호모 사피엔스 종의 단백질 코드 유전자
히드록시카르본산수용체1 (HCA1 )은 이전에 G단백질결합수용체81 (GPR81 )로 알려진 단백질 로 HCAR1 [5] [6] HCA는1 다른 히드록시카르본산 수용체2 HCA 및 HCA 와3 마찬가지로 G 결합i/o G 단백질 결합 수용체(GPCR)[7] [8] HCA의1 주요 내인성 작용제 는 젖산 (및 그 결합염기 인 젖산)[7] [8]
젖산염 은 [9] [10] 지방세포 의 지방분해를 억제 하는 HCA를 활성화시킨다1 .
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000196917 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000049241 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: GPR81 G protein-coupled receptor 81" .^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene . 275 (1): 83–91. doi :10.1016/S0378-1119(01)00651-5 . PMID 11574155 . ^ a b Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (June 2011). "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)" . Pharmacological Reviews . 63 (2): 269–90. doi :10.1124/pr.110.003301 PMID 21454438 . ^ a b S Offermanns, SL Colletti, AP IJzerman, TW Lovenberg, G Semple, A Wise, MG Waters. "Hydroxycarboxylic acid receptors" . IUPHAR/BPS Guide to Pharmacology . International Union of Basic and Clinical Pharmacology. Retrieved 13 July 2018 . {{cite web }}: CS1 maint: 여러 이름: 작성자 목록(링크 ) ^ Liu C, Wu J, Zhu J, Kuei C, Yu J, Shelton J, Sutton SW, Li X, Yun SJ, Mirzadegan T, Mazur C, Kamme F, Lovenberg TW (January 2009). "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81" . The Journal of Biological Chemistry . 284 (5): 2811–22. doi :10.1074/jbc.M806409200 PMID 19047060 . ^ Cai TQ, Ren N, Jin L, Cheng K, Kash S, Chen R, Wright SD, Taggart AK, Waters MG (December 2008). "Role of GPR81 in lactate-mediated reduction of adipose lipolysis". Biochemical and Biophysical Research Communications . 377 (3): 987–91. doi :10.1016/j.bbrc.2008.10.088 . PMID 18952058 . 추가 정보 Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence" . FEBS Letters . 520 (1–3): 97–101. doi :10.1016/S0014-5793(02)02775-8 PMID 12044878 . S2CID 7116392 . Mao M, Biery MC, Kobayashi SV, Ward T, Schimmack G, Burchard J, Schelter JM, Dai H, He YD, Linsley PS (June 2004). "T lymphocyte activation gene identification by coregulated expression on DNA microarrays". Genomics . 83 (6): 989–99. doi :10.1016/j.ygeno.2003.12.019 . PMID 15177553 . Madaan A, Nadeau-Vallée M, Rivera JC, Obari D, Hou X, Sierra EM, Girard S, Olson DM, Chemtob S (September 2016). "Lactate produced during labor modulates uterine inflammation via GPR81 (HCA1)" . American Journal of Obstetrics and Gynecology . 216 (1): 60.e1–60.e17. doi :10.1016/j.ajog.2016.09.072 PMID 27615440 .
