성신호를 변환한다.수용체는 항원 포획과 발현에서도 기능할 수 있다.그것은 면역 반응의 초점을 맞추고 자동 주의 활동을 제한하는 데 도움을 주기 위해 염증 반응과 세포독성을 조절하는 것으로 생각된다.또한 LILRB4는 종양 면역 치료의 잠재적 목표가 될 것으로 제안되었다.종양과 관련된 대식세포에 대해 표현하고 종양의 면역 반응을 부정적으로 조절하는 것으로 나타났다.^[8]단세포 골수성 백혈병 세포에 대한 LILRB4의 표현은 침투를 지지하고 T세포 증식을 억제한다.이 유전자에 대해 서로 다른 ISO 양식을 인코딩하는 다중 대본 변형이 발견되었다.^[7]

상호작용

LILRB4는 PTPN6^[9] 및 INPP5D(선박-1)와 상호작용하는 것으로 나타났다.^[10]

참고 항목

참조

^ ^a ^b ^c ENSG00000186818, ENSG00000276042, ENSG00000278279, ENSG00000278555 GRCh38: Ensembl release 89: ENSG00000275730, ENSG00000186818, ENSG00000276042, ENSG00000278279, ENSG00000278555 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000112023 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
^ Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.
^ ^a ^b "Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4".
^ Sharma N, Atolagbe OT, Ge Z, Allison JP (July 2021). "LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy". The Journal of Experimental Medicine. 218 (7). doi:10.1084/jem.20201811. PMC 8117208. PMID 33974041.
^ Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. PMID 9973385.
^ Zurli V, Wimmer G, Cattaneo F, Candi V, Cencini E, Gozzetti A, et al. (November 2017). "Ectopic ILT3 controls BCR-dependent activation of Akt in B-cell chronic lymphocytic leukemia". Blood. 130 (18): 2006–2017. doi:10.1182/blood-2017-03-775858. PMID 28931525.

추가 읽기

Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. (October 2018). "LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration". Nature. 562 (7728): 605–609. doi:10.1038/s41586-018-0615-z. PMC 6296374. PMID 30333625.
John S, Chen H, Deng M, Gui X, Wu G, Chen W, Li Z, Zhang N, An Z, Zhang CC (October 2018). "A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML". Molecular Therapy. 26 (10): 2487–2495. doi:10.1016/j.ymthe.2018.08.001. PMC 6171100. PMID 30131301.
Gui X, Deng M, Song H, Chen Y, Xie J, Li Z, et al. (August 2019). "Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development". Cancer Immunology Research. 7 (8): 1244–1257. doi:10.1158/2326-6066.CIR-19-0036. PMC 6677629. PMID 31213474.
Suciu-Foca N, Cortesini R (July 2007). "Central role of ILT3 in the T suppressor cell cascade". Cellular Immunology. 248 (1): 59–67. doi:10.1016/j.cellimm.2007.01.013. PMID 17923119.
Arm JP, Nwankwo C, Austen KF (September 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". Journal of Immunology. 159 (5): 2342–9. PMID 9278324.
Kuroiwa A, Yamashita Y, Inui M, Yuasa T, Ono M, Nagabukuro A, et al. (January 1998). "Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene". The Journal of Biological Chemistry. 273 (2): 1070–4. doi:10.1074/jbc.273.2.1070. PMID 9422771.
Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–6. PMID 9548455.
Torkar M, Norgate Z, Colonna M, Trowsdale J, Wilson MJ (December 1998). "Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex". European Journal of Immunology. 28 (12): 3959–67. doi:10.1002/(SICI)1521-4141(199812)28:12<3959::AID-IMMU3959>3.0.CO;2-2. PMID 9862332.
Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. PMID 9973385.
Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, et al. (April 2000). "Plasticity in the organization and sequences of human KIR/ILT gene families". Proceedings of the National Academy of Sciences of the United States of America. 97 (9): 4778–83. Bibcode:2000PNAS...97.4778W. doi:10.1073/pnas.080588597. PMC 18309. PMID 10781084.
Heinzmann A, Blattmann S, Forster J, Kuehr J, Deichmann KA (June 2000). "Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy". European Journal of Immunogenetics. 27 (3): 121–7. doi:10.1046/j.1365-2370.2000.00214.x. PMID 10940079.
Liu WR, Kim J, Nwankwo C, Ashworth LK, Arm JP (July 2000). "Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4". Immunogenetics. 51 (8–9): 659–69. doi:10.1007/s002510000183. PMID 10941837. S2CID 23687483.
Young NT, Canavez F, Uhrberg M, Shum BP, Parham P (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.
Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, et al. (March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nature Immunology. 3 (3): 237–43. doi:10.1038/ni760. PMID 11875462. S2CID 35400503.
LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED (April 2005). "HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells". FASEB Journal. 19 (6): 662–4. doi:10.1096/fj.04-1617fje. PMID 15670976. S2CID 24608530.
Garner LI, Salim M, Mohammed F, Willcox BE (June 2006). "Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies". Protein Expression and Purification. 47 (2): 490–7. doi:10.1016/j.pep.2005.11.020. PMID 16406677.
Kim-Schulze S, Seki T, Vlad G, Scotto L, Fan J, Colombo PC, et al. (January 2006). "Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells". American Journal of Transplantation. 6 (1): 76–82. doi:10.1111/j.1600-6143.2005.01162.x. PMID 16433759. S2CID 7662795.
Kim-Schulze S, Scotto L, Vlad G, Piazza F, Lin H, Liu Z, et al. (March 2006). "Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells". Journal of Immunology. 176 (5): 2790–8. doi:10.4049/jimmunol.176.5.2790. PMID 16493035.
Vlad G, Liu Z, Zhang QY, Cortesini R, Suciu-Foca N (December 2006). "Immunosuppressive activity of recombinant ILT3". International Immunopharmacology. 6 (13–14): 1889–94. doi:10.1016/j.intimp.2006.07.017. PMID 17161342.

외부 링크

LILRB4+단백질,+인간, 미국 국립 의학 도서관의 의학 과목 제목(MSH)

이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

이 면역학 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

이 막 단백질 관련 기사는 뭉툭하다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] ENSG00000186818, ENSG00000276042, ENSG00000278279, ENSG00000278555 GRCh38: Ensembl release 89: ENSG00000275730, ENSG00000186818, ENSG00000276042, ENSG00000278279, ENSG00000278555 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000112023 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9151699-5] Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.

[pmid9079806-6] Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.

[entrez-7] "Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4".

[8] Sharma N, Atolagbe OT, Ge Z, Allison JP (July 2021). "LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy". The Journal of Experimental Medicine. 218 (7). doi:10.1084/jem.20201811. PMC 8117208. PMID 33974041.

[pmid9973385-9] Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (February 1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. PMID 9973385.

[pmid28931525-10] Zurli V, Wimmer G, Cattaneo F, Candi V, Cencini E, Gozzetti A, et al. (November 2017). "Ectopic ILT3 controls BCR-dependent activation of Akt in B-cell chronic lymphocytic leukemia". Blood. 130 (18): 2006–2017. doi:10.1182/blood-2017-03-775858. PMID 28931525.

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v t 단백질: 분화의 군집(인간 분화의 군집 목록 참조)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83년 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158(a) d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218(a) b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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