BRS-3 또는 BB로도 알려진 봄베신 수용체 하위 타입3 [5] 3 은 인간에서 BRS3 유전자 에 의해 인코딩되는 단백질 이다.[6] [7]
함수 포유류 봄베신 같은 펩타이드들은 위장관 뿐만 아니라 중추신경계 에도 널리 분포하고 있는데, 이들은 매끄러운 근육 수축, 외분비 및 내분비 과정, 신진대사, 행동 등을 조절한다. 그들은 세포 표면의 G 단백질 결합 수용체와 결합하여 그 효과를 이끌어낸다. 봄베신 유사 펩타이드 수용체에는 위트린 방출 펩타이드 수용체, 뉴로메딘 B 수용체 , 봄베신 유사 수용체-3(BRS3, 본조) 등이 있다.[7] [8]
BB는3 G단백질결합수용기 다.[6] BB는3 친화력이 낮은 알려진 자연발생 봄베신 관련 펩타이드와만 상호작용하므로 자연발생 고선량 리간드가 없으므로 고아 수용체 로 분류된다.[6] [9] [10]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000102239 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000031130 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Bombesin Receptors: BB3 " . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology.^ a b c Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells" . J. Biol. Chem . 268 (8): 5979–84. doi :10.1016/S0021-9258(18)53415-3 PMID 8383682 . ^ a b Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res . 762 (1–2): 165–72. doi :10.1016/S0006-8993(97)00380-6 . PMID 9262170 . S2CID 1012779 . ^ "Entrez Gene: BRS3 bombesin-like receptor 3" .^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors" . J. Biol. Chem . 272 (41): 26062–26071. doi :10.1074/jbc.272.41.26062 PMID 9325344 . ^ Jensen RT, Battey JF, Spindel ER, Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states" . Pharmacol. Rev . 60 (1): 1–42. doi :10.1124/pr.107.07108 . PMC 2517428 PMID 18055507 .
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